TY  - CHAP
AB  - The recent development of cell biology techniques for bacteria to allow visualization of fundamental processes in time and space, and their use in synchronous populations of cells, has resulted in a dramatic increase in our understanding of cell division and its regulation in these tiny cells. The first stage of cell division is the formation of a Z ring, composed of a polymerized tubulin-like protein, FtsZ, at the division site precisely at midcell. Several membrane-associated division proteins are then recruited to this ring to form a complex, the divisome, which causes invagination of the cell envelope layers to form a division septum. The Z ring marks the future division site, and the timing of assembly and positioning of this structure are important in determining where and when division will take place in the cell. Z ring assembly is controlled by many factors including negative regulatory mechanisms such as Min and nucleoid occlusion that influence Z ring positioning and FtsZ accessory proteins that bind to FtsZ directly and modulate its polymerization behavior. The replication status of the cell also influences the positioning of the Z ring, which may allow the tight coordination between DNA replication and cell division required to produce two identical newborn cells. © 2006 Elsevier Inc. All rights reserved.
AU  - Harry, E
AU  - Monahan, L
AU  - Thompson, L
DA  - 2006/12/01
DO  - 10.1016/S0074-7696(06)53002-5
EP  - 94
PY  - 2006/12/01
SP  - 27
TI  - Bacterial Cell Division: The Mechanism and Its Precison
VL  - 253
Y1  - 2006/12/01
Y2  - 2026/07/08
ER  -