%PDF-1.3
%
7 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
4 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
1 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
8 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
6 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
9 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
5 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
3 0 obj
<>>>/BBox[0 0 612 792]/Length 53>>stream
xs
w3T0WI2P0T5T R
Ɩf
!\!Y\ !p
o
endstream
endobj
11 0 obj
<>stream
2019-02-14T02:51:04+05:30
Arbortext Advanced Print Publisher 9.0.114/W
2019-07-02T18:55:59-07:00
Acrobat Distiller 8.1.0 (Windows); modified using iText 4.2.0 by 1T3XT
application/pdf
ACM-2018-0311-ver9-Ryan_5P 249..256
uuid:4c3a8c80-47ab-48d0-9783-ad986e237e4b
uuid:60e6e3f8-1a5f-4d73-ba35-1fcdd351851e
endstream
endobj
12 0 obj
<>stream
x+ |
endstream
endobj
13 0 obj
<>stream
xS**T0T0 Bi yS&
endstream
endobj
14 0 obj
<>stream
x+ |
endstream
endobj
15 0 obj
<>stream
xS**T0T0 Bi y\'
endstream
endobj
16 0 obj
<>stream
x+ |
endstream
endobj
17 0 obj
<>stream
xS**T0T0 Bi yw*
endstream
endobj
18 0 obj
<>stream
x+ |
endstream
endobj
19 0 obj
<>stream
xS**T0T0 Bi y8#
endstream
endobj
20 0 obj
<>stream
x+ |
endstream
endobj
21 0 obj
<>stream
xS**T0T0 Bi ye(
endstream
endobj
22 0 obj
<>stream
x+ |
endstream
endobj
23 0 obj
<>stream
xS**T0T0 Bi yJ%
endstream
endobj
24 0 obj
<>stream
x+ |
endstream
endobj
25 0 obj
<>stream
xS**T0T0 Bi yA$
endstream
endobj
26 0 obj
<>stream
x+ |
endstream
endobj
27 0 obj
<>stream
xS**T0T0 Bi yn)
endstream
endobj
29 0 obj
<>stream
/GS1 gs
BT
/F3 1 Tf
8.9663 0 0 8.9663 62.022 725.7825 Tm
0 0 0 rg
0 Tc
0 Tw
(Introduction)Tj
/F12 1 Tf
26.1167 0 0 26.1167 61.0582 693.014 Tm
(U)Tj
/F13 1 Tf
9.843 0 0 9.843 80.7307 703.8423 Tm
[(se)-462.8(of)-464(dietary)-462.4(supplements)]TJ
/F5 1 Tf
12.7405 0 TD
[(in)-463.1(the)-459.6(United)-469.7(States)-463.9(is)]TJ
-12.7405 -1.1116 TD
[(widespread,)-249.1(with)-241.7(more)-242.9(than)-241.8(166)-245.2(million)-239.8(estimated)-245.2(users)]TJ
-1.9007 -1.1116 TD
.0121 Tc
[(an)5.2(d)-294.3(a)-1.7(n)-288.5(e)-1.7(st)5.1(imat)5.1(ed)-294.3(8)5.2(5)-.5(,0)5.2(00)-294.3(p)5.2(rod)5.2(ucts)-294.1(avail)5.1(a)-1.7(bl)5.1(e.)]TJ
7.3823 0 0 6.5614 241.1149 686.3242 Tm
.0128 Tc
(1,2)Tj
9.843 0 0 9.843 253.5306 681.9589 Tm
.0131 Tc
[(Ad)6.2(ult)6.1(s)-293.1(wi)6.1(th)]TJ
-19.4563 -1.1174 TD
.0117 Tc
[(card)4.8(io)4.8(vas)5(c)-2.1(u)4.8(l)-1(ar)-317.7(di)4.7(sease)-318.9(h)4.8(av)4.8(e)-318.9(a)-318.9(p)-.9(art)4.7(i)-1(cularl)4.7(y)-317.7(h)-.9(i)4.7(g)-.9(h)-317.7(p)4.8(rev)4.8(a)-2.1(l)4.7(e)-2.1(n)4.8(c)-2.1(e)]TJ
0 -1.1116 TD
.011 Tc
[(of)-410.5(use.)]TJ
7.3823 0 0 6.5614 90.4819 664.384 Tm
.0167 Tc
(3,4)Tj
9.843 0 0 9.843 104.1449 660.0187 Tm
.012 Tc
[(An)-415.3(an)5.1(al)5(ysi)5(s)-415.1(of)-409.5(th)5.1(e)-416.5(1)-.6(9)5.1(9)-.6(9)5.1(20)5.1(02)-409.6(Natio)5.1(nal)-415.4(H)-1.5(eal)5(t)-.7(h)]TJ
-4.2795 -1.1116 TD
.2259 Tc
[(a)212.1(n)219(dN)212.4(u)219(t)213.2(r)213.3(i)218.9(t)213.2(i)218.9(o)213.3(n).2(E)217.9(x)213.3(a)217.9(m)212.1(i)218.9(n)213.3(a)212.1(t)218.9(i)213.2(o)219(nS)213.4(u)219(r)213.3(v)213.3(e)217.9(y\()213.3(N)218.2(H)212.4(A)212.4(N)218.2(E)212.1(S)219.2(\)d)213.3(a)217.9(t)213.2(as)213.5(h)219(o)213.3(w)218.2(e)212.1(d)]TJ
0 -1.1174 TD
.0123 Tc
[(th)5.4(at)-472.7(64)5.4(%)-479.4(o)5.4(f)-472.6(r)-.3(es)5.6(po)5.4(ndent)5.3(s)-478.2(w)4.6(it)5.3(h)-478.4(h)5.4(yp)5.4(ert)5.3(e)-1.5(n)5.4(s)-.1(i)5.3(o)-.3(n)-472.6(t)-.4(o)5.4(o)-.3(k)-472.6(d)-.3(ietary)]TJ
0 -1.1116 TD
.0118 Tc
[(su)4.9(pp)4.9(lements)5.1(.)]TJ
7.3823 0 0 6.5614 114.9732 631.5022 Tm
0 Tc
(5)Tj
9.843 0 0 9.843 72 616.1951 Tm
[(Th)19.6(er)19.7(e)-584(i)0(s)-578.1(a)-584(co)13.9(m)15(m)0(o)19.6(n)-588.6(mi)19.5(sp)21(er)19.7(ce)18.5(pt)15(io)20.7(n)-582.8(a)0(m)18.5(o)0(n)20.8(g)-588.6(he)19.7(al)19.6(th)-578.3(ca)18.5(re)]TJ
-1.0137 -1.1116 TD
[(pr)20.9(of)15.1(es)19.9(si)20.9(on)20.8(al)19.5(s)-715.1(t)0(h)20.7(a)0(t)-700.4(d)0(i)20.7(e)0(t)19.5(a)0(r)19.7(y)-715.3(su)21(pp)20.8(le)19.6(me)18.4(nt)20.7(s)-715.1(a)0(r)19.7(e)-710.7(un)20.8(re)19.7(gu)20.8(la)19.6(te)13.8(d.)]TJ
7.3823 0 0 6.5614 297.4109 609.6188 Tm
(1)Tj
9.843 0 0 9.843 62.022 594.2549 Tm
[(Ho)20(we)18.8(ve)13.9(r,)-442.2(di)20.7(et)19.5(ar)19.7(y)-450.4(s)0(u)15.3(p)0(p)20.8(l)0(e)19.5(m)0(e)18.4(n)0(t)20.7(s)]TJ
/F6 1 Tf
12.8499 0 TD
[(ar)21(e)]TJ
/F5 1 Tf
1.7625 0 TD
[(re)14(gu)20.8(la)19.6(te)19.6(d)-450.4(i)0(n)-445.8(t)0(h)20.7(e)-451.5(Un)14.2(it)20.6(ed)]TJ
-14.6124 -1.1116 TD
[(St)20.9(at)19.5(es)-348.7(as)-343(a)-353.6(s)0(p)21(e)0(c)18.5(i)0(a)19.6(l)-352.6(ca)18.5(te)13.8(go)20.8(ry)-342(of)-342(fo)20.9(od)15.1(s)-352.2(b)0(y)-342(t)0(h)20.7(e)-353.6(Fo)21(od)-342(an)19.7(d)-352.4(D)0(r)14.2(u)0(g)]TJ
T*
[(Ad)20(mi)19.5(ni)20.7(st)15.1(ra)19.7(ti)20.6(on)-324.7(\(F)21(DA)19.1(\))-335.1(u)0(n)20.8(d)0(e)19.7(r)-335.1(th)20.7(e)-336.3(D)0(i)19.8(e)0(t)19.5(a)0(r)19.7(y)-335.2(Su)21(pp)15.1(le)19.5(me)18.4(nt)-319.1(He)13(al)19.5(th)]TJ
0 -1.1174 TD
[(an)19.7(d)-502.2(E)0(d)19.6(u)0(c)13.9(a)0(t)19.5(i)0(o)20.7(n)-502.2(Ac)18.8(t)-502.3(\()0(D)14.2(H)0(S)20.1(E)0(A)18.8(\))0(.)]TJ
7.3823 0 0 6.5614 185.2724 565.7952 Tm
-.0162 Tc
[(1,)-16.2(2)]TJ
9.843 0 0 9.843 199.2755 561.3731 Tm
0 Tc
[(Re)18.6(gu)20.8(la)19.6(to)20.7(ry)-497.5(ag)19.7(en)19.7(ci)19.6(es)-492.7(al)13.8(so)]TJ
-13.9442 -1.1116 TD
[(ex)19.7(is)15.1(t)-312.3(i)0(n)-307.6(C)0(a)18.6(n)0(a)13.9(d)0(a)19.7(,)-314.4(Eu)19.6(ro)20.9(pe)13.9(,)-314.4(C)0(h)19.8(i)0(n)20.7(a)0(,)-311(I)0(n)20.9(d)0(i)20.7(a)0(,)-311(a)0(n)19.7(d)-317.9(Au)20(st)20.9(ra)19.7(li)14.8(a.)]TJ
7.3823 0 0 6.5614 271.1621 554.7967 Tm
(2)Tj
9.843 0 0 9.843 278.0219 550.4313 Tm
[(In)-307.4(th)20.7(e)]TJ
-21.9445 -1.1116 TD
[(Un)20(it)20.6(ed)-360.5(St)20.9(at)19.5(es)14.1(,)-366.3(d)0(i)20.7(e)0(t)19.5(a)0(r)19.7(y)-369.7(su)21(pp)15.1(le)19.6(me)18.4(nt)-353.7(ma)18.4(nu)15.1(fa)19.7(ct)19.5(ur)20.9(er)19.7(s)-369.5(a)0(r)19.7(e)-370.9(no)20.8(t)-369.8(r)0(e)19.7(-)]TJ
0 -1.1174 TD
[(qu)20.8(ir)15(ed)-406.5(to)-405.5(co)19.7(nd)20.8(uc)19.7(t)-421.7(p)0(r)20.9(o)0(s)21(p)0(e)19.7(c)0(t)19.5(i)0(v)15(e)-417(sa)19.9(fe)19.7(ty)-405.5(st)15.1(ud)20.8(ie)19.6(s,)-407.5(al)19.5(th)20.7(ou)20.8(gh)-411.1(th)20.7(ey)]TJ
0 -1.1116 TD
[(ar)19.7(e)-353.6(p)0(r)20.9(o)0(h)20.8(i)0(b)20.7(i)0(t)14.8(e)0(d)-337.4(f)0(r)20.9(o)0(m)-343.2(m)0(a)18.4(r)0(k)20.9(e)0(t)19.5(i)0(n)20.7(g)-352.4(pr)20.9(od)20.8(uc)19.7(ts)-342(or)-342(us)21(in)20.7(g)-352.4(i)0(n)20.7(g)0(r)20.9(e)0(d)19.7(i)0(e)19.6(n)0(t)14.9(s)]TJ
T*
[(kn)20.8(ow)20(n)-352.4(t)0(o)-336.4(b)0(e)-337.4(u)0(n)20.8(s)0(a)19.9(f)0(e)14(.)]TJ
7.3823 0 0 6.5614 142.9795 510.9731 Tm
(2)Tj
9.843 0 0 9.843 150.1228 506.6077 Tm
[(Ad)20(ve)19.7(rs)21.1(e)-347.8(e)0(v)13.9(e)0(n)19.7(t)0(s)-336.2(\()0(A)20(E)0(s)19.8(\))-352.4(oc)19.7(cu)19.7(r)-346.6(w)0(i)19.8(t)0(h)-336.4(d)0(i)14.9(e)0(-)]TJ
-8.9506 -1.1116 TD
[(ta)19.5(ry)-422.6(su)21(pp)20.8(le)19.5(me)18.4(nt)20.7(s,)-419(bu)20.8(t)-433.2(r)0(e)19.7(c)0(e)18.5(n)0(t)-417(e)0(s)19.9(t)0(i)14.8(m)0(a)18.4(t)0(e)19.6(s)-427.1(in)20.7(di)20.7(ca)12.8(te)-418.2(a)-428.5(r)0(e)19.7(l)0(a)19.6(t)0(i)14.8(v)0(e)19.7(l)0(y)]TJ
0 -1.1174 TD
[(lo)20.7(w)-353.3(i)0(n)20.7(c)0(i)19.5(d)0(e)19.7(n)0(c)19.7(e)0(,)-339.8(d)0(e)19.7(s)0(p)15.3(i)0(t)20.6(e)-347.8(fr)20.9(eq)13.9(ue)19.7(nt)20.7(ly)-336.4(vo)20.8(ic)13.8(ed)-337.4(co)19.7(nc)19.7(er)19.7(ns)-341.8(re)19.7(ga)19.7(rd)15.1(in)20.7(g)]TJ
0 -1.1116 TD
[(di)20.7(et)19.5(ar)14(y)-260.3(s)0(u)15.3(p)0(p)20.8(l)0(e)19.6(m)0(e)18.4(n)0(t)-255.8(s)0(a)19.9(f)0(e)19.7(t)0(y)15(.)]TJ
7.3823 0 0 6.5614 164.1259 478.0912 Tm
