Browsing byAuthorRawling, T

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Issue DateTitleAuthor(s)
2023-12-21Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids.MacDermott-Opeskin, H; Clarke, C; Wu, X; Roseblade, A; York, E; Pacchini, E; Roy, R; Cranfield, C; Gale, PA; O'Mara, ML; Murray, M; Rawling, T
2023-09An update on inflammation in uveal melanoma.Liau, S; Wang, JZ; Zagarella, E; Paulus, P; Dang, NHQH; Rawling, T; Murray, M; Zhou, F
2023-08-30Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML:a randomized, placebo-controlled study by the ALLG.Loo, S; Roberts, AW; Anstee, NS; Kennedy, GA; He, SZ-X; Schwarer, AP; Enjeti, AK; D'Rozario, J; Marlton, P; Bilmon, I; Taper, JM; Cull, G; Tiley, C; Verner, E; Hahn, U; Hiwase, DK; Iland, HJ; Murphy, NE; Ramanathan, S; Reynolds, J; Ong, DM; Tiong, IS; Wall, M; Murray, M; Rawling, T; Leadbetter, J; Rowley, L; Latimer, M; Yuen, SLS; Ting, SB; Fong, CY; Morris, KL; Bajel, A; Seymour, JF; Levis, MJ; Wei, AH
2023-08-02Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2.Gallagher, CI; Frangos, ZJ; Sheipouri, D; Shimmon, S; Duman, M-N; Jayakumar, S; Cioffi, CL; Rawling, T; Vandenberg, RJ
2023-07-31Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells.York, E; McNaughton, DA; Duman, M-N; Gale, PA; Rawling, T
2023-07-14Aromatic long chain cations of amphiphilic ionic liquids permeabilise the inner mitochondrial membrane and induce mitochondrial dysfunction at cytotoxic concentrationsDuman, MN; Angeloski, A; Johnson, MS; Rawling, T
2023-01-15Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids.Rahman, MK; Umashankar, B; Choucair, H; Pazderka, C; Bourget, K; Chen, Y; Dunstan, CR; Rawling, T; Murray, M
2022-09Peripheral administration of selective GlyT2 inhibitor, oleoyl-D-lysine, reverses chronic neuropathic pain but not acute or inflammatory pain in male miceWilson, BS; Peiser-Oliver, J; Gillis, A; Evans, S; Alamein, C; Mostyn, SN; Shimmon, S; Rawling, T; Christie, MJ; Vandenberg, RJ; Mohammadi, SA
2022-08-19Structure-Activity Relationship and Mechanistic Studies of Bisaryl Urea Anticancer Agents Indicate Mitochondrial Uncoupling by a Fatty Acid-Activated Mechanism.York, E; McNaughton, DA; Roseblade, A; Cranfield, CG; Gale, PA; Rawling, T
2022-02-01The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism.Choucair, H; Rahman, MK; Umashankar, B; Al-Zubaidi, Y; Bourget, K; Chen, Y; Dunstan, C; Rawling, T; Murray, M
2021-10PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling.Al-Zubaidi, Y; Chen, Y; Khalilur Rahman, M; Umashankar, B; Choucair, H; Bourget, K; Chung, L; Qi, Y; Witting, PK; Anderson, RL; O'Neill, GM; Dunstan, CR; Rawling, T; Murray, M
2021-02-05Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite.Nair, PC; Gillani, TB; Rawling, T; Murray, M
2021-02-03Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake.Chen, S-Y; Beretta, M; Alexopoulos, SJ; Shah, DP; Olzomer, EM; Hargett, SR; Childress, ES; Salamoun, JM; Aleksovska, I; Roseblade, A; Cranfield, C; Rawling, T; Quinlan, KGR; Morris, MJ; Tucker, SP; Santos, WL; Hoehn, KL
2021-01-12The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity.Wilson, KA; Mostyn, SN; Frangos, ZJ; Shimmon, S; Rawling, T; Vandenberg, RJ; O'Mara, ML
2020-10Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors.Gallagher, CI; Sheipouri, D; Shimmon, S; Rawling, T; Vandenberg, RJ
2020-08-16Expansion of the structure-activity relationship of branched chain fatty acids: effect of unsaturation and branching group size on anticancer activity.Roy, R; Roseblade, A; Rawling, T
2020-05Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2.Mostyn, SN; Sarker, S; Muthuraman, P; Raja, A; Shimmon, S; Rawling, T; Cioffi, CL; Vandenberg, RJ
2020Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and Their Application in Drug Discovery.Pazderka, CW; Oliver, B; Murray, M; Rawling, T
2020Antiproliferative activities of tricyclic amides derived from β-caryophyllene via the Ritter reaction against MDA-MB-231 breast cancer cellsXu, X; Roseblade, A; Rawling, T; Ung, AT
2019-11-01Inhibition of Hepatic CYP2D6 by the Active N-Oxide Metabolite of SorafenibMurray, M; Gillani, TB; Rawling, T; Nair, PC