A randomized, double-blinded, placebo-controlled trial of the effects of infusing local analgesia on post-operative pain during laparoscopic inguinal hernia repair.
- Publisher:
- SPRINGER
- Publication Type:
- Journal Article
- Citation:
- Surg Endosc, 2023, 37, (3), pp. 1970-1975
- Issue Date:
- 2023-03
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s00464-022-09697-7.pdf | Published version | 565.99 kB | Adobe PDF |
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Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author | Rade, M | |
dc.contributor.author | Jayaram, A | |
dc.contributor.author | Birkett, R | |
dc.contributor.author |
Ford, H |
|
dc.contributor.author | Birkett, D | |
dc.contributor.author | Nepomnayshy, D | |
dc.date.accessioned | 2023-10-12T00:58:49Z | |
dc.date.available | 2022-09-29 | |
dc.date.available | 2023-10-12T00:58:49Z | |
dc.date.issued | 2023-03 | |
dc.identifier.citation | Surg Endosc, 2023, 37, (3), pp. 1970-1975 | |
dc.identifier.issn | 0930-2794 | |
dc.identifier.issn | 1432-2218 | |
dc.identifier.uri | http://hdl.handle.net/10453/172657 | |
dc.description.abstract | PURPOSE: While it is widely accepted that laparoscopic total extraperitoneal (TEP) inguinal herniorrhaphy has decreased post-operative pain, there are conflicting data as to whether instillation of local anesthetic into the preperitoneal space improves post-operative pain in these patients. We designed a prospective study to evaluate this. Secondary outcomes include time spent in the PACU, need for narcotic pain medication, and total amount of narcotics required postoperatively. METHODS: Prospective, randomized, double-blind, placebo-controlled study which enrolled 70 patients with unilateral non-recurrent inguinal hernia from 09/2013 to 03/2019 and included immediate and 2-week post-operative follow-up. All patients received unilateral laparoscopic TEP inguinal hernia repair with control patients receiving 10 ml of 0.9% saline instilled into preperitoneal space while treatment group received 10-ml 0.5% bupivacaine without epinephrine. RESULTS: A total of 70 patients [67 (96%) men and 3 women; mean age (SD), 57 years (13.8)] were enrolled, 35 randomized into each group. Demographics between the two groups were similar. No differences were found in post-operative pain between the control and test groups at 1 h [mean (SD) of 3.15(2.5) vs 3.21(2.9); P = 0.92], 2 h [3.39 (1.55) vs 2.74 (1.85) P = 0.18], or 1 day [4.79 (2.19) vs 4.39 (2.37); P = 0.13] postoperatively. Likewise, no significant differences were observed in usage of narcotic pain medication postoperatively, as 17 control patients (50%) and 16 (46%) study patients required narcotics within 2 h of surgery (P = 0.72). CONCLUSION: Instilling local anesthetic into the preperitoneal space during laparoscopic TEP inguinal hernia repair did not result in statistically significant difference in post-operative pain (Rade et al. in NESS Annual Meeting, 2021). Trial registry ClinicalTrials.gov Identifier: NCT02055053. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.publisher | SPRINGER | |
dc.relation.ispartof | Surg Endosc | |
dc.relation.isbasedon | 10.1007/s00464-022-09697-7 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | 1103 Clinical Sciences | |
dc.subject.classification | Surgery | |
dc.subject.classification | 3202 Clinical sciences | |
dc.subject.mesh | Male | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Female | |
dc.subject.mesh | Anesthetics, Local | |
dc.subject.mesh | Hernia, Inguinal | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Pain, Postoperative | |
dc.subject.mesh | Laparoscopy | |
dc.subject.mesh | Narcotics | |
dc.subject.mesh | Analgesia | |
dc.subject.mesh | Herniorrhaphy | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Hernia, Inguinal | |
dc.subject.mesh | Pain, Postoperative | |
dc.subject.mesh | Anesthetics, Local | |
dc.subject.mesh | Narcotics | |
dc.subject.mesh | Laparoscopy | |
dc.subject.mesh | Analgesia | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Female | |
dc.subject.mesh | Male | |
dc.subject.mesh | Herniorrhaphy | |
dc.subject.mesh | Male | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Female | |
dc.subject.mesh | Anesthetics, Local | |
dc.subject.mesh | Hernia, Inguinal | |
dc.subject.mesh | Prospective Studies | |
dc.subject.mesh | Pain, Postoperative | |
dc.subject.mesh | Laparoscopy | |
dc.subject.mesh | Narcotics | |
dc.subject.mesh | Analgesia | |
dc.subject.mesh | Herniorrhaphy | |
dc.title | A randomized, double-blinded, placebo-controlled trial of the effects of infusing local analgesia on post-operative pain during laparoscopic inguinal hernia repair. | |
dc.type | Journal Article | |
utslib.citation.volume | 37 | |
utslib.location.activity | Germany | |
utslib.for | 1103 Clinical Sciences | |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Arts and Social Sciences | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Arts and Social Sciences/Digital and Social Media | |
utslib.copyright.status | closed_access | * |
dc.date.updated | 2023-10-12T00:58:47Z | |
pubs.issue | 3 | |
pubs.publication-status | Published | |
pubs.volume | 37 | |
utslib.citation.issue | 3 |
Abstract:
PURPOSE: While it is widely accepted that laparoscopic total extraperitoneal (TEP) inguinal herniorrhaphy has decreased post-operative pain, there are conflicting data as to whether instillation of local anesthetic into the preperitoneal space improves post-operative pain in these patients. We designed a prospective study to evaluate this. Secondary outcomes include time spent in the PACU, need for narcotic pain medication, and total amount of narcotics required postoperatively. METHODS: Prospective, randomized, double-blind, placebo-controlled study which enrolled 70 patients with unilateral non-recurrent inguinal hernia from 09/2013 to 03/2019 and included immediate and 2-week post-operative follow-up. All patients received unilateral laparoscopic TEP inguinal hernia repair with control patients receiving 10 ml of 0.9% saline instilled into preperitoneal space while treatment group received 10-ml 0.5% bupivacaine without epinephrine. RESULTS: A total of 70 patients [67 (96%) men and 3 women; mean age (SD), 57 years (13.8)] were enrolled, 35 randomized into each group. Demographics between the two groups were similar. No differences were found in post-operative pain between the control and test groups at 1 h [mean (SD) of 3.15(2.5) vs 3.21(2.9); P = 0.92], 2 h [3.39 (1.55) vs 2.74 (1.85) P = 0.18], or 1 day [4.79 (2.19) vs 4.39 (2.37); P = 0.13] postoperatively. Likewise, no significant differences were observed in usage of narcotic pain medication postoperatively, as 17 control patients (50%) and 16 (46%) study patients required narcotics within 2 h of surgery (P = 0.72). CONCLUSION: Instilling local anesthetic into the preperitoneal space during laparoscopic TEP inguinal hernia repair did not result in statistically significant difference in post-operative pain (Rade et al. in NESS Annual Meeting, 2021). Trial registry ClinicalTrials.gov Identifier: NCT02055053.
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