[(1,)20.4(2)]TJ
9.843 0 0 9.843 175.8047 473.7259 Tm
[(No)20(ta)19.6(bl)14.9(y,)-252.2(le)19.6(ss)-255.2(th)15(an)-251(on)15.1(e)-261.4(d)0(e)13.9(a)0(t)19.5(h)-266(pe)19.7(r)]TJ
-11.5597 -1.1116 TD
[(ye)19.7(ar)-366.2(ha)19.7(s)-369.5(b)0(e)19.7(e)0(n)-366.2(a)0(t)19.5(t)0(r)20.7(i)0(b)20.7(u)0(t)15(e)0(d)-360.5(t)0(o)-359.4(u)0(s)15.3(e)-370.9(of)-359.3(di)14.9(et)19.5(ar)19.7(y)-369.7(s)0(u)15.3(p)0(p)20.8(l)0(e)19.6(m)0(e)18.4(n)0(t)20.7(s)-369.5(ov)15.1(er)]TJ
0 -1.1174 TD
[(th)20.7(e)-417(l)0(a)19.6(s)0(t)-399.6(1)0(5)-405.4(y)0(e)19.7(a)0(r)19.7(s)0(,)-401.8(c)0(o)13.9(m)15(pa)13.9(re)19.7(d)-410(w)0(i)19.8(t)0(h)-405.5(m)0(o)19.6(r)0(e)-400.7(t)0(h)15(a)0(n)-400.8(2)0(5)20.8(,)0(0)18.5(0)0(0)-399.6(a)0(n)13.9(n)0(u)20.8(a)0(l)]TJ
0 -1.1116 TD
[(de)19.7(at)19.5(hs)-330.3(in)-330.6(th)20.7(e)-342.1(U)0(n)20(i)0(t)20.6(e)0(d)-331.7(S)0(t)20.9(a)0(t)19.5(e)0(s)-331.5(a)0(t)19.5(t)0(r)20.7(i)0(b)20.7(u)0(t)15(e)0(d)-325.9(t)0(o)-330.6(F)0(D)20.1(A)0(-)20(a)0(p)19.7(p)0(r)15.1(o)0(v)20.8(e)0(d)-325.9(p)0(r)15.1(e)0(-)]TJ
T*
[(sc)19.9(ri)15(pt)20.7(io)20.7(n)-323.6(d)0(r)20.9(u)0(g)20.8(s)0(.)]TJ
7.3823 0 0 6.5614 122.6834 434.2676 Tm
(1)Tj
9.843 0 0 9.843 72 418.9038 Tm
[(However,)-418.4(the)-413.5(limited)-413.8(availability)-420.7(of)-411.1(formal)-418(research)-416.4(on)]TJ
-1.0137 -1.1116 TD
[(dietary)-453.8(supplements)-459(creates)-455.8(a)-451.5(barrier)-459.3(to)-451.6(more)-450.3(widespread)]TJ
T*
[(clinical)-467.8(use.)-462.7(This)-460.5(is)-462.9(particularly)-466.4(relevant)-461.8(for)-464(naturopathic)]TJ
0 -1.1174 TD
[(physicians)-520.1(and)-517.1(other)-519.4(complementary)-522.8(medicine)-520.6(providers,)]TJ
0 -1.1116 TD
.0122 Tc
[(wh)5.3(o)-334.5(f)-.4(r)5.4(e)-1.6(qu)5.3(en)5.3(tl)5.2(y)-334.5(d)-.4(i)5.2(s)-.2(cu)5.3(ss)-334.3(th)5.3(e)-335.6(s)-.2(afety,)-331.1(qu)5.3(al)5.2(ity)5.3(,)-336.8(a)4.2(nd)-334.5(efcacy)-334.5(o)-.4(f)]TJ
T*
0 Tc
[(di)20.7(et)19.5(ar)14(y)-369.7(s)0(u)21(p)0(p)20.8(l)0(e)19.6(m)0(e)18.4(n)0(t)20.7(s)-375.3(du)20.8(ri)20.7(ng)-359.3(cl)19.5(in)15(ic)19.6(al)-360.6(en)19.7(co)19.7(un)20.8(te)19.6(rs)15.3(.)]TJ
7.3823 0 0 6.5614 249.7322 368.5038 Tm
[(6,)20.4(7)]TJ
9.843 0 0 9.843 262.4314 364.1385 Tm
.3706 Tc
[(Al)370.6(a)384.4(c)370.6(k)10.1(o)370.6(f)]TJ
-20.3606 -1.1116 TD
0 Tc
[(sa)19.9(fe)14(ty)20.7(-o)20.9(ri)20.7(en)19.7(te)19.6(d)-444.6(r)0(e)19.7(s)0(e)14.1(a)0(r)19.7(c)0(h)-429.6(o)0(n)-434.2(t)0(h)20.7(e)-445.8(te)19.6(ns)-434(of)-434.1(th)20.7(ou)20.8(sa)14.1(nd)20.8(s)-438.6(o)0(f)-434.1(a)0(v)19.7(a)0(i)13.8(l)0(-)]TJ
0 -1.1174 TD
[(ab)19.7(le)-228.1(di)14.9(et)19.5(ar)19.7(y)-237.2(s)0(u)21(p)0(p)20.8(l)0(e)13.8(m)0(e)18.4(n)0(t)20.7(s)-237(ge)19.7(ne)19.7(ra)19.7(te)13.8(s)-237(b)0(o)20.8(t)0(h)-227(c)0(l)19.5(i)0(n)20.7(i)0(c)13.8(a)0(l)-228.1(a)0(n)19.7(d)-237.2(sc)19.9(ie)19.6(nt)14.9(i)20.9(c)]TJ
0 -1.1116 TD
[(li)20.6(mi)19.5(ta)19.6(ti)14.8(on)20.8(s,)-430.6(as)-429.4(po)15.1(te)19.6(nt)20.7(ia)19.6(ll)20.6(y)-444.6(s)0(a)19.9(f)0(e)-429.5(a)0(n)19.7(d)-444.6(ef)19.7(c)19.8(ac)18.5(io)20.7(us)-434(su)21(pp)20.8(le)13.8(m)15(e)0(n)13.9(t)0(s)]TJ
T*
[(ma)18.4(y)-340.9(n)0(e)19.7(v)0(e)19.7(r)-346.6(be)-331.7(id)20.7(en)19.7(ti)20.6(e)19.8(d)-340.9(o)0(r)-336.2(d)0(e)19.7(s)0(c)19.9(r)0(i)20.7(b)0(e)19.7(d)-340.9(in)-336.4(pe)19.7(er)19.7(-r)20.9(ev)19.7(ie)19.6(we)13(d)-340.9(m)0(e)18.4(d)0(-)]TJ
0 -1.1174 TD
[(ic)19.5(al)-268.4(li)20.6(te)13.8(ra)19.7(tu)20.7(re)19.7(.)]TJ
7.3823 0 0 6.5614 115.9937 313.6818 Tm
(2)Tj
9.843 0 0 9.843 122.4 309.3164 Tm
[(Co)19.8(ns)15.3(eq)19.7(ue)19.7(nt)20.7(ly)20.7(,)-279.9(t)0(h)20.7(e)0(s)19.9(e)-278.7(li)20.6(mi)19.5(ta)19.6(ti)14.8(on)20.8(s)-277.4(a)0(l)19.6(s)0(o)-266.9(r)0(e)19.7(p)0(r)20.9(e)0(s)14.1(e)0(n)19.7(t)]TJ
-6.1341 -1.1116 TD
[(op)20.8(po)20.8(rt)15(un)20.8(it)20.6(ie)19.6(s)-404.1(t)0(o)-394(a)0(p)19.7(p)0(l)20.7(y)-404.3(in)20.7(no)20.8(va)19.7(ti)14.8(ve)-389.3(ea)18.5(rl)15(y-)20.9(ph)20.8(as)19.9(e)-405.4(s)0(t)20.9(u)0(d)20.8(y)-404.3(de)19.7(si)15.1(gn)20.8(s)]TJ
T*
[(to)-330.6(as)19.9(se)14.1(ss)-330.1(sa)19.9(fe)19.7(ty)-336.4(an)19.7(d)-340.9(a)0(l)19.5(s)0(o)-330.3(i)0(d)20.7(e)0(n)19.7(t)0(i)14.8(f)0(y)-330.5(p)0(o)20.8(t)0(e)19.6(n)0(t)20.7(i)0(a)19.6(l)0(l)14.8(y)-340.9(ef)19.7(c)19.8(ac)18.5(io)20.7(us)-330.3(di)14.9(e-)]TJ
0 -1.1174 TD
[(ta)19.5(ry)-313.2(su)15.3(pp)20.8(le)19.5(me)18.4(nt)20.7(s.)]TJ
7.3823 0 0 6.5614 130.9039 280.8566 Tm
-.0183 Tc
[(2,)-18.3(8,)-18.3(9)]TJ
9.843 0 0 9.843 72 265.4929 Tm
0 Tc
[(The)-656.5(authors)-659.6(previously)-663.1(reported)-656.3(on)-658.8(the)-661.2(naturopathic)]TJ
-1.0137 -1.1116 TD
[(treatment)-470(of)-468.7(hypertension,)-468.3(in)-463.1(which)-468.4(a)-468.8(specic)-466(Ayurvedic)]TJ
T*
[(herbalmineral)-344.2(formula)-338.5(was)-339.2(recommended)-347.5(to)-336.4(50.6%)-337.2(of)-336.2(the)]TJ
0 -1.1174 TD
(patients.)Tj
7.3823 0 0 6.5614 95.2441 236.9763 Tm
(10)Tj
9.843 0 0 9.843 107.0929 232.611 Tm
[(On)-452.3(subgroup)-457.8(analysis,)-452.2(use)-459.3(of)-451.4(the)-453.8(formula)-453.7(was)]TJ
-4.579 -1.1116 TD
[(associated)-389.9(with)-391.4(greater)-391.4(reductions)-387.8(in)-388.2(blood)-385.8(pressure,)-388.5(com-)]TJ
T*
[(pared)-416.7(with)-420.2(those)-415.5(who)-413.1(had)-419.2(not)-412.4(been)-421.4(given)-415.7(the)-413.5(supplement)]TJ
0 -1.1174 TD
[(\(unpublished)-463.7(data\).)-466.4(Herbs)-468.1(in)-463.1(the)-459.6(formula,)-468.6(including)]TJ
/F6 1 Tf
22.3419 0 TD
(Rau-)Tj
-22.3419 -1.1116 TD
[(wola)-317.7(serpentina)]TJ
/F5 1 Tf
6.9923 0 TD
(,)Tj
/F6 1 Tf
.5645 0 TD
[(Rosa)-316.4(vinca)]TJ
/F5 1 Tf
4.4926 0 TD
[(,)-314.5(and)]TJ
/F6 1 Tf
2.3212 0 TD
[(Convolvulu)-8.9(s)-311.9(pluricaulis)]TJ
/F5 1 Tf
9.6705 0 TD
(,)Tj
-24.041 -1.1116 TD
[(each)-244(have)-242.9(a)-238.4(long)-240.7(history)-238.1(of)-238.3(use)-246.2(in)-238.5(Ayurvedic)-243.6(management)-242.9(of)]TJ
0 -1.1174 TD
[(patients)-397.2(with)-397.2(hypertension.)]TJ
7.3823 0 0 6.5614 171.496 171.2692 Tm
(1113)Tj
9.843 0 0 9.843 193.8897 166.8472 Tm
[(Also)-391.1(in)-394(the)-396.2(formula,)]TJ
/F6 1 Tf
8.893 0 TD
(Rosa)Tj
-22.2901 -1.1116 TD
(centifolia)Tj
/F5 1 Tf
4.1585 0 TD
[(is)-353.5(commonly)-358.2(used)-356.7(in)-359.4(Ayurvedic)-358.8(formulas)-356.7(for)-354.6(in-)]TJ
-4.1585 -1.1116 TD
[(ammatory)-463.9(conditions)-455.9(and)]TJ
/F6 1 Tf
11.6231 0 TD
[(Tribulus)-463.5(terrestris)]TJ
/F5 1 Tf
7.5107 0 TD
(,)Tj
/F6 1 Tf
.7084 0 TD
(Terminalia)Tj
-19.8422 -1.1174 TD
(arjuna)Tj
/F5 1 Tf
2.6667 0 TD
[(,)-354.8(and)]TJ
/F6 1 Tf
2.4133 0 TD
[(Boerhaavia)-360.1(diffusa)]TJ
/F5 1 Tf
8.1212 0 TD
[(each)-359.2(increase)-358.9(diuresis.)]TJ
7.3823 0 0 6.5614 282.6141 138.3874 Tm
(1417)Tj
9.843 0 0 9.843 62.022 123.0236 Tm
[(Expanding)-513.5(on)-503.3(the)-511.4(aforementioned)-511.1(observational)-513.3(ndings,)]TJ
0 -1.1116 TD
[(the)-367.5(authors)-360.1(designed)-368.2(the)-361.7(presen)-8.7(t)-358.3(study)-368.3(to)-359.4(\(1\))-366.1(prospectively)]TJ
T*
[(evaluate)-359.3(the)-355.9(Ayurvedic)-358.8(herbalmineral)-361.5(formula)-361.5(based)-359(on)-353.5(a)]TJ
0 -1.1174 TD
[(comprehensive)-728.6(set)-718.6(of)-722.1(objective)-722.2(safety)-723(and)-724.4(tolerability)]TJ
0 -1.1116 TD
[(measures;)-423.3(\(2\))-423.7(assess)-422.9(patient-reported)-425.9(outcomes)-421.2(during)-421.4(ex-)]TJ
T*
[(tended)-412.2(use)-413.2(of)-411.1(the)-407.8(supplement;)-413.3(and)-413.4(\(3\))-412.2(describe)-409.6(adherence)]TJ
0 -1.1174 TD
[(among)-336.2(adults)-336.1(with)-333.8(pre-)-333.8(and)-332.8(stage)-336.1(I)-335.1(hypertension.)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 313.0582 725.7825 Tm
[(Materials)-337.3(and)-335.3(Methods)]TJ
