TY  - JOUR
AB  - © 2017 Elsevier B.V. The aggregation of the protein amyloid-? in the brain has been associated with neurodegenerative diseases such as Alzheimer's disease. Such aggregation of amyloid-? can be induced by misregulated metal ions such as Cu2+ and Zn2+. Here we present four metal chelating compounds based on the cyclen macrocycle that each bear a pendant arm to provide additional anti-oxidant activity. The corresponding Cu2+, Zn2+ and Ni2+ complexes have been synthesized and characterized to examine the ability of the chelators to bind to the metal centres. A?40 de-aggregation by the cyclen compounds was assessed using turbidometry and the re-solubilization of the A?40 was also examined. Our results show that the cyclen compounds have the ability to effectively chelate Cu2+ and Zn2+ metal ions and thus de-aggregate A?40 that has been aggregated due to the presence of these ions. The antioxidant properties of the cyclen compounds were tested by using the DPPH scavenging assay and the results show that some of the compounds can decrease oxidative stress.
AU  - Safadi, ME
AU  - Bhadbhade, M
AU  - Shimmon, R
AU  - Baker, AT
AU  - McDonagh, AM
DA  - 2017/10/01
DO  - 10.1016/j.ica.2017.07.060
EP  - 350
JO  - Inorganica Chimica Acta
PY  - 2017/10/01
SP  - 343
TI  - Cyclen-based chelators for the inhibition of A? aggregation: Synthesis, anti-oxidant and aggregation evaluation
VL  - 467
Y1  - 2017/10/01
Y2  - 2026/07/26
ER  -