Synthesis and anticancer properties of ‘Azole’ based chemotherapeutics as emerging chemical moieties: A comprehensive review

Prasher, P; Sharma, M; Zacconi, F; Gupta, G; Aljabali, AAA; Mishra, V; Tambuwala, MM; Kapoor, DN; Negi, P; Pinto, TDJA; Singh, I; Chellappan, DK; Dua, K

Synthesis and anticancer properties of ‘Azole’ based chemotherapeutics as emerging chemical moieties: A comprehensive review

Prasher, P Sharma, M Zacconi, F Gupta, G Aljabali, AAA Mishra, V Tambuwala, MM Kapoor, DN Negi, P Pinto, TDJA Singh, I Chellappan, DK Dua, K

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Publisher:: Bentham Science Publishers Ltd.
Publication Type:: Journal Article
Citation:: Current Organic Chemistry, 2021, 25, (6), pp. 654-668
Issue Date:: 2021-01-01

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Field	Value	Language
dc.contributor.author	Prasher, P
dc.contributor.author	Sharma, M
dc.contributor.author	Zacconi, F
dc.contributor.author	Gupta, G
dc.contributor.author	Aljabali, AAA
dc.contributor.author	Mishra, V
dc.contributor.author	Tambuwala, MM
dc.contributor.author	Kapoor, DN
dc.contributor.author	Negi, P
dc.contributor.author	Pinto, TDJA
dc.contributor.author	Singh, I
dc.contributor.author	Chellappan, DK
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.date.accessioned	2022-05-30T01:07:07Z
dc.date.available	2022-05-30T01:07:07Z
dc.date.issued	2021-01-01
dc.identifier.citation	Current Organic Chemistry, 2021, 25, (6), pp. 654-668
dc.identifier.issn	1385-2728
dc.identifier.uri	http://hdl.handle.net/10453/157811
dc.description.abstract	Azole frameworks serve as privileged scaffolds in the contemporary drug design paradigm owing to their unique physicochemical profile that promotes the development of highly selective, physiological benevolent chemotherapeutics. Several azole nuclei function as bioisostere in medicinal chemistry and prompt the development of tailored therapeutics for targeting the desired biological entities. Besides, the azole scaffold forms an integral part in the advanced drug designing methodologies, such as target template in-situ drug synthesis, that assists in rapid identification of the hit molecules form a diverse pool of leads; and direct biomolecule-drug conjugation, along with bioorthogonal strategies that ensure localization, and superior target specificity of the directed therapeutic. Lastly, the structural diversity of azole framework and high yielding click synthetic meth-ods provide a comprehensive Structure-Activity Relationship analysis for design optimization of the potential drug molecules by fine-tuning the placement of different substituents critical for the activity. This review provides a comprehensive analysis of the synthesis and anticancer potential of azole based chemotherapeutics.
dc.language	en
dc.publisher	Bentham Science Publishers Ltd.
dc.relation.ispartof	Current Organic Chemistry
dc.relation.isbasedon	10.2174/1385272824999200820152501
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0305 Organic Chemistry
dc.subject.classification	Organic Chemistry
dc.title	Synthesis and anticancer properties of ‘Azole’ based chemotherapeutics as emerging chemical moieties: A comprehensive review
dc.type	Journal Article
utslib.citation.volume	25
utslib.for	0305 Organic Chemistry
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Faculty of Health/Graduate School of Health/GSH.Pharmacy
utslib.copyright.status	closed_access	*
dc.date.updated	2022-05-30T01:07:05Z
pubs.issue	6
pubs.publication-status	Published
pubs.volume	25
utslib.citation.issue	6

Abstract:

Azole frameworks serve as privileged scaffolds in the contemporary drug design paradigm owing to their unique physicochemical profile that promotes the development of highly selective, physiological benevolent chemotherapeutics. Several azole nuclei function as bioisostere in medicinal chemistry and prompt the development of tailored therapeutics for targeting the desired biological entities. Besides, the azole scaffold forms an integral part in the advanced drug designing methodologies, such as target template in-situ drug synthesis, that assists in rapid identification of the hit molecules form a diverse pool of leads; and direct biomolecule-drug conjugation, along with bioorthogonal strategies that ensure localization, and superior target specificity of the directed therapeutic. Lastly, the structural diversity of azole framework and high yielding click synthetic meth-ods provide a comprehensive Structure-Activity Relationship analysis for design optimization of the potential drug molecules by fine-tuning the placement of different substituents critical for the activity. This review provides a comprehensive analysis of the synthesis and anticancer potential of azole based chemotherapeutics.

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http://hdl.handle.net/10453/157811