/F14 1 Tf
0 -1.8336 TD
[(Study)-338.6(design)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 692.9006 Tm
[(A)-347.5(single-arm,)-346.3(open-label)-348.8(clinical)-346.9(trial)-341.1(designed)-345.1(to)-347.9(assess)]TJ
-1.0137 -1.1116 TD
[(safety)-273.8(and)-275.2(tolerability)-275.5(by)-267.1(prospectively)-277.2(assessing)-276.5(changes)-270.2(in)]TJ
0 -1.1174 TD
[(clinical)-364.2(laboratory)-359.1(biomarkers,)-363.5(validated)-365.1(questionnaires)-358.7(for)]TJ
0 -1.1116 TD
[(depression)-347.1(and)-344.3(sleep,)-345.3(clinical)-341.1(AEs,)-342.7(and)-344.3(vital)-341.1(signs)-345.1(was)-345(im-)]TJ
T*
[(plemented.)-623.1(Primary)-626.3(measures)-623.6(were)-618.1(dened)]TJ
/F6 1 Tf
19.3872 0 TD
[(a)-623.1(priori)]TJ
/F5 1 Tf
4.0721 0 TD
(as)Tj
-23.4593 -1.1174 TD
[(chang)-7.8(es)-544.6(in)-549.5(\(1\))-550.4(sodium,)-546.9(potassium,)-551.3(calcium,)-551.8(magnesium)-8.9(,)]TJ
0 -1.1116 TD
[(aspart)-8.8(ate)-322.5(aminotransferase)-335.5(\(AST\),)-327.6(alanine)-328.2(aminotransferase)]TJ
T*
[(\(ALT\),)-392.3(estimated)-395(glomerular)-394.9(ltration)-391.5(rate)-387(\(eGFR\),)-393(b-type)]TJ
T*
[(natriuretic)-546(peptide)-540.2(\(NT-proBNP\);)-541.2(and)-540.1(\(2\))-538.9(Patient)-540.2(Health)]TJ
0 -1.1174 TD
[(Questionnai)-9.8(re)-302.8(\(PHQ-9)-8.1(\)-measured)-309.2(mood)-305.1(scores.)-311.5(Participants)]TJ
0 -1.1116 TD
[(were)-428(rst)-418.8(screened)-427.9(for)-423.7(eligibility)-423.1(by)-422.7(phone)-421.4(and)-419.2(then)-426.2(con-)]TJ
T*
[(rmed)-376.3(with)-374.2(an)-372(in-person)-373.8(clinical)-375.7(screening)-376.2(visit.)-377.8(Once)-376.2(en-)]TJ
0 -1.1174 TD
[(rolled,)-374.3(participants)-368.3(returned)-374.1(for)-366.1(a)-365.1(baseline)-375.2(visit,)-366.2(a)-365.1(3-month)]TJ
0 -1.1116 TD
[(midpoint)-546.1(visit,)-539(and)-540.1(a)-543.7(6-month)-538.9(closure)-545.6(visit.)-539(Participants)]TJ
T*
[(were)-428(contacted)-429.5(by)-422.7(phone)-421.4(between)-426.9(study)-425.9(visits.)-424.7(All)-424.9(study-)]TJ
0 -1.1174 TD
[(related)-241.8(operations)-243.8(were)-238(conducted)-238.2(at)-239.6(the)-235(National)-242.8(University)]TJ
0 -1.1116 TD
[(of)-313.2(Natural)-310.6(Medicine)-313(\(NUNM\).)-313(This)-310.8(study)-304.9(was)-310.4(approved)-310.6(by)]TJ
T*
[(the)-350.2(Institutiona)-9.1(l)-346.8(Review)-350.8(Board)-353.3(at)-349.1(NUNM)-353.5(and)-350(registered)-348.6(at)]TJ
T*
[(Clinc)-8(alTrials.gov)-336(\(NCT02452749\).)]TJ
/F14 1 Tf
8.9663 0 0 8.9663 313.0582 467.5463 Tm
[(Participants)-340.2(and)-329.4(recruitment)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 451.1054 Tm
[(Adults)-514.4(ages)-513.4(1875)-512.4(years)-514.5(with)-512.4(blood)-512.5(pressure)-511.8(meeting)]TJ
-1.0137 -1.1174 TD
[(JNC)-396.7(7)-392.8(criteria)-392.8(for)-394.9(prehypertension)-394.4(or)-393.8(stage)-393.7(I)-392.7(hypertension)]TJ
0 -1.1116 TD
[(\(120139)-170.1(mmHg)-675.9(systolic)-678.1(and/or)-676(8099)-166.8(mmHg)-675.9(diastolic\))]TJ
T*
[(were)-364.7(recruited)-359.2(from)-356.9(the)-355.9(Portland,)-359.1(OR,)-358.9(metropolitan)-362.9(area.)]TJ
7.3823 0 0 6.5614 544.8187 422.5889 Tm
(18)Tj
9.843 0 0 9.843 313.0582 407.2818 Tm
[(Target)-338.5(enrollment)-337.5(was)]TJ
/F6 1 Tf
9.5323 0 TD
(n)Tj
/F8 1 Tf
.6681 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
(30.)Tj
-9.9067 -1.1174 TD
[(Participants)-512.2(with)-512.4(the)-505.7(follow)-7.7(ing)-504.5(were)-514.4(excluded:)-509(resting)]TJ
-1.0137 -1.1116 TD
[(heart)-399.6(rate)]TJ
/F8 1 Tf
4.314 0 TD
(<)Tj
/F5 1 Tf
.5529 0 TD
[(50)-393.9(beats)-399.4(per)-396.1(minute)-400.9(\(bpm\))-398.3(or)]TJ
/F8 1 Tf
12.7923 0 TD
(<)Tj
/F5 1 Tf
.5529 0 TD
[(45)-163.5(bpm)-396.2(in)-399.7(ath-)]TJ
-18.2122 -1.1116 TD
[(letes;)-268.3(serum)-266.9(sodium,)-264.6(potassium,)-269(or)-267.1(calcium)-266.1(levels)-268.2(outside)-262.4(of)]TJ
0 -1.1174 TD
[(laboratory)-411(reference)-413(ranges;)-407.4(elevated)-411.1(AST)-408.4(or)-405.3(ALT;)-411(eGFR)]TJ
/F8 1 Tf
0 -1.1116 TD
()Tj
/F5 1 Tf
.5529 0 TD
[(60)-169.2(mL/min;)-380.4(PHQ-9)]TJ
/F8 1 Tf
8.0578 0 TD
()Tj
/F5 1 Tf
.72 0 TD
[(10;)-372.1(initiation)-381.6(of,)-374.2(or)-376.5(changes)-379.6(to,)-380.1(pre-)]TJ
-9.3307 -1.1116 TD
[(scription)-541.1(blood)-541.3(pressure-lowering)-541.2(medications)-541.2(or)-537.8(thyroid)]TJ
0 -1.1174 TD
[(medications)-276.2(within)-272.8(the)-275.3(previous)-269.1(month;)-273(use)-275(of)]TJ
/F7 1 Tf
19.0013 0 TD
(b)Tj
/F5 1 Tf
.8236 0 TD
(blockers,)Tj
/F7 1 Tf
3.9166 0 TD
(a)Tj
/F5 1 Tf
-23.7415 -1.1116 TD
[(blockers,)-648(digoxin,)-639.2(levodopa,)-642.5(antidepressant)-647.9(medications,)]TJ
T*
.012 Tc
[(ant)5(i)-.7(p)5.1(s)-.4(y)5.1(c)-1.8(ho)5.1(ti)5(c)-364.6(m)-1.8(edi)5(c)-1.8(atio)5.1(ns)5.3(,)-365.8(s)-.4(edativ)5.1(es)5.3(,)-365.8(t)-.7(r)5.2(a)-1.8(n)5.1(q)-.6(u)5.1(ili)5(zers)5.3(,)]TJ
/F6 1 Tf
21.6162 0 TD
.0132 Tc
[(B.)-358.9(dif)6.2(-)]TJ
-21.6162 -1.1116 TD
.0127 Tc
[(fus)6(a)]TJ
/F5 1 Tf
1.7106 0 TD
0 Tc
(,)Tj
/F6 1 Tf
.6105 0 TD
.0072 Tc
[(C.)-353.3(pl)-5.5(ur)-5.2(i)-5.5(c)-.8(a)-5.4(u).3(l)-5.5(i).2(s)]TJ
/F5 1 Tf
5.7367 0 TD
0 Tc
(,)Tj
/F6 1 Tf
.6105 0 TD
.0116 Tc
[(R.)-348.9(serp)4.7(en)4.7(tin)4.7(a)]TJ
/F5 1 Tf
5.5639 0 TD
0 Tc
(,)Tj
/F6 1 Tf
.6048 0 TD
.0134 Tc
[(R.)-341.4(ce)5.4(nti)6.4(f).7(o)6.5(l).7(i)6.4(a)]TJ
/F5 1 Tf
5.1377 0 TD
0 Tc
(,)Tj
/F6 1 Tf
.6105 0 TD
.0085 Tc
[(R.)-352(vinc)-5.3(a)]TJ
/F5 1 Tf
3.4616 0 TD
0 Tc
(,)Tj
/F6 1 Tf
-24.0468 -1.1174 TD
.0126 Tc
[(T.)-250(a)5.7(r).2(ju)5.7(na)]TJ
/F5 1 Tf
3.8014 0 TD
0 Tc
(,)Tj
/F6 1 Tf
.5126 0 TD
.0117 Tc
[(T.)-245.2(terrest)4.7(ris)]TJ
/F5 1 Tf
4.8382 0 TD
.0131 Tc
[(,)-249.5(o).5(r)-247.2(c)5.1(or)6.3(al)-247.3(po)6.2(wd)6.2(er)-247.2(wi)6.1(th)6.2(in)-247.2(t)6.1(h).5(e)-248.3(p).5(r)6.3(e)-.7(v)6.2(i).4(ou)6.2(s)]TJ
-9.1522 -1.1116 TD
.0072 Tc
[(2)-529.5(m)-6.6(on)-5.4(th)-5.4(s;)-529.7(o)-5.4(r)-523.8(p)-5.4(a)-.8(r)-5.4(t)-5.5(ic)-6.6(ip)-5.4(at)-5.5(i)-5.5(o).3(n)-529.6(i).2(n)-529.5(a)-6.6(no)-5.4(th)-5.4(er)-529.5(i)-5.5(n).3(t)-5.5(e)-.8(r)-5.4(v).3(e)-6.6(n)-5.4(ti)-5.5(on)-5.4(al)-529.7(r)-5.4(e)-.8(-)]TJ
T*
.0123 Tc
[(search)-334.4(s)5.6(t)-.4(u)5.4(d)-.3(y)-328.6(w)-1.2(it)5.3(hi)5.3(n)-334.4(t)5.3(he)-329.8(pr)5.5(ev)5.4(io)5.4(us)-328.4(mo)5.4(nth)5.4(.)]TJ
1.0137 -1.1174 TD
.0121 Tc
[(Parti)5.1(c)-1.7(i)5.1(p)-.5(ants)-582.1(were)-583.4(excl)5.1(ud)5.2(ed)-582.2(if)-582.2(th)5.2(ey)-582.2(had)-582.2(a)-589.2(h)5.2(i)-.6(s)5.4(t)-.6(or)5.3(y)-588(o)5.2(f)]TJ
-1.0137 -1.1116 TD
0 Tc
[(ca)18.5(rd)26.6(io)20.7(va)25.4(sc)19.9(ul)26.5(ar)-596.6(di)20.7(se)25.6(as)19.9(e)15(,)-608.2(he)25.4(ar)19.7(t)-606(s)0(u)21(r)16.2(ge)19.7(ry)26.6(,)-608.2(c)0(a)24.3(r)0(d)20.9(i)0(a)25.3(c)-607(ar)19.7(rh)26.6(yt)20.7(hm)25.4(ia)19.6(,)]TJ
T*
[(pa)19.7(ce)24.3(ma)18.4(k)16.2(e)0(r)-233.7(p)0(l)20.7(a)0(c)24.3(e)0(m)18.5(e)15(nt)20.7(,)-245.3(a)15(bn)20.8(or)26.6(ma)18.4(l)-243.1(e)0(l)25.3(e)0(c)18.5(t)16(ro)20.9(ca)24.3(rd)20.9(io)26.5(gr)20.9(am)24.2(,)-245.3(a)0(b)19.7(n)16.2(or)20.9(m)15(a)0(l)]TJ
0 -1.1174 TD
[(ec)18.5(ho)26.6(ca)18.5(rd)26.6(io)20.7(gr)26.6(am)18.5(,)-400.8(k)0(i)26.5(d)0(n)20.8(e)0(y)-389.3(d)0(i)20.7(s)0(e)25.6(a)0(s)19.9(e)0(,)-391.6(c)0(h)25.4(r)0(o)20.9(n)0(i)26.5(c)-405.4(li)26.3(ve)19.7(r)-404.2(d)16.2(is)20.9(ea)24.3(se)19.9(,)-400.8(g)0(a)19.7(l)16(l-)]TJ
0 -1.1116 TD
[(bl)20.7(ad)25.4(de)19.7(r)-231.5(d)16.2(is)20.9(ea)24.3(se)19.9(,)-228.1(b)0(o)20.8(w)15.3(el)-222.4(d)16.2(i)0(s)20.9(e)0(a)24.3(s)0(e)19.9(,)-228.1(ul)20.7(c)15(e)0(r)19.7(s)0(,)-217.4(a)0(l)25.3(c)0(o)19.7(h)0(o)26.6(l)0(i)20.6(s)0(m)25.6(,)-233.8(o)16.2(b)0(s)21(t)0(r)20.7(u)16.2(ct)19.5(i)16.1(v)0(e)]TJ
T*
