TY  - JOUR
AB  - Correction on publisher's site at: https://doi.org/10.3390/nu17061083 --- Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.
AU  - Bakshi, HA
AU  - Zoubi, MSA
AU  - Faruck, HL
AU  - Aljabali, AAA
AU  - Rabi, FA
AU  - Hafiz, AA
AU  - Al-Batanyeh, KM
AU  - Al-Trad, B
AU  - Ansari, P
AU  - Nasef, MM
AU  - Charbe, NB
AU  - Satija, S
AU  - Mehta, M
AU  - Mishra, V
AU  - Gupta, G
AU  - Abobaker, S
AU  - Negi, P
AU  - Azzouz, IM
AU  - Dardouri, AAK
AU  - Dureja, H
AU  - Prasher, P
AU  - Chellappan, DK
AU  - Dua, K
AU  - Silva, MWD
AU  - Tanani, ME
AU  - McCarron, PA
AU  - M Tambuwala, M
DA  - 2020/06/26
DO  - 10.3390/nu12061901
EP  - 1901
JO  - Nutrients
PB  - MDPI AG
PY  - 2020/06/26
SP  - 1901
TI  - Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage.
VL  - 12
Y1  - 2020/06/26
Y2  - 2026/05/04
ER  -