TY - JOUR AB - © 2016 Hyun-Ho Lee et al. Hypercholesterolemia is a well-known etiological factor for cardiovascular disease and a common symptom of most types of metabolic disorders. Camellia japonica is a traditional garden plant, and its flower and seed have been used as a base oil of traditional cosmetics in East Asia. The present study was carried out to evaluate the effect of C. japonica fruit extracts (CJF) in a high fat diet- (HFD-) induced hypercholesterolemic rat model. CJF was administered orally at three different doses: 100, 400, and 800 mg·kg-1·day-1 (CJF 100, 400, and 800, resp.). Our results showed that CJF possessed strong cholesterol-lowering potency as indicated by the decrease in serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL), accompanied by an increase in serum high-density lipoprotein (HDL). Furthermore, CJF reduced serum lipid peroxidation by suppressing the formation of thiobarbituric acid reactive substance. In addition, oil red O (ORO) staining of rat arteries showed decreased lipid-positive staining in the CJF-treated groups compared to the control HFD group. Taken together, these results suggest that CJF could be a potent herbal therapeutic option and source of a functional food for the prevention and treatment of atherosclerosis and other diseases associated with hypercholesterolemia. AU - Lee, HH AU - Paudel, KR AU - Jeong, J AU - Wi, AJ AU - Park, WS AU - Kim, DW AU - Oak, MH DA - 2016/01/01 DO - 10.1155/2016/9679867 JO - Evidence-based Complementary and Alternative Medicine PY - 2016/01/01 TI - Antiatherogenic Effect of Camellia japonica Fruit Extract in High Fat Diet-Fed Rats VL - 2016 Y1 - 2016/01/01 Y2 - 2024/03/29 ER -