[(sl)20.9(ee)24.3(p)-490.7(a)0(p)19.7(n)16.2(ea)18.5(,)-487.2(P)0(a)25.6(r)0(k)20.9(i)0(n)20.7(s)16.4(on)20.8(s)-474.3(di)20.7(se)25.6(as)19.9(e,)-478(de)25.4(pr)20.9(es)19.9(s)16.4(i)0(o)20.7(n)0(,)-476.8(p)0(h)26.6(e)0(o)19.7(c)15(hr)20.9(om)25.4(o-)]TJ
0 -1.1174 TD
[(cy)19.7(to)26.5(ma)18.4(,)-239.6(o)0(r)-232.6(m)0(a)24.2(l)0(i)20.6(g)0(n)26.6(a)0(n)19.7(c)15(y)-243(\()0(w)20(i)0(t)26.3(h)0(i)20.7(n)-243(th)26.5(e)-244.2(p)0(r)20.9(e)15(vi)20.7(ou)26.6(s)-242.8(5)-243(ye)19.7(ar)25.5(s\))21.1(;)-243.1(r)0(e)25.5(p)0(o)20.8(r)0(t)26.5(e)0(d)]TJ
0 -1.1116 TD
.0111 Tc
[(c)11.1(o)30.8(n)11.1(s)32.1(u)27.3(m)11.1(p)30.7(t)27.2(i)11.1(o)31.8(n)-214.6(o)4.2(f)-237.6(m)-2.7(o)4.2(r)-1.5(e)-238.8(t)4.1(han)-237.7(1)-1.5(4)-237.7(a)3.1(lcoho)4.2(li)4.1(c)-238.8(b)-1.5(everages)-237.5(per)-231.9(w)-2.4(eek,)]TJ
T*
.0124 Tc
[(smo)5.5(k)-.2(i)5.4(n)-.2(g)-455.2(o)-.2(r)-455.2(t)-.3(ob)5.5(acco)-455.2(us)5.7(e,)-457.6(il)5.4(li)5.4(ci)5.4(t)-461.1(o)5.5(r)-461(r)-.2(ecr)5.6(e)-1.4(ati)5.4(onal)-461.1(d)5.5(ru)5.5(g)-461(u)5.5(se.)]TJ
T*
.0072 Tc
[(L)-6.6(a)-.8(c)-6.6(t)-5.5(at)-5.5(in)-5.4(g)-443.2(o)-5.4(r)-443.1(p)-5.4(re)-6.6(gn)-5.4(a)-6.6(n).3(t)-449(w)-.5(o)-5.4(m)-.9(e)-6.6(n).3(,)-445.5(o)-5.4(r)-443.1(w)-6.3(om)-6.6(en)-448.9(pl)-5.5(an)-5.4(ni)-5.5(ng)-448.9(pr)-5.4(e)-6.6(g).3(-)]TJ
0 -1.1174 TD
.0122 Tc
[(nan)5.3(c)-1.6(y)-311.4(d)5.3(uri)5.2(ng)-311.4(t)5.2(h)-.4(e)-312.6(s)-.2(t)5.2(udy)-311.4(p)5.3(e)-1.6(r)5.4(i)-.5(od)5.3(,)-313.8(w)4.5(ere)-312.6(e)4.2(xclu)5.3(ded.)-313.8(Also)5.3(,)-313.8(t)5.2(hos)5.5(e)]TJ
0 -1.1116 TD
.0124 Tc
[(wit)5.4(h)-391.9(a)-387.3(k)-.2(n)5.5(o)-.2(wn)-386.1(in)5.5(to)5.5(leran)5.5(c)-1.4(e)-387.3(o)-.2(r)-386.1(a)-1.4(ll)5.4(er)5.6(gy)-386.1(to)-391.9(i)5.4(n)-.2(g)5.5(r)-.2(edient)5.4(s)-391.7(i)5.4(n)-391.9(t)-.3(h)5.5(e)]TJ
T*
.013 Tc
[(stu)6.1(d).4(y)-327.9(s).6(u)6.1(ppl)6(em)4.9(en)6.1(t.)]TJ
1.0137 -1.1174 TD
0 Tc
[(Recruitment)-530.8(approaches)-528.1(included)-529.8(newspaper)-532.4(advertise-)]TJ
-1.0137 -1.1116 TD
[(ments)-7.8(,)-372.1(online)-370.9(advertisements,)-381.8(and)-373.1(yers.)-378.3(In)-370.8(addition,)-376.7(elec-)]TJ
T*
[(tronic)-393.9(health)-395.1(records)-395.7(of)-393.8(consenting)-393.5(patients)-397.2(of)-388.1(the)-396.3(NUNM)]TJ
0 -1.1174 TD
[(Healt)-9(h)-312.1(Center)-321.1(were)-318.6(queried.)-318.8(Potentially)-320.2(eligible)-316.9(individuals)]TJ
0 -1.1116 TD
[(were)-382(mailed)-373.3(an)-377.7(invitation)-375.7(letter)-372.1(and)-378.8(recruitment)-380(yer)-374(on)-370.8(a)]TJ
T*
[(rollin)-7(g)-329.4(basis.)]TJ
/F11 1 Tf
8.9663 0 0 8.9663 62.022 749.6502 Tm
(250)Tj
48.2817 0 TD
[(RYAN)-335.1(ET)-338.7(AL.)]TJ
ET
endstream
endobj
44 0 obj
<>stream
/GS1 gs
BT
/F14 1 Tf
8.9663 0 0 8.9663 59.7543 725.7825 Tm
0 0 0 rg
0 Tc
0 Tw
[(Study)-338.6(intervention)]TJ
/F5 1 Tf
9.843 0 0 9.843 69.7323 709.3416 Tm
[(The)-437.6(intervention,)-439.9(Carditone)]TJ
/F8 1 Tf
7.3823 0 0 6.5614 182.948 713.7069 Tm
()Tj
/F5 1 Tf
9.843 0 0 9.843 188.7874 709.3416 Tm
[(,)-435.4(was)-437.1(a)-440(supplement)-440.9(manu-)]TJ
-13.1091 -1.1116 TD
[(factured)-242.8(and)-240.6(supplied)-240.4(by)-238.3(Ayush)-236.6(Herbs,)-241.1(Inc.)-244(\(Redmond,)-240.3(WA\))]TJ
0 -1.1174 TD
[(in)-284.6(60)-284.4(caplet)-286.8(bottles.)-289(Participants)-287.5(were)-289.8(asked)-284.1(to)-284.6(take)-289.1(1)-283.3(caplet)]TJ
0 -1.1116 TD
[(nightly)-365.2(before)-366(bed.)-359.2(The)-362.8(supplement)-366(contains)-362.5(the)-361.7(following)]TJ
T*
[(ingredients)-544.5(in)-538(each)-543.5(caplet:)]TJ
/F6 1 Tf
11.9284 0 TD
[(R.)-541.4(centifolia)]TJ
/F5 1 Tf
5.2068 0 TD
(,)Tj
/F6 1 Tf
.7891 0 TD
[(B.)-541.4(diffusa)]TJ
/F5 1 Tf
4.1355 0 TD
[(,)-533.3(and)]TJ
/F6 1 Tf
-22.0597 -1.1174 TD
[(Dendrogyra)-296.1(cylindrus)]TJ
/F5 1 Tf
9.1982 0 TD
[(\(coral)-291.2(powder\))-291.9(as)-291.1(a)-290.2(proprietary)-296.8(blend)]TJ
-9.1982 -1.1116 TD
[(\(350)-171.4(mg\),)-618.5(magnesium)-625.2(aspartate)-625.1(\(200)-165.6(mg\),)]TJ
/F6 1 Tf
18.4138 0 TD
[(C.)-621.9(pluricaulis)]TJ
/F5 1 Tf
-18.4138 -1.1116 TD
[(\(100)-171.4(mg\),)]TJ
/F6 1 Tf
4.2852 0 TD
[(T.)-419.1(arjuna)]TJ
/F5 1 Tf
4.3025 0 TD
[(\(100)-171.4(mg\),)]TJ
/F6 1 Tf
4.2852 0 TD
[(T.)-419.1(terrestris)]TJ
/F5 1 Tf
5.3047 0 TD
[(\(100)-165.6(mg\),)-422.6(low-)]TJ
-18.1776 -1.1116 TD
(reserpine)Tj
/F6 1 Tf
4.026 0 TD
[(R.)-345.5(serpentina)]TJ
/F5 1 Tf
5.7885 0 TD
[(\(50)-164.5(mg\),)-347.8(and)]TJ
/F6 1 Tf
5.5063 0 TD
[(R.)-345.5(vinca)]TJ
/F5 1 Tf
3.7323 0 TD
[(\(25)-170.3(mg\).)-347.8(T)20.8(h)16.2(e)]TJ
-19.0531 -1.1174 TD
-.0164 Tc
[(man)5.5(ufactu)5.5(r)-.2(ers)-437.8(g)-.2(r)5.6(o)-.2(w)-438.8(t)-.3(he)-439.1(herbs)-437.8(in)-438(th)5.5(e)-444.9(f)5.6(ormula)-439.1(o)-.2(n)-438(f)-.2(arms)-437.8(th)5.5(at)]TJ
0 -1.1116 TD
-.016 Tc
[(they)-305.1(own)-305.1(a)4.8(nd)-305.1(pro)5.9(ces)6.1(s)-304.9(t).1(hem)-300.5(i).1(n)-305.1(t).1(h)5.9(e)-1(ir)-305(pl)5.8(ant)-305.2(i)5.8(n)-305.1(N)-.7(ag)5.9(rota)-300.5(B)-.8(ag)5.9(wan,)]TJ
T*
-.0166 Tc
[(Himach)5.3(al)-340.4(Prades)5.5(h,)-342.6(In)5.3(dia.)-342.6(Th)5.3(e)-341.4(s)-.2(upp)5.3(lement)-340.4(is)-340(manu)5.3(factured)-340.2(i)-.6(n)]TJ
0 -1.1174 TD
-.0161 Tc
[(the)-363.9(U)-.8(nit)5.7(e)-1.1(d)-368.5(S)6(tat)5.7(e)-1.1(s)-368.3(i)0(n)-362.8(a)-369.7(Go)5.8(od)-368.5(Manuf)5.9(act)5.7(uri)5.7(ng)-368.5(Pr)5.9(act)5.7(ice-certi)6(ed)]TJ
0 -1.1116 TD
-.0167 Tc
[(facilit)5.1(y.)-394.5(The)-393.3()-.4(ni)5.1(shed)-397.9(sup)5.2(p)-.5(le)]TJ
11.1911 0 TD
-.0165 Tc
[(ment)-397.9(was)-397.5(a)-1.5(n)5.4(a)-1.5(ly)5.4(zed)-392(for)-391.9(reserpi)5.3(ne)]TJ
-11.1911 -1.1116 TD
-.0163 Tc
[(con)5.6(t)-.2(ent)-679.9(v)5.6(ia)-680.9(hig)5.6(h-perfo)5.6(rmance)-680.9(li)5.5(qui)5.5(d)-685.5(c)4.5(hro)5.6(mat)5.5(ogr)5.7(aphy)-679.8(and)]TJ
0 -1.1174 TD
-.0161 Tc
[(lev)5.8(e)-1.1(ls)-397.1(were)-392.7(bel)5.7(o).1(w)-398.2(t)0(h)5.8(e)-398.5(lo)5.8(wer)-391.5(limit)-397.5(o)5.8(f)-397.3(det)5.7(ect)5.7(ion)-391.6(\()]TJ
/F8 1 Tf
19.4736 0 TD
0 Tc
(<)Tj
/F5 1 Tf
.5357 0 TD
-.0164 Tc
[(0.01)5.5(%;)-397.8(I)5.6(n)-.2(-)]TJ
-20.0092 -1.1116 TD
-.0168 Tc
[(tert)5(ek,)-267.9(C)-1.6(hamp)5.1(aign)5.1(,)-273.7(I)-.6(L\).)-273.7(L)4(ead)-271.3(anal)5(ysis)-271.1(sh)5.1(owed)-271.3(that)-271.5(levels)-271.1(were)]TJ
/F8 1 Tf
T*
0 Tc
(<)Tj
/F5 1 Tf
.5357 0 TD
-.0166 Tc
[(0.2)-167.4(p)5.3(pm)-329.9(\()-86.8(M)4.4(icr)5.4(o)-334.5(Qu)5.3(ali)5.2(t)-.5(y)-334.5(L)4.2(abs)5.5(,)-336.8(I)5.4(n)-.4(c.,)-331.1(B)-1.4(u)5.3(rbank,)-331.1(CA\).)]TJ
/F14 1 Tf
8.9663 0 0 8.9663 59.7543 500.8817 Tm
0 Tc
[(Data)-337.7(collection)]TJ
/F5 1 Tf
9.843 0 0 9.843 69.7323 484.4408 Tm
.0073 Tc
[(F)-5.2(a)-.7(s)-5.1(t).3(i)-5.4(n)-5.3(g)-454.6(b)-5.3(lo)-5.3(od)-460.3(s)-5.1(a)-.7(m)-6.5(p).4(l)-5.4(e)-.7(s)-460.1(w)-6.2(er)-5.3(e)-455.7(o)-5.3(bt)-5.4(ai)-5.4(n)-5.3(e)-.7(d)-460.3(b).4(y)-460.3(v).4(e)-6.5(n)-5.3(ip)-5.3(un)-5.3(ct)-5.4(ur)-5.3(e)]TJ
-1.0137 -1.1116 TD
.013 Tc
[(by)-339.4(a)-340.6(c)5(er)6.2(ti)6.3(ed)-339.4(p)6.1(h).4(l)6(e)-.8(b)6.1(o).4(t)6(o).4(m)4.9(i).3(st)6(.)-341.8(V)5.3(it)6(al)-339.6(si)6(gn)6.1(s)-339.2(w)-.5(e)5(r).4(e)-340.6(m)4.9(ea)5(su)6.1(red)-333.7(b).4(y)]TJ
0 -1.1174 TD
.0118 Tc
[(train)4.9(e)-2(d)-363.7(c)3.8(li)4.8(ni)4.8(cal)-363.8(r)-.8(esearch)-363.7(c)3.8(oo)4.9(rdi)4.8(nato)4.9(rs.)-360.2(B)-1.8(l)4.8(o)-.8(o)4.9(d)-363.7(pr)5(es)5.1(sur)5(e)-364.8(and)]TJ
0 -1.1116 TD
.012 Tc
[(res)5.3(t)-.7(i)5(n)-.6(g)-403.8(h)-.6(eart)-403.9(rate)-405(were)-405(meas)5.3(ur)5.2(ed)-403.8(usi)5(n)-.6(g)-403.8(a)-1.8(n)-403.8(O)-1.5(mro)5.1(n)-409.6(d)5.1(i)-.7(g)5.1(ital)]TJ
T*
.0123 Tc
[(blo)5.4(o)-.3(d)-443.8(press)5.6(ure)-445(mo)5.4(ni)5.3(tor)-449.5(\()5.5(HBP-)5.5(13)5.4(00\))-443.8(aft)5.3(e)-1.5(r)-449.5(t)5.3(he)-445(par)5.5(t)-.4(i)5.3(c)-1.5(i)5.3(p)-.3(ant)]TJ
