Browsing by Author Dalton, JP

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Issue DateTitleAuthor(s)
29-Nov-2007Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compoundsSkinner-Adams, TS; Lowther, J; Teuscher, F; Stack, CM; Grembecka, J; Mucha, A; Kafarski, P; Trenholme, KR; Dalton, JP; Gardiner, DL
1-Jan-2014Identification of potent and selective inhibitors of the plasmodium falciparum M18 aspartyl aminopeptidase (PfM18AAP) of human malaria via high-throughput screeningSpicer, T; Fernandez-Vega, V; Chase, P; Scampavia, L; To, J; Dalton, JP; Da Silva, FL; Skinner-Adams, TS; Gardiner, DL; Trenholme, KR; Brown, CL; Ghosh, P; Porubsky, P; Wang, JL; Whipple, DA; Schoenen, FJ; Hodder, P
1-Jan-2017The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophagesAlvarado, R; To, J; Lund, ME; Pinar, A; Mansell, A; Robinson, MW; O'Brien, BA; Dalton, JP; Donnelly, S
1-Dec-2017Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepaticaRuiz-Campillo, MT; Molina-Hernandez, V; Escamilla, A; Stevenson, M; Perez, J; Martinez-Moreno, A; Donnelly, S; Dalton, JP; Cwiklinski, K
25-May-2009Immunological interactions between 2 common pathogens, Th1-inducing Protozoan Toxoplasma gondii and the Th2-inducing helminth fasciola hepaticaMiller, CMD; Smith, NC; Ikin, RJ; Boulter, NR; Dalton, JP; Donnelly, S
1-Aug-2013Immunomodulatory molecules of Fasciola hepatica: Candidates for both vaccine and immunotherapeutic developmentDalton, JP; Robinson, MW; Mulcahy, G; O'Neill, SM; Donnelly, S
19-May-2009The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine proteaseLowther, J; Robinson, MW; Donnelly, SM; Xu, W; Stack, CM; Matthews, JM; Dalton, JP
1-Jan-2015Induction of protective immune responses against Schistosomiasis haematobium in hamsters and mice using cysteine peptidase-based vaccineTallima, H; Dalton, JP; El Ridi, RE
1-Jan-2014Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidasesEl Ridi, R; Tallima, H; Dalton, JP; Donnelly, S
1-Apr-2018Infection by the helminth parasite fasciola hepatica requires rapid regulation of metabolic, virulence, and invasive factors to adjust to its mammalian hostCwiklinski, K; Jewhurst, H; McVeigh, P; Barbour, T; Maule, AG; Tort, J; O'Neill, SM; Robinson, MW; Donnelly, S; Dalton, JP
8-Dec-2009An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: Proteins associated with invasion and infection of the mammalian hostRobinson, MW; Menon, R; Donnelly, SM; Dalton, JP; Ranganathan, S
Jan-2006Isolation and characterisation of cathepsin L1 protease from Fasciola hepatica excretory-secretory products for serodiagnosis of human fasciolosisO'Neill, S; Mulcahy, G; Dalton, JP; Adley, CC
1-Mar-2012Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactorDalton, JP; Demanga, CG; Reiling, SJ; Wunderlich, J; Eng, JWL; Rohrbach, P
1-May-2004Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicumMcCarthy, E; Stack, C; Donnelly, SM; Doyle, S; Mann, VH; Brindley, PJ; Stewart, M; Day, TA; Maule, AG; Dalton, JP
16-Jun-2009The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: Importance of active site metal ions in the binding of substrates and inhibitorsMaric, S; Donnelly, SM; Robinson, MW; Skinner-Adams, T; Trenholme, KR; Gardiner, DL; Dalton, JP; Stack, CM; Lowther, J
19-Oct-2007The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparumTeuscher, F; Lowther, J; Skinner-Adams, TS; Spielmann, T; Dixon, MWA; Stack, CM; Donnelly, S; Mucha, A; Kafarski, P; Vassiliou, S; Gardiner, DL; Dalton, JP; Trenholme, KR
1-Jun-2007The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A Leu<sup>-12</sup> to Pro<sup>-12</sup> replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removalStack, CM; Donnelly, S; Lowther, J; Xu, W; Collins, PR; Brinen, LS; Dalton, JP
1-Jun-2012The malaria digestive vacuoleWunderlich, J; Rohrbach, P; Dalton, JP
23-Aug-2012Mechanisms of Immune Modulation by Fasciola hepatica: Importance for Vaccine Development and for Novel ImmunotherapeuticsRobinson, MW; Dalton, JP; O'Neill, SM; Donnelly, SM
22-Aug-1997A method for the isolation of schistosome eggs and miracidia free of contaminating host tissuesDalton, JP; Day, SR; Drew, AC; Brindley, PJ