Browsing by Author Stack, CM

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Showing results 1 to 20 of 20
Issue DateTitleAuthor(s)
25-Jun-2012Anti-malaria drug development targeting the M1 alanyl and M17 leucyl aminopeptidasesThivierge, K; Mathew, RT; Nsangou, DMM; Da Silva, F; Cotton, S; Skinner-Adams, TS; Trenholme, KR; Brown, CL; Stack, CM; Gardiner, DL; Dalton, JP
18-Sep-2006Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepaticaSekiya, M; Mulcahy, G; Irwin, JA; Stack, CM; Donnelly, SM; Xu, W; Collins, P; Dalton, JP
23-Apr-2004Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: Propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cellsCollins, PR; Stack, CM; O'Neill, SM; Doyle, S; Ryan, T; Brennan, GP; Mousley, A; Stewart, M; Maule, AG; Dalton, JP; Donnelly, S
19-Jan-2007Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: A protease involved in amino acid regulation with potential for antimalarial drug developmentStack, CM; Lowther, J; Cunningham, E; Donnelly, S; Gardiner, DL; Trenholme, KR; Skinner-Adams, TS; Teuscher, F; Grembecka, J; Mucha, A; Kafarski, P; Lua, L; Bell, A; Dalton, JP
1-Mar-2017Comparative proteomic analysis of two pathogenic Tritrichomonas foetus genotypes: there is more to the proteome than meets the eyeStroud, LJ; Šlapeta, J; Padula, MP; Druery, D; Tsiotsioras, G; Coorssen, JR; Stack, CM
1-Sep-2005De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serumStack, CM; Dalton, JP; Cunneen, M; Donnelly, S
1-Nov-2008Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophagesDonnelly, S; Stack, CM; O'Neill, SM; Sayed, AA; Williams, DL; Dalton, JP
29-Jan-2010Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3Donnelly, S; O'Neill, SM; Stack, CM; Robinson, MW; Turnbull, L; Whitchurch, C; Dalton, JP
29-Nov-2007Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compoundsSkinner-Adams, TS; Lowther, J; Teuscher, F; Stack, CM; Grembecka, J; Mucha, A; Kafarski, P; Trenholme, KR; Dalton, JP; Gardiner, DL
19-May-2009The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine proteaseLowther, J; Robinson, MW; Donnelly, SM; Xu, W; Stack, CM; Matthews, JM; Dalton, JP
16-Jun-2009The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: Importance of active site metal ions in the binding of substrates and inhibitorsMaric, S; Donnelly, SM; Robinson, MW; Skinner-Adams, T; Trenholme, KR; Gardiner, DL; Dalton, JP; Stack, CM; Lowther, J
19-Oct-2007The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparumTeuscher, F; Lowther, J; Skinner-Adams, TS; Spielmann, T; Dixon, MWA; Stack, CM; Donnelly, S; Mucha, A; Kafarski, P; Vassiliou, S; Gardiner, DL; Dalton, JP; Trenholme, KR
1-Jun-2007The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: A Leu<sup>-12</sup> to Pro<sup>-12</sup> replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removalStack, CM; Donnelly, S; Lowther, J; Xu, W; Collins, PR; Brinen, LS; Dalton, JP
20-Jan-2006Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites: Target for the antimalarial activity of bestatinGardiner, DL; Trenholme, KR; Skinner-Adams, TS; Stack, CM; Dalton, JP
Jan-2007Peptidases of Trichobilharzia regenti (Schistosomatidae) and its molluscan host Radix peregra s.lat. (Lymnaeidae) Construction and screening of cDNA library from intramolluscan stages of the parasiteDoleckova, K; Kasny, M; Mikes, L; Mutapi, F; Stack, CM; Mountford, A; Horak, P
1-Oct-2016A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformabilityda Silva, FL; Dixon, MWA; Stack, CM; Teuscher, F; Taran, E; Jones, MK; Lovas, E; Tilley, L; Brown, CL; Trenholme, KR; Dalton, JP; Gardiner, DL; Skinner-Adams, TS
1-Jun-2008Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: Expansion of a repertoire of virulence-associated factorsRobinson, MW; Tort, JF; Lowther, J; Donnelly, SM; Wong, E; Xu, W; Stack, CM; Padula, M; Herbert, B; Dalton, JP
11-Apr-2008Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepaticaStack, CM; Caffrey, CR; Donnelly, SM; Seshaadri, A; Lowther, J; Tort, JF; Collins, PR; Robinson, MW; Xu, W; McKerrow, JH; Craik, CS; Geiger, SR; Marion, R; Brinen, LS; Dalton, JP
24-Feb-2009Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseMcGowan, S; Porter, CJ; Lowther, J; Stack, CM; Golding, SJ; Skinner-Adams, TS; Trenholme, KR; Teuscher, F; Donnelly, SM; Grembecka, J; Mucha, A; Kafarski, P; Degori, R; Buckle, AM; Gardiner, DL; Whisstock, JC; Dalton, JP
9-Feb-2010Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidasesMcGowan, S; Oellig, CA; Birru, WA; Caradoc-Davies, TT; Stack, CM; Lowther, J; Skinner-Adams, T; Mucha, A; Kafarski, P; Grembecka, J; Trenholme, KR; Buckle, AM; Gardiner, DL; Dalton, JP; Whisstock, JC