T*
-.02 Tc
[(w)-4.7(a).8(s)-239.8(s)-3.6(eated)-240(for)-239.9(a).8(t)-240.1(l)1.8(e)-5(a).8(st)-240.1(5)-240(m).7(inutes)-245.5(with)-240(the)-5(i)1.8(r)-239.9(b)-3.8(ack)-240(supported,)-242.3(fe)-5(et)]TJ
0 -1.1174 TD
.0118 Tc
[(at)-444.4(o)-.8(n)-438.6(t)-.9(he)-439.7(o)4.9(or,)-440.9(and)-444.3(t)4.8(heir)-444.3(arm)-439.8(s)-.6(u)4.9(ppo)4.9(rt)4.8(ed)-444.3(at)-444.4(h)4.9(e)-2(art)-444.4(l)4.8(ev)4.9(el)4.8(.)]TJ
0 -1.1116 TD
.0123 Tc
[(Th)5.4(ree)-375.9(c)4.3(on)5.4(secu)5.4(tiv)5.4(e)-375.9(r)-.3(ead)5.4(i)-.4(n)5.4(g)-.3(s)-374.5(w)-1.2(ere)-375.9(t)5.3(ak)5.4(en)-374.7(\(at)-374.8(l)-.4(eas)5.6(t)-374.8(1)-374.7(m)-1.5(i)5.3(nut)5.3(e)]TJ
T*
-.02 Tc
[(a)-20(p)-6.1(a)-20(r)-.3(t)-20(\))-310.3(a)-20(n)-.3(d)-326.4(t)-20(he)-20(n)-317.1(a)-20(ve)-20(ra)-20(ge)-20(d.)-322.9(A)-20(l)-5.9(l)-320.7(q)-20(ue)-20(s)-5.9(t)-20(io)-20(nn)-20(ai)-20(re)-20(s)-316.9(w)-20(er)-20(e)-317.1(c)-20(om)-20(pl)-20(et)-20(ed)]TJ
0 -1.1174 TD
.0116 Tc
[(by)-513.6(di)4.6(rect)-513.8(int)4.6(e)-2.2(r)4.8(v)-1(i)4.6(e)-2.2(w.)-516(To)-513.6(as)4.9(ses)4.9(s)-519.2(adh)4.7(e)-2.2(r)4.8(e)-2.2(nce,)-516(u)4.7(n)-1(u)4.7(s)-.8(ed)-519.4(s)4.9(t)-1.1(ud)4.7(y)]TJ
0 -1.1116 TD
.0072 Tc
[(s)-5.2(u)-5.4(pp)-5.4(le)-6.6(me)-6.6(nt)-241.7(wa)-6.6(s)-235.6(r)-5.4(e)-6.6(t).2(u)-5.4(r).4(n)-5.4(e)-.8(d)-241.6(f).4(o)-5.4(r)-241.5(pi)-5.5(ll)-241.7(co)-5.4(un)-5.4(t)-5.5(s)-235.6(a)-6.6(t)-235.9(t)-5.5(h).3(e)-242.7(m)-.9(i)-5.5(d).3(p)-5.4(o).3(i)-5.5(n)-5.4(t)-235.9(a)-6.6(nd)]TJ
T*
.0125 Tc
[(en)5.6(dpo)5.6(in)5.6(t)-334.3(o)5.6(f)-334.1(t)5.5(he)-329.6(tr)5.7(ial.)]TJ
/F15 1 Tf
8.9663 0 0 8.9663 69.7323 341.7448 Tm
0 Tc
[(Clinical)-460.7(laboratory)-456.3(measures.)]TJ
/F5 1 Tf
9.843 0 0 9.843 196.9511 341.7448 Tm
[(Serum)-445.4(samples)-448.7(from)-443.3(the)]TJ
-13.9385 -1.1116 TD
[(screening)-255.2(visit)-247.6(were)-255.2(sent)-247.4(to)-250(Quest)-249.4(Diagnostics)-257.2(\(Seattle,)-252.1(WA\))]TJ
0 -1.1174 TD
[(by)-399.6(courier)-401.8(the)-396.3(day)-401.9(of)-399.6(collection)-400.9(and)-396.1(analyzed)-405.3(for)-400.7(sodium,)]TJ
0 -1.1116 TD
[(potassium,)-395.8(calcium,)-396.3(AST,)-394.5(ALT,)-395.9(and)-390.4(eGFR)-393.2(to)-394(conrm)-394.7(eli-)]TJ
T*
[(gibility;)-264.1(however,)-262(screening)-261(laboratory)-261.2(values)-262.3(were)-261(not)-262.6(used)]TJ
0 -1.1174 TD
[(in)-422.8(any)-419.2(analyses.)-424.4(At)-423.7(subsequent)-422(visits,)-424.7(serum,)-420(plasma,)-422.5(and)]TJ
0 -1.1116 TD
[(whole)-428.1(blood)-426.1(were)-428(shipped)-429.3(to)-422.8(Veridia)-431.6(Diagnostics)-430(\(Round)]TJ
T*
[(Rock,)-246.2(TX\))-235.7(on)-244.1(the)-240.7(day)-240.6(of)-238.3(collection)-245.4(and)-240.6(analyzed)-238.2(for)-245.1(sodium,)]TJ
0 -1.1174 TD
[(potassium,)-436.1(calcium,)-430.8(magnesium,)-432.8(NT-proBNP,)-431.8(AST,)-429.1(ALT,)]TJ
0 -1.1116 TD
[(eGFR,)-287.2(total)-283.5(cholesterol,)-289.9(low-density)-285(lipoprotein)-284.5(cholesterol,)]TJ
T*
[(high-density)-711.5(lipoprotein)-710.7(cholesterol,)-716.1(triglycerides,)-712.7(high-)]TJ
T*
[(sensitivity)-387.9(cardiac)-386.8(troponin-I,)-389(endothelin,)-385.8(cystatin)-385.7(C,)-385.7(high-)]TJ
0 -1.1174 TD
[(sensitivity)-578(C-reactive)-575.6(protein,)-571.2(interleukin)-573.6(\(IL\)-6,)-575.6(IL-17a,)]TJ
0 -1.1116 TD
[(tumor)-473.4(necrosis)-477.4(factor-)]TJ
/F7 1 Tf
9.3019 0 TD
(a)Tj
/F5 1 Tf
.5472 0 TD
[(,)-475.7(white)-468.6(and)-476.8(red)-471(blood)-472.2(cell)-473.5(\(RBC\))]TJ
-9.8491 -1.1116 TD
[(count,)-338.5(platelet)-335.4(count,)-332.8(hemoglobin,)-339.7(and)-332.8(hematocrit.)]TJ
/F15 1 Tf
8.9663 0 0 8.9663 69.7323 166.1669 Tm
[(Participant-reported)-366.4(outcomes.)]TJ
/F5 1 Tf
9.843 0 0 9.843 201.6566 166.1669 Tm
[(AEs)-362.3(were)-364.7(monitored)-363.9(by)]TJ
-14.4165 -1.1116 TD
[(specic)-379.6(interviews)-383(during)-375.3(scheduled)-382(3-)-376.5(and)-378.8(6-month)-377.7(visits)]TJ
0 -1.1174 TD
[(and)-488.3(by)-486(phone)-484.7(calls)-485.9(between)-484.5(visits.)-488.1(Participants)-489.1(were)-485.6(en-)]TJ
0 -1.1116 TD
[(couraged)-421.2(to)-417(report)-416.8(any)-419.2(AE)-419(between)-421.1(study)-414.4(visits)-421.3(or)-416.9(phone)]TJ
T*
[(calls)-480.2(by)-480.3(contacting)-475.7(a)-480.3(clinical)-479.4(research)-479.7(coordinator)-481.2(or)-474.5(the)]TJ
0 -1.1174 TD
[(principal)-398.5(investigators.)-400.3(A)-393.6(91-item)-396.2(standardized)-398(monitoring)]TJ
0 -1.1116 TD
[(questionnai)-8.9(re,)-369.6(developed)-376.4(according)-376.4(to)-376.7(the)-373.2(National)-375.3(Cancer)]TJ
T*
[(Institutes)-756.3(Common)-747.4(Terminology)-747.4(Criteria)-755.5(for)-746.2(Adverse)]TJ
0 -1.1174 TD
-.0153 Tc
[(Ev)6.6(e)5.5(n).9(t)6.5(s)-240.8(v)6.6(4).9(.)10.1(0).9(,)-237.6(w)5.8(as)-235.1(ad)6.6(m)5.4(i).8(n)6.6(i)6.5(st)6.5(er)6.7(e)5.5(d)-241(a)5.5(t)]TJ
12.8614 0 TD
-.0216 Tc
[(ea)-6.6(ch)-247.3(tri)-5.5(a)-.8(l)-247.5(v).3(is)-5.2(it)-5.5(.)-243.9(A)-.5(d)-5.4(m)-.9(ini)-5.5(s).5(t)-5.5(e)-.8(ri)-5.5(ng)]TJ
-12.8614 -1.1116 TD
-.0218 Tc
[(t)-5.7(h).1(e)-363.9(f)-5.6(or)-5.6(m)-363.9(r).2(eq)-5.6(ui)-5.7(res)-368.3(que)-6.8(ryi)-5.7(n).1(g)-368.5(s).3(ym)-6.8(pto)-5.6(m)-1.1(s)-362.5(i)-5.7(n)-362.7(e)-1(i)-5.7(ght)-368.6(sys)-5.4(t)0(e)-6.8(m)-1.1(s:)-368.6(eye)-6.8(s).3(/)]TJ
T*
0 Tc
[(ea)18.5(rs)15.3(/n)20.7(os)21(e/)19.5(th)15(ro)20.9(at)19.5(,)-291.4(g)0(a)19.7(s)0(t)15.1(r)0(o)20.9(i)0(n)20.7(t)0(e)19.6(s)0(t)15.1(i)0(n)20.7(a)0(l)19.5(,)-291.4(ne)19.7(ur)15.1(ol)20.7(og)20.8(ic)19.6(/m)19.5(us)21(cu)13.9(lo)20.7(sk)21(el)19.5(et)19.6(al)19.5(,)]TJ
25.5097 67.9242 TD
.007 Tc
[(ps)-5.4(y)-5.6(c)-1(h)-5.6(o).1(l)-5.7(o).1(g)-5.6(i)0(c)-6.8(/)-5.7(ge)-6.8(ne)-6.8(ra)-6.8(l,)-249.9(c)-6.8(a)-1(r)-5.6(d).1(i)-5.7(o)-5.6(pu)-5.6(lm)-6.8(on)-5.6(ar)-5.6(y,)-249.9(s)-5.4(k)-5.6(in)-5.6(,)-249.9(g).1(e)-6.8(n).1(i)-5.7(t)0(o)-5.6(u).1(r)-5.6(i)-5.7(na)-6.8(ry)-5.6(,)]TJ
0 -1.1174 TD
.0098 Tc
[(and)-250.5(c)1.8(onstitutional)-250.6(system)-4(s.)]TJ
11.3351 0 TD
.0133 Tc
[(Sy)6.4(mp)6.4(to)6.4(ms)-246.8(ar)6.5(e)-248.1(g).7(r)6.5(a)-.5(d)6.4(e)-.5(d)-247(f).7(r)6.5(o).7(m)-248.2(0)-247(t)6.3(o)]TJ
-11.3351 -1.1116 TD
.6462 Tc
[(5\()639.4(0)]TJ
/F8 1 Tf
2.1656 0 TD
0 Tc
(=)Tj
/F5 1 Tf
.7257 0 TD
.0112 Tc
[(not)-635.1(present;)-635.1(1)]TJ
/F8 1 Tf
6.52 0 TD
0 Tc
(=)Tj
/F5 1 Tf
.7315 0 TD
.0124 Tc
[(mil)5.4(d)-633.8([n)5.5(o)-639.5(i)5.4(nt)5.4(er)5.6(venti)5.4(o)-.2(n)-633.8(r)5.6(eq)5.5(uir)5.6(e)-1.4(d)5.5(])-.2(,)]TJ
-10.1428 -1.1116 TD
0 Tc
(2)Tj
/F8 1 Tf
.6739 0 TD
(=)Tj
/F5 1 Tf
.7315 0 TD
.0073 Tc
[(mo)-5.3(de)-6.5(ra)-6.5(t)-5.4(e)-352.1([)-5.3(a)-6.5(ct)-5.4(iv)-5.3(it)-5.4(i)-5.4(e)-.7(s)-356.5(o)-5.3(f)-356.6(d).4(a)-6.5(i).3(l)-5.4(y)-356.7(li)-5.4(v)-5.3(i).3(n)-5.3(g)-356.7(li)-5.4(mi)-5.4(te)-6.5(d])-5.3(,)-359(3)]TJ
/F8 1 Tf
19.5427 0 TD
0 Tc
(=)Tj
/F5 1 Tf
.7315 0 TD
.0068 Tc
[(se)-7(ve)-7(re)]TJ
-21.6795 -1.1116 TD
.0073 Tc
[(or)-437.3(med)-5.3(i)-5.4(ca)-6.5(ll)-5.4(y)-431.5(s)-5.1(ig)-5.3(ni)-5.4(c)-6.5(an)-5.3(t)-5.4(,)-428.1(b)-5.3(u).4(t)-437.4(n)]TJ
12.9881 0 TD
.0093 Tc
[(ot)-429.7(im)-4.5(me)-4.5(diately)-429.5(l)-3.4(ife)-430.7(t)-3.4(hrea)-4.5(t-)]TJ
-12.9881 -1.1174 TD
.0119 Tc
[(eni)4.9(n)-.7(g)-357.8([)5.1(basic)-353.2(s)-.5(elf)5.1(-)-.7(care)-353.2(li)4.9(mi)4.9(ted)-357.8(o)-.7(r)-352(h)-.7(o)5(s)-.5(pi)4.9(tali)4.9(zatio)5(n)-357.8(r)5.1(e)-1.9(q)5(u)-.7(ir)5.1(ed)5(],)]TJ
0 -1.1116 TD
0 Tc
(4)Tj
/F8 1 Tf
.6566 0 TD
(=)Tj
/F5 1 Tf
.7084 0 TD
[(li)20.6(fe)-325.9(th)20.7(re)19.7(at)19.5(en)19.7(in)15(g,)-321.3(5)]TJ
/F8 1 Tf
7.2976 0 TD
(=)Tj
/F5 1 Tf
.7084 0 TD
