TY - JOUR AB - Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents. © 2006 Elsevier Ltd. All rights reserved. AU - Avery, TD AU - Macreadie, PI AU - Greatrex, BW AU - Robinson, TV AU - Taylor, DK AU - Macreadie, IG DA - 2007/01/01 DO - 10.1016/j.bmc.2006.10.021 EP - 42 JO - Bioorganic and Medicinal Chemistry PY - 2007/01/01 SP - 36 TI - Design of endoperoxides with anti-Candida activity VL - 15 Y1 - 2007/01/01 Y2 - 2024/03/29 ER -