TY - JOUR AB - Background/Objectives: Lightweight CNNs for medical imaging remain limited. We propose TurkerNeXtV2, a compact CNN that introduces two new blocks: a pooling-based attention with an inverted bottleneck (TNV2) and a hybrid downsampling module. These blocks improve stability and efficiency. The aim is to achieve transformer-level effectiveness while keeping the simplicity, low computational cost, and deployability of CNNs. Methods: The model was first pretrained on the Stable ImageNet-1k benchmark and then fine-tuned on a collected plantar-pressure OA dataset. We also evaluated the model on a public blood-cell image dataset. Performance was measured by accuracy, precision, recall, and F1-score. Inference time (images per second) was recorded on an RTX 5080 GPU. Grad-CAM was used for qualitative explainability. Results: During pretraining on Stable ImageNet-1k, the model reached a validation accuracy of 87.77%. On the OA test set, the model achieved 93.40% accuracy (95% CI: 91.3-95.2%) with balanced precision and recall above 90%. On the blood-cell dataset, the test accuracy was 98.52%. The average inference time was 0.0078 s per image (?128.8 images/s), which is comparable to strong CNN baselines and faster than the transformer baselines tested under the same settings. Conclusions: TurkerNeXtV2 delivers high accuracy with low computational cost. The pooling-based attention (TNV2) and the hybrid downsampling enable a lightweight yet effective design. The model is suitable for real-time and clinical use. Future work will include multi-center validation and broader tests across imaging modalities. AU - Esmez, O AU - Deniz, G AU - Bilek, F AU - Gurger, M AU - Barua, PD AU - Dogan, S AU - Baygin, M AU - Tuncer, T DA - 2025/09/27 DO - 10.3390/diagnostics15192478 JO - Diagnostics (Basel) PB - MDPI PY - 2025/09/27 SP - 2478 TI - TurkerNeXtV2: An Innovative CNN Model for Knee Osteoarthritis Pressure Image Classification. VL - 15 Y1 - 2025/09/27 Y2 - 2026/05/01 ER -