[(fa)19.7(ta)19.5(l\))15(.)-331.7(F)0(u)21(r)0(t)20.7(h)0(e)13.9(r)0(m)19.6(o)0(r)20.9(e)0(,)-322.5(A)0(E)18.8(s)-335(we)18.8(re)-325.9(cl)19.6(as)19.9(si)20.9(-)]TJ
-9.371 -1.1116 TD
[(e)19.8(d)-254.5(a)0(s)-245.1(s)0(e)19.9(r)0(i)15(o)0(u)20.8(s)-254.3(or)-244.1(no)20.8(ns)21(er)14(io)20.7(us)-243.9(ba)19.7(se)19.9(d)-254.5(o)0(n)-244.1(F)0(D)14.4(A)-255.4(an)19.7(d)-254.5(F)0(e)19.8(d)0(e)19.7(r)0(a)19.7(l)-254.7(Fo)21(od)]TJ
0 -1.1174 TD
[(Dr)20(ug)-365.1(a)-8(n)-12.6(d)-392.8(C)-13.6(o)-6.9(s)-12.4(m)-8.1(e)-13.8(t)-7(i)-12.7(c)-393.9(A)-13.5(c)-8(t)-398.6(d)-6.9(e)-13.8()-6.7(n)-12.6(i)]TJ
12.7059 0 TD
.0096 Tc
[(tions.)-385.5(A)-3.9(Es)-383(w)-3.9(e)-4.2(re)-384.3(c)-4.2(o)2.7(nsidered)]TJ
-12.7059 -1.1116 TD
.007 Tc
[()46.3().2(s)-5.4(e)-1(r)-5.6(i)-5.7(ou)-5.6(s)46.3()-587.3(i)0(f)-587.3(a)-588.5(pa)-6.8(r)-5.6(t)0(i)-5.7(c)-1(i)-5.7(p).1(a)-6.8(n).1(t)-5.7()-5.6(s)-581.4(o)-5.6(ut)-5.7(c)-6.8(o).1(me)-588.5(h)-5.6(a)-1(d)-587.3(i)0(n)-5.6(c)-1(l)-5.7(u)-5.6(de)-6.8(d)-581.6(t)-5.7(he)]TJ
T*
0 Tc
[(fo)20.9(ll)20.6(ow)20(in)15(g:)-399.8(a)-411.2(l)0(i)20.6(f)0(e)14(-)0(t)20.7(h)0(r)20.9(e)0(a)18.5(t)0(e)19.5(n)0(i)15(n)0(g)-399.6(e)0(x)19.7(p)0(e)19.7(r)0(i)20.7(e)0(n)13.9(c)0(e)18.5(,)-406.6(in)14.9(pa)19.7(ti)20.6(en)19.7(t)-410.2(h)0(o)15.1(s)0(p)21(i)0(t)20.6(a)0(l)19.6(i)0(-)]TJ
0 -1.1174 TD
.0121 Tc
[(z)12.1(a)30.6(t)12.1(i)32.7(o)12.1(n)32.9(,)-221.7(d)-.5(i)5.1(s)-.3(ab)5.2(il)5.1(ity)-242.4(o)5.2(r)-242.4(in)5.2(capaci)5.1(ty,)-239(d)-.5(eat)5.1(h)-.5(,)-239(a)-243.6(co)5.2(ngeni)5.1(tal)-242.6(a)-1.7(n)5.2(o)-.5(mal)5.1(y)]TJ
0 -1.1116 TD
.0123 Tc
[(o)5.4(r)-472.6(bi)5.3(rth)-466.9(d)-.3(ef)5.5(ect,)-469.2(or)-472.6(a)-468(m)-1.5(edical)-467(or)-472.6(su)5.4(rg)5.4(ical)-472.7(i)5.3(n)-.3(terv)5.4(en)5.4(ti)5.3(on)-472.6(t)5.3(o)]TJ
T*
.0121 Tc
[(p)5.2(r)-.5(even)5.2(t)-461.4(o)5.2(ne)-456.7(of)-461.3(t)5.1(h)-.5(ese)-462.5(o)5.2(ut)5.1(co)5.2(mes.)]TJ
7.3823 0 0 6.5614 444.2455 587.0549 Tm
.0138 Tc
(19,20)Tj
9.843 0 0 9.843 465.9022 582.6896 Tm
.0135 Tc
[(All)-454.3(o).9(t)6.5(h).9(e)5.5(r)-459.9(AE)5.5(s)-459.7(w)5.8(er)6.7(e)]TJ
-15.7528 -1.1116 TD
.0072 Tc
[(de)-6.6(s)-5.2(i).2(g)-5.4(n).3(a)-6.6(t).2(e)-6.6(d)-333.7()46.5()-5.4(no)-5.4(ns)-5.2(er)-5.4(i)-5.5(o).3(u)-5.4(s).5(.)-7.7()52.2()]TJ
1.0137 -1.1174 TD
0 Tc
[(T)15(h)0(e)-210.7(9)0(-)15.1(i)0(t)20.6(e)0(m)-206.2(P)0(a)14.1(t)0(i)20.6(e)0(n)19.7(t)-220.1(He)18.8(al)19.6(th)-209.7(Qu)20(es)19.9(ti)20.6(on)15.1(na)19.7(ir)20.7(e)-221.1(\()0(P)21(H)0(Q)19.1(-)0(9)20.9(\))-219.9(wa)18.8(s)-219.8(u)0(s)21(e)0(d)]TJ
-1.0137 -1.1116 TD
[(to)-301.8(as)19.9(se)19.9(ss)-301.3(ch)19.7(an)19.7(ge)13.9(s)-306.2(i)0(n)-301.8(m)0(o)19.6(o)0(d)20.8(.)-314.4(Th)19.6(e)-313.3(P)0(H)20.1(Q)0(-)20(9)-312.1(wa)18.8(s)-311.9(s)0(c)19.9(o)0(r)20.9(e)0(d)-302.9(a)0(s)-302.7(p)0(r)20.9(e)0(v)19.7(i)0(-)]TJ
T*
[(ou)20.8(sl)20.9(y)-306.4(d)0(e)19.7(s)0(c)19.9(r)0(i)20.7(b)0(e)19.7(d)0(.)]TJ
7.3823 0 0 6.5614 374.0598 543.2313 Tm
(21)Tj
9.843 0 0 9.843 384.3778 538.866 Tm
[(An)-291.1(in)20.7(cr)19.7(ea)12.8(se)-291.1(of)]TJ
/F8 1 Tf
6.1629 0 TD
(>)Tj
/F5 1 Tf
.5414 0 TD
[(5)-300.6(p)0(o)15.1(i)0(n)20.7(t)0(s)-290.1(w)0(a)18.8(s)-306.2(de)19.7(n)21(ed)-297.1(as)-291.1(a)]TJ
-14.1746 -1.1174 TD
[(ca)18.5(te)19.5(go)20.8(ri)20.7(ca)12.8(l)-295(c)0(h)19.7(a)0(n)19.7(g)0(e)-291.3(i)0(n)-290.3(m)0(o)19.6(o)0(d)20.8(,)-297.2(an)19.7(d)-300.6(t)0(h)20.7(u)0(s)-290(w)0(a)18.8(s)-300.4(sp)21(ec)18.5(i)20.9(ca)18.5(ll)20.6(y)-300.6(e)0(v)19.7(a)0(l)19.6(u)0(-)]TJ
0 -1.1116 TD
[(at)19.5(ed)-170.4(at)-170.5(th)14.9(e)-180.8(3)0(-)-169.2(a)0(n)19.7(d)-185.4(6-)20.9(mo)19.6(nt)20.7(h)-179.6(v)0(i)20.7(s)0(i)15.1(t)0(s)20.9(.)-182(Ch)19.8(an)19.7(ge)19.7(s)-185.2(i)0(n)-169.4(s)0(l)20.9(e)0(e)18.5(p)-185.4(qu)20.8(al)19.5(it)20.6(y)-179.6(w)0(e)18.8(r)0(e)]TJ
T*
[(as)19.9(se)19.9(ss)15.5(ed)-492.9(wi)19.8(th)-491.9(th)20.7(e)-509.1(P)0(a)19.8(t)0(i)20.6(e)0(n)19.7(t)-502.3(Re)18.6(po)15.1(rt)20.7(ed)-492.9(Ou)20(tc)19.5(om)19.6(e)-509.1(M)0(e)18.8(a)0(s)19.9(u)0(r)20.9(e)-503.3(In)20.9(-)]TJ
0 -1.1174 TD
[(fo)20.9(rm)19.6(at)19.5(io)20.7(n)-335.2(S)0(y)15.2(s)0(t)20.9(e)0(m)-327.1(\()0(P)21(R)0(O)18.9(M)0(I)20(S)0(\))-330.3(S)0(l)20.9(e)0(e)18.5(p)-335.2(Di)19.8(st)20.9(ur)15.1(ba)19.7(nc)19.7(e)-336.3(S)0(h)21(o)0(r)20.9(t)-335.3(Fo)21(rm)]TJ
0 -1.1116 TD
[(8b)20.8(,)-268.4(w)0(h)20(i)0(c)13.8(h)-266(wa)18.8(s)-271.6(s)0(c)19.9(o)0(r)15.1(e)0(d)-256.8(a)0(s)-262.4(p)0(r)20.9(e)0(v)13.9(i)0(o)20.7(u)0(s)21(l)0(y)-261.5(d)0(e)19.7(s)0(c)19.9(r)0(i)20.7(b)0(e)13.9(d)0(.)]TJ
7.3823 0 0 6.5614 491.0739 488.4093 Tm
[(22)24.7(,2)20.4(3)]TJ
/F14 1 Tf
8.9663 0 0 8.9663 310.8472 459.3259 Tm
[(Data)-331.3(analysis)]TJ
/F5 1 Tf
9.843 0 0 9.843 320.8251 442.8849 Tm
[(Continuous)-288.6(measures)-289.6(are)-287.8(presented)-289.8(as)-291.2(mean)-284.4(and)-292.4(standard)]TJ
-1.0137 -1.1116 TD
[(deviation)-433.1(at)-435.5(each)-439.9(time)-433.3(point.)-435.4(Changes)-437.1(from)-437.5(baseline)-438.6(to)-428.6(3)]TJ
T*
[(months)-445.5(and)-448(from)-449.1(baseline)-450.1(to)-445.8(6)-444.6(months)-451.3(were)-445.3(summarized)]TJ
T*
[(using)-253.1(Glasss)-262.7(Delta,)-260.1(a)-255.7(version)-256.4(of)-261.4(Cohens)]TJ
/F6 1 Tf
16.8875 0 TD
(d)Tj
/F5 1 Tf
.7545 0 TD
[(that)-259.3(is)-255.6(computed)]TJ
-17.642 -1.1174 TD
[(as)-366(the)-361.7(change)-367.2(in)-365.2(means)-371.7(divided)-366.2(by)-359.3(baseline)-369.5(standard)-368.1(devi-)]TJ
0 -1.1116 TD
[(ation;)-324.9(standardized)-334.7(differences)-333.4(are)-328.1(referred)-329(to)-330.6(as)-325.7(Cohens)]TJ
/F6 1 Tf
23.7876 0 TD
(d)Tj
/F5 1 Tf
-23.7876 -1.1116 TD
[(in)-244.2(the)-252.3(Results)-245.9(section.)-255.4(Signicance)-247.1(of)-249.8(changes)-252.9(from)-247.5(baseline)]TJ
0 -1.1174 TD
[(was)-385.3(drawn)-381.9(from)-385.7(random)-383.4(intercept)-388.1(models)-383.3(applied)-384.7(to)-382.5(mea-)]TJ
0 -1.1116 TD
[(surements)-341.5(at)-337.6(all)-338.8(three)-336.2(time)-341.1(points.)-338.4(When)-336.1(outcomes)-340.6(showed)]TJ
T*
[(substantial)-463.8(skew)-461.3(or)-457.2(outliers,)-462.8(the)-459.6(authors)-463.8(conducted)-462.8(sensi-)]TJ
0 -1.1174 TD
[(tivity)-525.5(analyses)-530.4(using)-523.8(log)-527.6(transformations)-532.6(of)-526.3(the)-528.7(data,)-528.7(or)]TJ
0 -1.1116 TD
[(omitting)-287(outliers,)-284.3(as)-285.4(appropriate.)-289.9(As)-285.1(part)-287.9(of)-284.4(primary)-286.6(aims)-289(of)]TJ
T*
[(the)-344.4(study,)-342.9(the)-344.4(proportion)-345.3(of)-342(participant)-10.3(s)-340.7(who)-344(met)-345.7(several)]TJ
/F6 1 Tf
23.7876 0 TD
(a)Tj
-23.7876 -1.1116 TD
(priori)Tj
/F5 1 Tf
2.6207 0 TD
[(dened)-291(safety)-291.1(and)-292.4(tolerability)-292.8(criteria)-294.8(at)-285.7(the)-292.6(midpoint)]TJ
-2.6207 -1.1174 TD
[(and)-373.1(trial)-375.6(end)-373.1(visits)-375.2(was)-373.8(calculated.)-377.8(These)-371.7(safety)-377.5(and)-373.1(toler-)]TJ
0 -1.1116 TD
[(ability)-447.1(criteria)-456.1(were)-445.3(as)-452.4(follows:)-447.6(NT-proBNP)]TJ
/F8 1 Tf
19.1107 0 TD
(>)Tj
/F5 1 Tf
.5529 0 TD
[(400)-170.3(pg/mL;)]TJ
-19.6636 -1.1116 TD
[(sodium,)-299.2(potassium,)-303.6(calcium,)-304.1(or)-301.7(magnesium)]TJ
/F8 1 Tf
17.9069 0 TD
()Tj
/F5 1 Tf
.5529 0 TD
[(25%)-303.9(higher)-301.6(or)]TJ
-18.4599 -1.1174 TD
.0132 Tc
[(2)6.3(5).6(%)-455.5(l).5(o)6.3(w)-.3(e)5.2(r)-460.2(th)6.3(an)-454.4(th)6.3(e)-461.4(l)6.2(ab)6.3(or)6.4(ato)6.3(r).6(y)-454.4(r).6(e)5.2(f).6(e)5.2(r).6(en)6.3(ce)-455.6(ra)5.2(ng)6.3(e;)-454.6(AS)6.5(T)-461.4(o)6.3(r)]TJ
0 -1.1116 TD
.0077 Tc
[(AL)-6.1(T)]TJ
/F8 1 Tf
2.2751 0 TD
0 Tc
(>)Tj
/F5 1 Tf
.5587 0 TD
.0123 Tc
[(2)-299.8(t)5.3(imes)-293.9(th)5.4(e)-295.2(upp)5.4(er)-294(l)5.3(a)-1.5(bo)5.4(rato)5.4(ry)-294.1(referen)5.4(c)-1.5(e)-295.2(r)5.5(ang)5.4(e)-1.5(;)-294.2(e)4.3(GFR)]TJ
