TY  - JOUR
AB  - © 2015 Macmillan Publishers Limited. All rights reserved. Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene.
AU  - Dontschuk, N
AU  - Stacey, A
AU  - Tadich, A
AU  - Rietwyk, KJ
AU  - Schenk, A
AU  - Edmonds, MT
AU  - Shimoni, O
AU  - Pakes, CI
AU  - Prawer, S
AU  - Cervenka, J
DA  - 2015/03/24
DO  - 10.1038/ncomms7563
JO  - Nature Communications
PY  - 2015/03/24
TI  - A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases
VL  - 6
Y1  - 2015/03/24
Y2  - 2026/06/11
ER  -