Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases.

Solanki, N; Gupta, G; Chellappan, DK; Singh, SK; Gulati, M; Paudel, KR; Hansbro, PM; Dua, K; Bhan, S; Saini, M; Dureja, H

Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases.

Solanki, N Gupta, G Chellappan, DK Singh, SK Gulati, M Paudel, KR Hansbro, PM Dua, K

Bhan, S Saini, M Dureja, H

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Publisher:: BENTHAM SCIENCE PUBL LTD
Publication Type:: Journal Article
Citation:: Endocr Metab Immune Disord Drug Targets, 2024, 24, (1), pp. 116-129
Issue Date:: 2024

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Field	Value	Language
dc.contributor.author	Solanki, N
dc.contributor.author	Gupta, G
dc.contributor.author	Chellappan, DK
dc.contributor.author	Singh, SK
dc.contributor.author	Gulati, M
dc.contributor.author	Paudel, KR
dc.contributor.author	Hansbro, PM
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159
dc.contributor.author	Bhan, S
dc.contributor.author	Saini, M
dc.contributor.author	Dureja, H
dc.date.accessioned	2024-02-26T05:34:58Z
dc.date.available	2023-03-22
dc.date.available	2024-02-26T05:34:58Z
dc.date.issued	2024
dc.identifier.citation	Endocr Metab Immune Disord Drug Targets, 2024, 24, (1), pp. 116-129
dc.identifier.issn	1871-5303
dc.identifier.issn	2212-3873
dc.identifier.uri	http://hdl.handle.net/10453/175893
dc.description.abstract	BACKGROUND: In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases. OBJECTIVE: Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species. METHODS: Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases. RESULT: These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects. CONCLUSION: Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflammation. The review further explores the therapeutic potential of boswellic acids in.
dc.format	Print
dc.language	eng
dc.publisher	BENTHAM SCIENCE PUBL LTD
dc.relation.ispartof	Endocr Metab Immune Disord Drug Targets
dc.relation.isbasedon	10.2174/1871530323666230512154634
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	Immunology
dc.subject.classification	3202 Clinical sciences
dc.subject.classification	3204 Immunology
dc.subject.mesh	Humans
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Inflammation
dc.subject.mesh	Immunologic Factors
dc.subject.mesh	Immune System
dc.subject.mesh	Immune System
dc.subject.mesh	Humans
dc.subject.mesh	Inflammation
dc.subject.mesh	Anti-Inflammatory Agents
dc.subject.mesh	Plant Extracts
dc.subject.mesh	Immunologic Factors
dc.title	Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases.
dc.type	Journal Article
utslib.citation.volume	24
utslib.location.activity	United Arab Emirates
utslib.for	1107 Immunology
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Science
pubs.organisational-group	University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	University of Technology Sydney/Faculty of Health/Public Health
pubs.organisational-group	University of Technology Sydney/Strength - CFI - Centre for Inflammation
utslib.copyright.status	closed_access	*
dc.date.updated	2024-02-26T05:34:56Z
pubs.issue	1
pubs.publication-status	Published
pubs.volume	24
utslib.citation.issue	1

Abstract:

BACKGROUND: In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases. OBJECTIVE: Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species. METHODS: Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases. RESULT: These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects. CONCLUSION: Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflammation. The review further explores the therapeutic potential of boswellic acids in.

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http://hdl.handle.net/10453/175893