-2.8338 -1.1116 TD
.0089 Tc
[(de)-4.9(crea)-4.9(se)-310.1(of)]TJ
/F8 1 Tf
5.0109 0 TD
0 Tc
()Tj
/F5 1 Tf
.5587 0 TD
.0116 Tc
[(15)-162.3(mL/min)-306.3(f)4.8(rom)-307.5(b)4.7(a)-2.2(s)4.9(e)-2.2(l)4.6(i)-1.1(ne;)-306.4(i)-1.1(n)4.7(c)-2.2(reas)4.9(e)-307.4(i)-1.1(n)-306.3(P)-.9(HQ-)4.8(9)]TJ
-5.5696 -1.1174 TD
-.022 Tc
[(sc)-7(ore)-398.6(b)-.1(y)]TJ
/F8 1 Tf
3.7553 0 TD
0 Tc
()Tj
/F5 1 Tf
.5357 0 TD
-.0218 Tc
[(5)-391.5(p).1(o)-5.6(i)0(n)-5.6(t)0(s)-391.3(\()-5.6(wit)-5.8(h).1(o)-5.6(u).1(t)-391.6(a)-6.8(lte)-6.8(rna)-6.8(tiv)-5.6(e)-392.7(e)-1(x)-5.6(p).1(l)-5.7(a)-1(na)-6.8(tio)-5.6(n\);)-397.4(s).3(y)-5.6(s).3(to)-5.6(lic)]TJ
-4.291 -1.1116 TD
[(hyp)-5.6(ot)-5.7(ens)-5.4(i)0(on)-305.1(\()]TJ
/F8 1 Tf
5.2874 0 TD
0 Tc
(<)Tj
/F5 1 Tf
.5299 0 TD
-.0217 Tc
[(9)-5.5(0)-166.8(mmH)-6.4(g\);)-305.2(d).2(ia)-6.7(st)-5.6(oli)-5.7(c)-300.4(hyp)-5.5(ot)-5.6(ens)-5.3(i).1(on)-305(\()]TJ
/F8 1 Tf
13.518 0 TD
0 Tc
(<)Tj
/F5 1 Tf
.5299 0 TD
-.0198 Tc
[(60)-164.9(mmH)-4.5(g\);)]TJ
-19.8652 -1.1116 TD
-.0216 Tc
[(sy)-5.4(sto)-5.4(l).2(i)-5.5(c)-317.6(bl)-5.6(ood)-322.2(pr)-5.4(es)-5.2(sur)-5.4(e)-317.6(i)-5.5(n).3(cr)-5.4(eas)-5.2(e)-317.6(o)-5.4(f)]TJ
/F8 1 Tf
13.7715 0 TD
0 Tc
()Tj
/F5 1 Tf
.5357 0 TD
-.0206 Tc
[(20)-165.7(m)-5.6(m).1(Hg)-321.2(compared)-315.4(w)-5.3(ith)]TJ
-14.3071 -1.1174 TD
.0118 Tc
[(b)4.9(a)-2(seli)4.8(ne;)-432.9(d)-.8(i)4.8(a)-2(s)5.1(t)-.9(o)4.9(lic)-428.2(blo)4.9(o)-.8(d)-427(press)5.1(ure)-428.2(increas)5.1(e)-434(of)]TJ
/F8 1 Tf
19.727 0 TD
0 Tc
()Tj
/F5 1 Tf
.5644 0 TD
.0104 Tc
[(10)-163.5(mmHg)]TJ
-20.2914 -1.1116 TD
.0096 Tc
[(compared)-521.4(with)-515.6(base)-4.2(line)]TJ
10.2638 0 TD
.5254 Tc
[(;r)518.6(e)511.6(s)513(t)518.4(i)512.7(n)518.5(g).2(h)512.8(e)511.6(a)517.4(r)512.8(tr)518.6(a)511.6(t)518.4(e)]TJ
/F8 1 Tf
8.7663 0 TD
0 Tc
(<)Tj
/F5 1 Tf
.5587 0 TD
.0126 Tc
[(50)-161.3(bp)5.7(m)-513.9(\()0(o)5.7(r)]TJ
/F8 1 Tf
-19.5888 -1.1116 TD
0 Tc
(<)Tj
/F5 1 Tf
.5587 0 TD
.0131 Tc
[(45)-160.8(bpm)-334.8(in)-333.6(at)6.1(hl)6.1(et)6.1(es\))6.3(;)-339.5(g)6.2(r).5(ad)6.2(e)-340.5(3)6.2(,)-335.9(4).5(,)-335.9(o).5(r)-333.5(5)-339.3(AE)5(s)-339.1(\()6.3(mo)6.2(ni)6.1(tor)6.3(e)-.7(d)-333.6(v).5(i)6.1(a)]TJ
-.5587 -1.1116 TD
.0072 Tc
[(th)-5.4(e)-605.6(9).3(1)-5.4(-).4(i)-5.5(t).2(e)-6.6(m)-605.6(sy)-5.4(mp)-5.4(to)-5.4(m)-599.9(m)-6.6(on)-5.4(it)-5.5(o)-5.4(r).4(i)-5.5(n).3(g)-604.4(f)-5.4(or)-5.4(m\))-5.4(;)-604.6(o).3(r)-604.4(p).3(a)-6.6(r)-5.4(ti)-5.5(ci)-5.5(pa)-6.6(nt)]TJ
0 -1.1174 TD
.0119 Tc
[(elect)4.9(e)-1.9(d)-352.1(t)4.9(o)-352.1(w)4.2(it)4.9(hd)5(raw)-347.2(f)-.7(r)5.1(o)-.7(m)-347.5(t)-.8(h)5(e)-353.2(s)5.2(t)-.8(ud)5(y)-352.1(c)3.9(it)4.9(in)5(g)-352.1(A)-1.6(Es.)-348.6(S)5.2(tatis)5.2(ti)4.9(cal)]TJ
0 -1.1116 TD
[(analy)5.1(s)-.4(es)-357.5(were)-358.9(p)5.1(e)-1.8(rf)5.2(or)5.2(med)-357.7(u)-.6(si)5(ng)-357.7(SP)5.3(SS)-357.6(v.2)5.1(0)-363.5(s)5.3(o)-.6(f)5.2(t)-.7(ware)-358.9(\()5.2(I)-.6(BM)]TJ
T*
.0098 Tc
[(Corp.,)-333.5(A)-3.7(r)3(m)-4(o)2.9(nk,)-333.5(N)-3.7(Y\).)]TJ
/F3 1 Tf
8.9663 0 0 8.9663 310.8472 100.4031 Tm
0 Tc
(Results)Tj
/F14 1 Tf
0 -1.8336 TD
[(Participant)-334.4(characteristics)]TJ
/F5 1 Tf
9.843 0 0 9.843 320.8251 67.5212 Tm
.0246 Tc
[(Baselin)-5.3(e)-651.5(d).5(e)-6.5(m)-.8(ograph)-5.3(ic)-651.5(pa)-6.5(rameter)-5.3(s)-650.2(ar)-5.3(e)-651.5(d).5(e)-6.5(s).7(crib)-5.3(ed)-650.4(in)]TJ
-1.0137 -1.1116 TD
0 Tc
[(Ta)18.5(bl)20.7(e)-307.5(1)0(.)-298.3(M)0(e)18.8(a)0(n)-302.9(s)0(y)21(s)0(t)20.9(o)0(l)14.9(i)0(c)-297.2(a)0(n)19.7(d)-312.1(di)20.7(as)19.9(to)20.7(li)20.6(c)-313.3(b)0(l)20.7(o)0(o)20.8(d)-312.1(pr)20.9(es)19.9(su)21(re)-302.8(re)19.7(ad)19.7(in)20.7(gs)]TJ
/F11 1 Tf
8.9663 0 0 8.9663 59.7543 749.7069 Tm
[(SAFETY)-336.6(OF)-337.5(A)-331.6(CARDIOVASCULAR)-343.2(HEALTH)-333.8(SUPPLEMENT)-24926.7(251)]TJ
ET
endstream
endobj
48 0 obj
<>stream
h\S{LSg{*d\xU(*
ZʢMiTh:APcS^NgB pRG\t!Fe?4u3_r8wsrG
AY2L9 >.DdI1_h}A%'AM@]RHH9V[kH!.9h&d&
i&[YйNsCXd5e6i6ᅂCf{fK*N XAp
&s^
Y*3i4f,]džd1-f̿3tIL#8 R
"PH#ed&e6ȎȾsFeCE$VUC`nJݯ'JKw39
h\ʢ1˱
@e(kc|uHf 0?}OxWϰdlY[T*((i<>+xD`H0uPg<
7]Jwm&/>h5
lsc]MMU.
d1\dhsYۻz7SAX} b6Pv+<+Db^ GBC&SAXȎQe1m2Q(~C|ݴJ@Ӄ3OqWUc({/Yg#p S`+M7CKk`h@s*1Ӯ%Il@
?Fs97>xNr*f͌fKG>+JQ{,S>9.s84DRܻJbؘlyw$D"N˗HN"Ҽ&/:M( l*,7k(G4rPILm̿K:.q<*<m)~H.fRz=5ˊy2]'N`Z ӢN{lWlll^%PY5M8,L
s''yMr{n՟yu{8sn/tѷO>]/]7f
SE|qݺW;j2B#-%TFP;~Za5UUU,(hW *͐:
f` eh
endstream
endobj
51 0 obj
<>stream
/GS1 gs
BT
/F5 1 Tf
9.843 0 0 9.843 62.022 450.3117 Tm
0 0 0 rg
.0122 Tc
0 Tw
[(at)-461.3(baseli)5.2(ne)-462.4(were)-462.4(co)5.3(nsi)5.2(s)-.2(t)5.2(e)-1.6(nt)]TJ
12.0839 0 TD
.0116 Tc
[(with)-461.8(JNC)-468.6(7)-461.8(clas)4.9(si)4.6(cati)4.6(o)-1(n)-461.8(o)-1(f)]TJ
-12.0839 -1.1116 TD
.0126 Tc
[(pr)5.8(eh)5.7(yp)5.7(ert)5.6(e)-1.2(n)5.7(s).2(i)5.6(on.)-227(Flo)5.7(w)-231.3(of)-230.4(the)-231.6(s)5.9(tud)5.7(y)-230.4(is)-230.2(descr)5.8(i)-.1(b)5.7(e)-1.2(d)-230.4(i)-.1(n)-230.4(F).1(i)5.6(g)0(u)5.7(r)0(e)-231.6(1)0(;)]TJ
T*
.0123 Tc
[(19)-259.5(p)5.4(a)-1.5(r)5.5(ticip)5.4(an)5.4(ts)-259.3(co)5.4(mp)5.4(leted)-265.3(t)5.3(he)]TJ
12.4179 0 TD
[(s)5.5(t)-.5(ud)5.3(y,)-256.2(9)-265.4(e)4.2(lect)5.2(ed)-259.6(to)-259.6(wit)5.2(hdr)5.4(aw,)]TJ
-12.4179 -1.1174 TD
.0201 Tc
[(1)-372.7(w)-4.9(as)-372.5(w)-4.9(ithdraw)-4.9(n)-372.7(b)1.7(y)-372.7(t)-4.2(he)-373.8(investigators,)-375(and)-372.7(1)-372.7(w)-4.9(as)-372.5(lost)-372.8(to)]TJ
0 -1.1116 TD
.0185 Tc
[(fo)-5.6(llo)-5.6(w-u)-5.6(p).1(.)]TJ
/F14 1 Tf
8.9663 0 0 8.9663 62.022 379.7857 Tm
0 Tc
[(Primary)-333.5(measures)]TJ
/F5 1 Tf
9.843 0 0 9.843 72 363.3448 Tm
[(Signicant)-284.1(changes)-287.5(in)-278.8(primary)-286.6(measures)-289.6(were)-284(infrequent,)]TJ
-1.0137 -1.1116 TD
[(both)-269.5(from)-264.7(baseline)-271.6(to)-267.3(the)-269.5(3-month)-262.5(visit)-270.6(and)-269.4(from)-264.7(baseline)-271.5(to)]TJ
0 -1.1174 TD
[(the)-281.1(6-month)-279.7(visit)-282.2(\(Table)-280.9(2\).)-282.1(However,)-285.9(changes)-281.7(in)-278.8(potassium)]TJ
0 -1.1116 TD
[(levels)-348.8(were)-353.2(signicant)-347.4(both)-350.1(from)-345.4(baseline)-352.2(to)-347.9(3)-346.7(months)-347.6(and)]TJ
T*
[(from)-587.3(baseline)-594.1(to)-589.8(6)-588.6(months)-589.5(\()]TJ
/F6 1 Tf
12.9133 0 TD
(p)Tj
/F8 1 Tf
.6624 0 TD
(<)Tj
/F5 1 Tf
.72 0 TD
[(0.05\).)-593(Changes)-586.9(in)-589.8(NT-)]TJ
-14.2956 -1.1174 TD
[(proBNP,)-582(sodium,)-581.4(calcium,)-580.6(magnesium)-8.9(,)-579.4(AST,)-578.9(ALT,)-580.2(and)]TJ
25.504 42.3281 TD
[(eGFR)-329.9(were)-324.4(nonsig)-6.5(nicant.)-324.6(Primary)-326.8(outcome)-328.2(measures)-329.9(plus)]TJ
0 -1.1174 TD
[(additional)-244.3(safety)-245(and)-240.6(tolerability)-246.7(criteria)-248.8(were)-243.7(also)-241.6(examined)]TJ
0 -1.1116 TD
[(as)-337.2(a)-336.3(composite)-336.1(\(Table)-332.8(3\).)]TJ
/F14 1 Tf
8.9663 0 0 8.9663 313.0582 681.2786 Tm
[(Adverse)-334.8(events)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 664.8376 Tm
[(No)-360.2(serious)-359.9(AEs)-356.5(were)-358.9(reported)-356.8(by)-359.3(any)-355.8(participant)-361.7(during)]TJ
-1.0137 -1.1116 TD
[(the)-355.9(study.)-348.7(Nine)-357.9(participants)-356.8(\(30%\))-352.1(elected)-352.4(to)-353.7(withdraw)-351.8(be-)]TJ
0 -1.1174 TD
[(fore)-431.7(completion)-429.7(citing)-422.9(nonserious)-432.4(AEs)-425.6(as)-429.4(the)-425.1(reason)-429.2(\(Ta-)]TJ
0 -1.1116 TD
[(ble)-430.8(4\).)-420.3(AEs)-425.6(reported)-431.7(by)-422.7(10%)-424.8(or)-422.6(more)-427.2(of)-422.6(the)-425.1(entire)-429.6(study)]TJ
T*
[(population)-456.1(included)-454.9(the)-453.8(following:)-455.9(lightheadedness)-453.2(\()]TJ
/F6 1 Tf
22.1576 0 TD
(n)Tj
/F8 1 Tf
.6681 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
(9,)Tj
-23.5457 -1.1174 TD
