TY  - JOUR
AB  - The synthesis of spiro[cyclopropane-1,3?-oxindole]-2-carboxylic acid, including novel 3-(2- and 3-pyridyl)-substituted analogues and the novel cyclopropa[c]quinoline-7b-carboxylic acid and their ester and amide derivatives is described. These syntheses involve diastereoselective cyclopropanation reactions of methyl 2-(2-nitrophenyl)acrylate and (3E)-(pyridin-2-ylmethylene)- and (3E)-(pyridin-3-ylmethylene)-1,3-dihydro-2H-indol-2-one with ethyl (dimethyl sulfuranylidene) acetate (EDSA). The synthesis of methyl cyclopropa[c]quinoline-7b-carboxylate involves a regioselective reductive cyclization of a nitro-diester precursor. The relative stereochemistry of key compounds has been determined by single-crystal X-ray structural analysis. © 2006.
AU  - Yong, SR
AU  - Ung, AT
AU  - Pyne, SG
AU  - Skelton, BW
AU  - White, AH
DA  - 2007/01/29
DO  - 10.1016/j.tet.2006.11.051
EP  - 1199
JO  - Tetrahedron
PY  - 2007/01/29
SP  - 1191
TI  - Syntheses of spiro[cyclopropane-1,3?-oxindole]-2-carboxylic acid and cyclopropa[c]quinoline-7b-carboxylic acid and their derivatives
VL  - 63
Y1  - 2007/01/29
Y2  - 2026/05/30
ER  -