Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.

Altamish, M; Dahiya, R; Singh, AK; Mishra, A; Aljabali, AAA; Satija, S; Mehta, M; Dureja, H; Prasher, P; Negi, P; Kapoor, DN; Goyal, R; Tambuwala, MM; Chellappan, DK; Dua, K; Gupta, G

Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.

Altamish, M Dahiya, R Singh, AK Mishra, A Aljabali, AAA Satija, S

Mehta, M Dureja, H Prasher, P Negi, P Kapoor, DN Goyal, R Tambuwala, MM Chellappan, DK Dua, K

Gupta, G

Permalink

Publisher:: Begell House
Publication Type:: Journal Article
Citation:: Critical Reviews in Eukaryotic Gene Expression, 2020, 30, (3), pp. 245-252
Issue Date:: 2020-01

Closed Access

	Filename	Description	Size
	SerineThreonine Kinase_CRE_33451.pdf	Published version	347.64 kB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Altamish, M
dc.contributor.author	Dahiya, R
dc.contributor.author	Singh, AK
dc.contributor.author	Mishra, A
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Satija, S https://orcid.org/0000-0003-4702-6534
dc.contributor.author	Mehta, M
dc.contributor.author	Dureja, H
dc.contributor.author	Prasher, P
dc.contributor.author	Negi, P
dc.contributor.author	Kapoor, DN
dc.contributor.author	Goyal, R
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Gupta, G
dc.date.accessioned	2021-05-14T03:15:45Z
dc.date.available	2021-05-14T03:15:45Z
dc.date.issued	2020-01
dc.identifier.citation	Critical Reviews in Eukaryotic Gene Expression, 2020, 30, (3), pp. 245-252
dc.identifier.issn	1045-4403
dc.identifier.issn	2162-6502
dc.identifier.uri	http://hdl.handle.net/10453/148900
dc.description.abstract	Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but it remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumor growth in the cancers of PJS patients. This article focuses on the role of LKB1 or STK11 gene expression in PJS and related cancers.
dc.format	Print
dc.language	eng
dc.publisher	Begell House
dc.relation.ispartof	Critical Reviews in Eukaryotic Gene Expression
dc.relation.isbasedon	10.1615/critreveukaryotgeneexpr.2020033451
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0604 Genetics
dc.subject.classification	Biochemistry & Molecular Biology
dc.title	Role of the Serine/Threonine Kinase 11 (STK11) or Liver Kinase B1 (LKB1) Gene in Peutz-Jeghers Syndrome.
dc.type	Journal Article
utslib.citation.volume	30
utslib.location.activity	United States
utslib.for	0604 Genetics
utslib.for	0604 Genetics
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
pubs.consider-herdc	true
dc.date.updated	2021-05-14T03:15:43Z
pubs.issue	3
pubs.publication-status	Published
pubs.volume	30
utslib.citation.issue	3

Abstract:

Peutz-Jeghers syndrome (PJS) is a well-described inherited syndrome, characterized by the development of gastrointestinal polyps and characteristic mucocutaneous freckling. PJS is an autosomal prevailing disease, due to genetic mutation on chromosome 19p, manifested by restricted mucocutaneous melanosis in association with gastrointestinal (GI) polyposis. The gene for PJS has recently been shown to be a serine/threonine kinase, known as LKB1 or STK11, which maps to chromosome subband 19p13.3. This gene has a putative coding region of 1302 bp, divided into nine exons, and acts as a tumor suppressor in the hamartomatous polyps of PJS patients and in the other neoplasms that develop in PJS patients. It is probable that these neoplasms develop from hamartomas, but it remains possible that the LKB1 or STK11 locus plays a role in a different genetic pathway of tumor growth in the cancers of PJS patients. This article focuses on the role of LKB1 or STK11 gene expression in PJS and related cancers.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/148900