[(30%\),)-400.5(nasal)-399.4(congestion)-393.5(\()]TJ
/F6 1 Tf
10.3444 0 TD
(n)Tj
/F8 1 Tf
.6681 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
[(6,)-396.2(20%\),)-394.8(feeling)-396.2(tired/fatigued)]TJ
-11.7325 -1.1116 TD
(\()Tj
/F6 1 Tf
.3341 0 TD
(n)Tj
/F8 1 Tf
.6681 0 TD
(=)Tj
/F5 1 Tf
.72 0 TD
[(6,)-332.8(20%\),)-331.4(and)-338.5(headache)-337.2(\()]TJ
/F6 1 Tf
10.0219 0 TD
(n)Tj
/F8 1 Tf
.6681 0 TD
(=)Tj
/F5 1 Tf
.7142 0 TD
[(3,)-332.8(10%\).)]TJ
/F14 1 Tf
8.9663 0 0 8.9663 313.0582 577.1337 Tm
[(Exploratory)-335.5(measures)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 560.6927 Tm
[(Signicant)-428.1(chang)-7.8(es)-423.6(in)-428.5(exploratory)-429.3(measures)-433.6(were)-428(more)]TJ
-1.0137 -1.1174 TD
[(frequent)-379.8(than)-374.3(in)-370.9(primary)-373(measures)-376(\(Table)-378.8(5\).)-368.5(Decreases)-379(in)]TJ
0 -1.1116 TD
[(systoli)-7.7(c)-296(and)-292.4(diastolic)-300.6(blood)-299.4(pressure)-298.7(were)-295.6(highly)-300.6(signicant)]TJ
T*
[(at)-493.1(3)-490.7(and)-488.3(6)-490.7(months)-491.6(compared)-491.6(with)-489.3(baseline)-496.2(\()]TJ
/F6 1 Tf
19.5772 0 TD
(p)Tj
/F8 1 Tf
.6624 0 TD
(<)Tj
/F5 1 Tf
.72 0 TD
(0.0001\).)Tj
-20.9596 -1.1116 TD
[(Several)-385.5(blood)-374.3(measures)-381.7(also)-374.1(chang)-7.8(ed)-372(signicantly,)-382(includ-)]TJ
0 -1.1174 TD
[(ing)-533.3(cystatin)-529.7(C,)-529.7(RBC)-530.5(count,)-528.6(hemoglobin,)-529.7(and)-528.6(hematocrit)]TJ
0 -1.1116 TD
(\()Tj
/F6 1 Tf
.5011 0 TD
(p)Tj
/F8 1 Tf
.6681 0 TD
(<)Tj
/F5 1 Tf
.72 0 TD
[(0.05\).)-368.3(However,)-366.5(mean)-370.8(values)-366(for)-366.1(these)-370.6(biomarkers)-365.8(re-)]TJ
-1.8892 -1.1116 TD
[(mained)-246.4(within)-238.3(normal)-245.3(laboratory)-238.2(reference)-246(ranges)-244.9(at)-239.6(all)-240.9(time)]TJ
0 -1.1174 TD
[(points.)-269.3(There)-273.9(were)-266.8(no)-272.9(signicant)-266.8(changes)-270.2(in)-273(high-sensitivity)]TJ
0 -1.1116 TD
[(cardiac)-634.5(troponin-I,)-636.7(endothelin,)-627.7(cholesterol,)-635.5(inammatory)]TJ
T*
[(markers,)-423.4(white)-416.7(blood)-420.3(cell)-415.9(and)-419.2(platelet)-421.8(counts,)-414.3(sleep)-422.5(ques-)]TJ
0 -1.1174 TD
[(tionnaire)-340.9(total)-335.4(score,)-333.6(or)-336.2(heart)-336.2(rate.)]TJ
/F14 1 Tf
8.9663 0 0 8.9663 313.0582 418.1668 Tm
[(Study)-338.6(supplement)-331.7(adherence)]TJ
/F5 1 Tf
9.843 0 0 9.843 323.0361 401.7259 Tm
[(A)-416.7(pill)-419.5(count)-415.7(of)-416.9(unused)-416.5(study)-420.1(supplement)-417.8(indicated)-422.7(that)]TJ
-1.0137 -1.1116 TD
[(adherence)-344(throughout)-333.8(the)-332.9(study)-333.7(was)-333.4(90.9%)]TJ
/F8 1 Tf
17.8378 0 TD
()Tj
/F5 1 Tf
.72 0 TD
(11.6%.)Tj
/F3 1 Tf
8.9663 0 0 8.9663 313.0582 368.844 Tm
(Discussion)Tj
/F5 1 Tf
9.843 0 0 9.843 323.0361 352.403 Tm
[(This)-420.2(trial)-421.7(rigorously)-420(collected)-418.1(long-term)-421.4(safety)-423.5(and)-419.2(tol-)]TJ
-1.0137 -1.1174 TD
[(erability)-254.6(data)-254.5(on)-249.9(a)-249.9(dietary)-252.2(supplement)-250.8(using)-247.3(a)-244.2(s)0(e)19.9(m)0(i)19.5(p)0(r)20.9(a)0(g)19.7(m)0(a)18.4(t)0(i)20.6(c)]TJ
0 -1.1116 TD
[(mo)19.6(de)13.9(l.)-240.8(Th)19.6(e)-249.9(s)0(u)21(p)0(p)20.8(l)0(e)19.6(m)0(e)18.4(n)0(t)-244.2(e)0(v)19.7(a)0(l)19.5(u)0(a)19.7(t)0(e)19.5(d)-248.8(ha)13.9(s)-248.6(b)0(e)19.7(e)0(n)-239.5(s)0(o)15.3(l)0(d)-238.5(i)0(n)-238.5(t)0(h)15(e)-249.9(Un)20(it)20.6(ed)]TJ
T*
[(St)15.1(at)19.5(es)-291.2(fo)15.1(r)-300.6(2)0(5)-295.9(y)0(e)19.7(a)0(r)19.7(s)-306.2(an)19.7(d)-306.4(i)0(s)-290.1(r)0(e)19.7(c)0(o)13.9(m)15(me)18.4(nd)15.1(ed)-291.3(by)-295.9(na)19.7(tu)20.7(ro)20.9(pa)19.7(th)20.7(ic)-297.2(an)19.7(d)]TJ
0 -1.1174 TD
[(co)13.9(m)15(p)0(l)14.9(e)0(m)18.5(e)0(n)19.7(t)0(a)19.6(r)0(y)-244.1(m)0(e)18.4(d)0(i)20.7(c)0(i)19.6(n)0(e)-245.3(p)0(r)20.9(o)0(v)20.8(i)0(d)20.7(e)0(r)19.7(s)-254.3(fo)20.9(r)-254.5(c)0(a)18.5(r)0(d)20.9(i)0(o)20.7(v)0(a)13.9(s)0(c)19.9(u)0(l)20.7(a)0(r)-245.2(health.)]TJ
ET
62.022 709.512 239.131 .22681 re
f
62.022 487.616 239.131 .28345 re
f
62.022 690.746 239.131 .22675 re
f
BT
/F13 1 Tf
9.845 0 0 9.845 103.8047 725.1588 Tm
(Table)Tj
/F5 1 Tf
3.0002 0 TD
(1.)Tj
/F13 1 Tf
1.2496 0 TD
[(Baseline)-332.4(Characteristics)]TJ
-2.1249 -1.0135 TD
[(of)-331.2(the)-338.1(Study)-333.8(Population)]TJ
/F6 1 Tf
9.6456 -1.8427 TD
(Mean)Tj
/F8 1 Tf
2.4531 0 TD
()Tj
/F6 1 Tf
.7141 0 TD
[(SD)-336.8(or)]TJ
/F5 1 Tf
2.7699 0 TD
(n)Tj
/F6 1 Tf
.835 0 TD
(\(%\))Tj
/F5 1 Tf
-22.7866 -1.9061 TD
[(Age)-333.2(\(years\))-13184.7(51.0)]TJ
/F8 1 Tf
19.8785 0 TD
()Tj
/F5 1 Tf
.7141 0 TD
(10.4)Tj
-20.5926 -1.3129 TD
(Gender)Tj
1.002 -1.0135 TD
[(Male)-15215.6(17)-330.2(\(56.7\))]TJ
T*
[(Female)-14320.6(13)-330.2(\(43.3\))]TJ
-1.002 -1.313 TD
(Race)Tj
1.002 -1.0135 TD
[(White)-14819.6(24)-330.2(\(80.0\))]TJ
T*
[(More)-334.2(than)-333.5(1)-335(race)-10706.9(3)-329.2(\(10.0\))]TJ
T*
[(Asian)-15445.6(2)-329.2(\(6.7\))]TJ
0 -1.0077 TD
[(American)-336.1(Indian)-335.5(or)-330.2(Alaska)-337.3(Native)-3637.3(1)-329.2(\(3.3\))]TJ
-1.002 -1.3187 TD
(Ethnicity)Tj
1.002 -1.0135 TD
[(Not)-332.2(Hispanic)-339.5(or)-330.2(Latino)-7759.6(25)-330.2(\(83.3\))]TJ
0 -1.0077 TD
[(Hispanic)-333.7(or)-336(Latino)-10091.8(5)-329.2(\(16.7\))]TJ
-1.002 -1.3187 TD
[(Body)-333.2(mass)-334.2(index)-334.5(\(kg/m)]TJ
7.3837 0 0 6.5625 158.3999 551.1117 Tm
(2)Tj
9.845 0 0 9.845 162.1417 546.7463 Tm
[(\))-7705.9(28.1)]TJ
/F8 1 Tf
9.9565 0 TD
()Tj
/F5 1 Tf
.7198 0 TD
(5.4)Tj
-20.8459 -1.0077 TD
[(Resting)-337.5(heart)-335.7(rate)-334.7(\(bpm\))-8177.5(65.8)]TJ
/F8 1 Tf
20.1261 0 TD
()Tj
/F5 1 Tf
.7198 0 TD
(8.2)Tj
-20.8459 -1.0135 TD
[(Blood)-334.4(pressure)]TJ
1.002 -1.0135 TD
[(Systolic)-331.7(\(mmHg\))-9700.7(133.7)]TJ
/F8 1 Tf
19.1241 0 TD
()Tj
/F5 1 Tf
.7198 0 TD
(10.5)Tj
-19.8439 -1.0135 TD
[(Diastolic)-335.1(\(mmHg\))-9804.4(80.6)]TJ
/F8 1 Tf
19.1241 0 TD
()Tj
/F5 1 Tf
.7198 0 TD
(7.5)Tj
-20.8459 -1.313 TD
[(Taking)-336.7(antihypertensive)-337.8(medication)-4167(6)-329.2(\(20\))]TJ
8.7511 0 0 8.7511 70.0157 475.8235 Tm
[(bpm,)-327.1(beats)-337(per)-333.1(minute.)]TJ
ET
q
1 i
191.622 284.428 m
552.189 284.428 l
552.189 56.92 l
191.622 56.92 l
W n
q
360.926 0 0 227.509 191.622 56.92 cm
/Im1 Do
Q
Q
BT
/F12 1 Tf
9.845 0 0 9.845 62.022 177.5621 Tm
[(FIG.)-336.7(1.)]TJ
/F5 1 Tf
4.1174 0 TD
[(Study)-333.2(ow)]TJ
-4.1174 -1.0135 TD
[(diagram.)-336.5(AEs,)-336.4(adverse)]TJ
0 -1.0077 TD
(events.)Tj
/F11 1 Tf
8.9663 0 0 8.9663 62.022 749.6502 Tm
(252)Tj
48.2817 0 TD
[(RYAN)-335.1(ET)-338.7(AL.)]TJ
ET
endstream
endobj
53 0 obj
<>stream
Adobe d C
s !1AQa"q2B#R3b$r%C4Scs5D'6Tdt&
EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz ? ^m6iK{{b7P ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??o ??Gߙ,m/ @F;_6q<}cL5
JB{ѫ֧IQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge G?e OU yFZ>oT~c ˑ_i dQ .Ge=c:Edi-mhаt?"5[\=uqu)ܬ()T͛6lٳf͛6lٳf͛6lٳf͛6lٳf͛8mԇXmpnYf創ݲxԃF}srє9^5=ZcĨx4 ֞9|4k^NvzeÒ0e=
G29hhy0'p
rĨiFЍLj囖nYf囖y7v m6qO ZG ^ol oq)=4 FSЫ
1f͛ 5텕77qE'WxZJYĞ'c|â,v.UvuV7wpN6w(qGFVVF- ڭ6Q*ANꞤTLI2ִk"+S9VH㚾2
i'@^ePZ\F HЁVs]ʰZF\L抑ƥ
4djv>4D^֬ki֓kuwQ`ޕT"zte6YݥE@Z8 ND/Rw3bw6a
VVX2'bUyRI _|]95;R
6FĐ3T, =8yKQvM?[um#7ͅi cW +4 m %7D˝/6lٳf͛6lٳf͛6lٳf͛6lٳf͛6l(ysAAA^K/_cS73z7 |ᦏMw,?j y%fu]?Mk:9"/Dd7+UgqZ FHPu7Knxrho/=[[0[MXY\_cڝ${Rz&Ui%rKqOg|խ
NoDZH[?yN|qqvlpO i,R{6g^R
G]8殣
Ŗ~ޟӥƦk5Y^)*!J郣˺Ir7ii_rrb{F?6Eig5w4&GKia2z*t˞զ?4 3#6t&ҋk7
j_*>~*ŭ 9KoHxEX*.{PmCk3ȳy}^Iѯ&}(W
copOHĀ
k/,>q4km*I5x.^Fy洸V2 UUKǷj5֗Z4ٖ$$dg4` :soMW_?.tۏ2i?K?3N4k{Qʧ챨5+?j~tD7wJm˓]YXD~xO6>`͚;Qɦ$։(k/D)xd"IT2W49/u2OFm5M?
:z<
.G3ͅYɌqךgO,6wVn%F3:l
텒?-IoZ<
U4ש]yu GC5tcID'>!OtO-D֧o/kVVHZgD65_|yJU4dZ&k$EEKVs~aJoEv>gֵY7ݳW+`,-!Ugc|7 0|۠iZ6.goXm-qYU] GM~ 7W xGom{&j0E&aфw># L?T 5A1TG
ß/0^VFuk5i/hW&YF5 M^W Lf͛6lٳf͛6lٳf͛6lٳf͛6lٳf͜N>si oW7/.