Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation.

Chellappan, DK; Yee, NJ; Kaur Ambar Jeet Singh, BJ; Panneerselvam, J; Madheswaran, T; Chellian, J; Satija, S; Mehta, M; Gulati, M; Gupta, G; Dua, K

Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation.

Chellappan, DK Yee, NJ Kaur Ambar Jeet Singh, BJ Panneerselvam, J Madheswaran, T Chellian, J Satija, S

Mehta, M Gulati, M Gupta, G Dua, K

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Publisher:: Future Science
Publication Type:: Journal Article
Citation:: Therapeutic Delivery, 2019, 10, (5), pp. 281-293
Issue Date:: 2019-05-16

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Field	Value	Language
dc.contributor.author	Chellappan, DK
dc.contributor.author	Yee, NJ
dc.contributor.author	Kaur Ambar Jeet Singh, BJ
dc.contributor.author	Panneerselvam, J
dc.contributor.author	Madheswaran, T
dc.contributor.author	Chellian, J
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Mehta, M
dc.contributor.author	Gulati, M
dc.contributor.author	Gupta, G
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2020-05-19T03:38:00Z
dc.date.available	2020-05-19T03:38:00Z
dc.date.issued	2019-05-16
dc.identifier.citation	Therapeutic Delivery, 2019, 10, (5), pp. 281-293
dc.identifier.issn	2041-5990
dc.identifier.issn	2041-6008
dc.identifier.uri	http://hdl.handle.net/10453/140815
dc.description.abstract	Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	Future Science
dc.relation.ispartof	Therapeutic Delivery
dc.relation.isbasedon	10.4155/tde-2019-0019
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	0903 Biomedical Engineering, 1004 Medical Biotechnology, 1115 Pharmacology and Pharmaceutical Sciences
dc.title	Formulation and characterization of glibenclamide and quercetin-loaded chitosan nanogels targeting skin permeation.
dc.type	Journal Article
utslib.citation.volume	10
utslib.location.activity	England
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
utslib.for	0903 Biomedical Engineering
utslib.for	1004 Medical Biotechnology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2020-05-19T03:37:54Z
pubs.issue	5
pubs.publication-status	Published
pubs.volume	10
utslib.start-page	281
utslib.citation.issue	5

Abstract:

Aim: Our aim was to develop and characterize a nanogel formulation containing both glibenclamide and quercetin and to explore the permeation profile of this combination. Methods: Drug-loaded nanogel was prepared by ionic gelation. In addition, optimum encapsulation efficiencies of glibenclamide and quercetin were also obtained. The average nanoparticle size at optimum conditions was determined by Zetasizer. Results: The particle size of the nanogel was found to be 370.4 ± 4.78 nm with a polydispersity index of 0.528 ± 0.04, while the λ potential was positive in a range of 17.6 to 24.8 mV. The percentage cumulative drug release also showed favorable findings. Conclusion: The chitosan nanogel could be a potential alternative for delivering glibenclamide and quercetin through skin.

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http://hdl.handle.net/10453/140815