Browsing by Author Lowther, J

Showing results 1 to 12 of 12
Issue DateTitleAuthor(s)
25-Jun-2010Aminopeptidases of malaria parasites: New targets for chemotherapyTrenholme, KR; Brown, CL; Skinner-Adams, TS; Stack, C; Lowther, J; To, J; Robinson, MW; Donnelly, SM; Dalton, JP; Gardiner, DL
9-Feb-2010Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidasesMcGowan, S; Oellig, CA; Birru, WA; Caradoc-Davies, TT; Stack, CM; Lowther, J; Skinner-Adams, T; Mucha, A; Kafarski, P; Grembecka, J; Trenholme, KR; Buckle, AM; Gardiner, DL; Dalton, JP; Whisstock, JC
16-Jun-2009The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: Importance of active site metal ions in the binding of substrates and inhibitorsMaric, S; Donnelly, SM; Robinson, MW; Skinner-Adams, T; Trenholme, KR; Gardiner, DL; Dalton, JP; Stack, CM; Lowther, J
19-May-2009The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine proteaseLowther, J; Robinson, MW; Donnelly, SM; Xu, W; Stack, CM; Matthews, JM; Dalton, JP
24-Feb-2009Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseMcGowan, S; Porter, CJ; Lowther, J; Stack, CM; Golding, SJ; Skinner-Adams, TS; Trenholme, KR; Teuscher, F; Donnelly, SM; Grembecka, J; Mucha, A; Kafarski, P; Degori, R; Buckle, AM; Gardiner, DL; Whisstock, JC; Dalton, JP
1-Jun-2008Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: Expansion of a repertoire of virulence-associated factorsRobinson, MW; Tort, JF; Lowther, J; Donnelly, SM; Wong, E; Xu, W; Stack, CM; Padula, M; Herbert, B; Dalton, JP
11-Apr-2008Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepaticaStack, CM; Caffrey, CR; Donnelly, SM; Seshaadri, A; Lowther, J; Tort, JF; Collins, PR; Robinson, MW; Xu, W; McKerrow, JH; Craik, CS; Geiger, SR; Marion, R; Brinen, LS; Dalton, JP
29-Nov-2007Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compoundsSkinner-Adams, TS; Lowther, J; Teuscher, F; Stack, CM; Grembecka, J; Mucha, A; Kafarski, P; Trenholme, KR; Dalton, JP; Gardiner, DL
19-Oct-2007The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparumTeuscher, F; Lowther, J; Skinner-Adams, TS; Spielmann, T; Dixon, MWA; Stack, CM; Donnelly, S; Mucha, A; Kafarski, P; Vassiliou, S; Gardiner, DL; Dalton, JP; Trenholme, KR
4-Sep-2007Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteasesKanaji, S; Tanaka, Y; Sakata, Y; Takeshita, K; Arima, K; Ohta, S; Hansell, EJ; Caffrey, C; Mottram, JC; Lowther, J; Donnelly, S; Stack, C; Kadowaki, T; Yamamoto, K; McKerrow, JH; Dalton, JP; Coombs, GH; Izuhara, K
1-Jun-2007The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A Leu<sup>-12</sup> to Pro<sup>-12</sup> replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removalStack, CM; Donnelly, S; Lowther, J; Xu, W; Collins, PR; Brinen, LS; Dalton, JP
19-Jan-2007Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: A protease involved in amino acid regulation with potential for antimalarial drug developmentStack, CM; Lowther, J; Cunningham, E; Donnelly, S; Gardiner, DL; Trenholme, KR; Skinner-Adams, TS; Teuscher, F; Grembecka, J; Mucha, A; Kafarski, P; Lua, L; Bell, A; Dalton, JP