TY  - JOUR
AB  - We illustrate some of the uses of micro-computed tomography (micro-CT) to study tissue-engineered bone using a micro-CT facility for imaging and visualizing biomaterials in three dimensions (3-D). The micro-CT is capable of acquiring 3D X-ray CT images made up of 20003 voxels on specimens up to 5 cm in extent with resolutions down to 2 ?m. This allows the 3-D structure of tissue-engineered materials to be imaged across orders of magnitude in resolution. This capability is used to examine an explanted, tissue-engineered bone material based on a polycaprolactone scaffold and autologous bone marrow cells. Imaging of the tissue-engineered bone at a scale of 1 cm and resolutions of 10 ?m allows one to visualize the complex ingrowth of bone into the polymer scaffold. From a theoretical viewpoint the voxel data may also be used to calculate expected mechanical properties of the tissue-engineered implant. These observations illustrate the benefits of tomography over traditional techniques for the characterization of bone morphology and interconnectivity. As the method is nondestructive it can perform a complimentary role to current histomorphometric techniques. © 2004 Kluwer Academic Publishers.
AU  - Jones, AC
AU  - Sakellariou, A
AU  - Limaye, A
AU  - Arns, CH
AU  - Senden, TJ
AU  - Sawkins, T
AU  - Knackstedt, MA
AU  - Rohner, D
AU  - Hutmacher, DW
AU  - Brandwood, A
AU  - Milthorpe, BK
DA  - 2004/04/01
DO  - 10.1023/B:JMSM.0000021133.48661.62
EP  - 532
JO  - Journal of Materials Science: Materials in Medicine
PY  - 2004/04/01
SP  - 529
TI  - Investigation of microstructural features in regenerating bone using micro computed tomography
VL  - 15
Y1  - 2004/04/01
Y2  - 2026/05/21
ER  -