http://hdl.handle.net/10453/148709 2026-04-04T22:32:05Z http://hdl.handle.net/10453/144592 Title: No gender-related bias in COPD diagnosis and treatment in Sweden: a randomised, controlled, case-based trial. Authors: Akbarshahi, H; Ahmadi, Z; Currow, DC; Sandberg, J; Vandersman, Z; Shanon-Honson, A; Ekström, M Abstract: <b>Introduction:</b>COPD is a major cause of morbidity and mortality. The prevalence, morbidity and mortality of COPD among females have increased. Previous studies indicate a possible gender bias in the diagnosis and management of COPD. The present study aims to determine if there is gender bias in the management of COPD in Sweden.<br><br><b>Methods:</b>This was a double-blind, randomised (1:1), controlled, parallel-group, web-based trial using the hypothetical case scenario of a former smoker (40 pack-years and quit smoking 3 years ago) who was male or female. The participants were blind to the randomisation and the purpose of the trial. The case progressively revealed more information with associated questions on how the physician would manage the patient. Study participants chose from a list of tests and treatments at each step of the case scenario.<br><br><b>Results:</b>In total, 134 physicians were randomised to a male (n=62) or a female (n=72) case. There was no difference in initial diagnosis (61 (98%) male cases and 70 (97%) female cases diagnosed with COPD) and planned diagnostic procedures between the male and female cases. Spirometry was chosen by all the physicians as one of the requested diagnostic tests. The management of the hypothetical COPD case did not differ by sex of the responding physician.<br><br><b>Conclusion:</b>In Sweden, diagnosis and management of a hypothetical patient with COPD did not differ by the gender of the patient or physician. 2020-10-01T00:00:00Z http://hdl.handle.net/10453/141344 Title: Health-related Quality of Life and Its Predictors in Korean Patients with Myocardial Infarction in the Acute Phase Authors: Kang, K; Gholizadeh, L; Han, HR Abstract: © The Author(s) 2019. This study aims to investigate health-related quality of life (HRQoL) of Korean patients in the acute phase of myocardial infarction (MI) and correlates of this important patient outcome. A total of 150 patients with recent MI were recruited. The Korean version of the MacNew Quality of Life after Myocardial Infarction Questionnaire was used to assess their HRQoL. Demographic, behavioural and disease-related factors were also assessed and the Depression, Anxiety and Stress Scale (DASS 21) was used for psychological well-being. Participants who had a higher education level and better financial status had better HRQoL. Diabetes, history of stroke, other heart disease and a higher score of the DASS 21 were adversely associated with HRQoL. The findings of this study help identify risk factors that are related to lower HRQoL after MI. Early psychological and financial support may help reduce the impact of MI on patients’ overall health and quality of life. 2019-01-01T00:00:00Z http://hdl.handle.net/10453/139377 Title: Subtype Specificity of Genetic Loci Associated With Stroke in 16 664 Cases and 32 792 Controls Authors: Traylor, M; Anderson, CD; Rutten-Jacobs, LCA; Falcone, GJ; Comeau, ME; Ay, H; Sudlow, CLM; Xu, H; Mitchell, BD; Cole, JW; Rexrode, K; Jimenez-Conde, J; Schmidt, R; Grewal, RP; Sacco, R; Ribases, M; Rundek, T; Rosand, J; Dichgans, M; Lee, J-M; Langefeld, CD; Kittner, SJ; Markus, HS; Woo, D; Malik, R 2019-07-01T00:00:00Z http://hdl.handle.net/10453/139373 Title: Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting Authors: Chauhan, G; Adams, HHH; Satizabal, CL; Bis, JC; Teumer, A; Sargurupremraj, M; Hofer, E; Trompet, S; Hilal, S; Smith, AV; Jian, X; Malik, R; Traylor, M; Pulit, SL; Amouyel, P; Mazoyer, B; Zhu, Y-C; Kaffashian, S; Schilling, S; Beecham, GW; Montine, TJ; Schellenberg, GD; Kjartansson, O; Gudnason, V; Knopman, DS; Griswold, ME; Windham, BG; Gottesman, RF; Mosley, TH; Schmidt, R; Saba, Y; Schmidt, H; Takeuchi, F; Yamaguchi, S; Nabika, T; Kato, N; Rajan, KB; Aggarwal, NT; De Jager, PL; Evans, DA; Psaty, BM; Rotter, JI; Rice, K; Lopez, OL; Liao, J; Chen, C; Cheng, C-Y; Wong, TY; Ikram, MK; van der Lee, SJ; Amin, N; Chouraki, V; DeStefano, AL; Aparicio, HJ; Romero, JR; Maillard, P; DeCarli, C; Wardlaw, JM; Hernandez, MDCV; Luciano, M; Liewald, D; Deary, IJ; Starr, JM; Bastin, ME; Maniega, SM; Slagboom, PE; Beekman, M; Deelen, J; Uh, H-W; Lemmens, R; Brodaty, H; Wright, MJ; Ames, D; Boncoraglio, GB; Hopewell, JC; Beecham, AH; Blanton, SH; Wright, CB; Sacco, RL; Wen, W; Thalamuthu, A; Armstrong, NJ; Chong, E; Schofield, PR; Kwok, JB; van der Grond, J; Stott, DJ; Ford, I; Jukema, JW; Vernooij, MW; Hofman, A; Uitterlinden, AG; van der Lugt, A; Wittfeld, K; Grabe, HJ; Hosten, N; von Sarnowski, B; Voelker, U; Levi, C; Jimenez-Conde, J; Sharma, P; Sudlow, CLM; Rosand, J; Woo, D; Cole, JW; Meschia, JF; Slowik, A; Thijs, V; Lindgren, A; Melander, O; Grewal, RP; Rundek, T; Rexrode, K; Rothwell, PM; Arnett, DK; Jern, C; Johnson, JA; Benavente, OR; Wasssertheil-Smoller, S; Lee, J-M; Wong, Q; Mitchell, BD; Rich, SS; McArdle, PF; Geerlings, MI; van der Graaf, Y; de Bakker, PIW; Asselbergs, FW; Srikanth, V; Thomson, R; McWhirter, R; Moran, C; Callisaya, M; Thanh, P; Rutten-Jacobs, LCA; Bevan, S; Tzourio, C; Mather, KA; Sachdev, PS; van Duijn, CM; Worrall, BB; Dichgans, M; Kittner, SJ; Markus, HS; Ikram, MA; Fornage, M; Launer, LJ; Seshadri, S; Longstreth, WT; Debette, S 2019-01-29T00:00:00Z