TY  - JOUR
AB  - © 2015 European Academy of Neurology. Background and purpose: Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. Methods: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age ? 55 years). Results: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (±8%, P < 0.001) and 34% (±10%, P < 0.001), respectively. Conclusions: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant.
AU  - Bluher, A
AU  - Devan, WJ
AU  - Holliday, EG
AU  - Nalls, M
AU  - Parolo, S
AU  - Bione, S
AU  - Giese, AK
AU  - Boncoraglio, GB
AU  - Maguire, JM
AU  - Müller-Nurasyid, M
AU  - Gieger, C
AU  - Meschia, JF
AU  - Rosand, J
AU  - Rolfs, A
AU  - Kittner, SJ
AU  - Mitchell, BD
AU  - O'Connell, JR
AU  - Cheng, YC
DA  - 2015/11/01
DO  - 10.1111/ene.12827
EP  - 1491
JO  - European Journal of Neurology
PY  - 2015/11/01
SP  - 1488
TI  - Heritability of young- and old-onset ischaemic stroke
VL  - 22
Y1  - 2015/11/01
Y2  - 2026/07/06
ER  -