http://hdl.handle.net/10453/35205 2026-05-25T11:01:55Z http://hdl.handle.net/10453/195096 Title: Inter-Day Reliability of Countermovement Jump Metrics in Elite Academy Soccer Players Authors: Lonergan, B; Cohen, DD; Williams, S; Lawson, R; Howarth, DJ; Johnson, DM Abstract: The purpose of this study was to determine the inter-day reliability of countermovement jump (CMJ) force plate metrics in elite male academy soccer players. Fourteen players performed 3 CMJ s on 3 separate days over an 8-day period during a typical in-season competition and training period. Absolute (coefficient of variation (CV)) and relative reliability (interclass coefficient (ICC)) were calculated using two inter-day combinations condition 1 Monday-Tuesday, condition 2 Monday-Monday and using two data treatment methods mean of trials ( mean3 ) and single trial with the highest Flight Time Contraction Time ( BestFT CT ). In the mean3, Monday-Tuesday condition, all CV s except for peak landing force were 10 , with most 5 , while all ICC s were 0.75 (good), and most ICC s 0.9 (excellent). Several metrics had lower CV s and higher ICC s in condition 1 than condition 2 and in mean3 than BestFT CT. Importantly, in the context of using downward eccentric phase metrics in monitoring, eccentric deceleration rate of force development, durations, power and displacement within this phase demonstrated good-excellent absolute reliability (CVs between 2.9 and 7.03 ). Overall, CV s were substantially lower than most previous studies, but similar to investigations involving elite team sport athletes who also perform the CMJ regularly. Our findings suggest that metric reliability is enhanced by this exposure and by a competitive environment, and that reliability data obtained in populations without these characteristics is not generalizable to the elite setting. Practitioners should endeavor to assess inter-day reliability within their team. In-season implementation represents an ecologically valid option. http://hdl.handle.net/10453/195093 Title: The Bunya Project: Indigenous communities leading healthcare curricula Authors: Manton, D Editors: Hayen, A; Williams, MM Abstract: The Bunya Project thesis explores the integration of Aboriginal and Torres Strait Islander peoples' perspectives into healthcare education, aiming to bridge the gap between policy rhetoric and actionable strategies. Through collaborating with Indigenous healthcare providers, the Bunya Project seeks to embed Indigenous leadership and perspectives into healthcare curricula to enhance staff and student awareness of self, and the intersectionality of Indigenous experiences and health outcomes, to promote health equity. It utilises participatory action research grounded in Indigenous epistemologies, the project celebrates Indigenous expertise and advocates for community-led teaching and learning. The thesis unfolds through literature reviews, methodological outlines, findings from qualitative and quantitative data, and discussions on the potential impact and future directions. It emphasises the importance of Indigenous leadership, cultural safety, and inclusive education to improve healthcare outcomes and address systemic challenges in tertiary healthcare education, calling for ongoing research and community engagement to sustain progress. 2025-01-01T00:00:00Z http://hdl.handle.net/10453/195088 Title: The categorisation of the Short Warwick Edinburgh Mental Wellbeing Scale scores: an exploration from an epidemiological perspective Authors: Lam, LT; Lam, MK Abstract: Background There has been a notable increase in the utilisation of SWEMWBS as a measure of mental well-being globally. To enhance its interpretability for both healthcare professionals and laypeople, categorising SWEMWBS scores is considered beneficial. Two approaches have been recommended, yet they have not been thoroughly investigated. This study aimed to explore the categorisation of the scores from an epidemiological perspective. Methods Adopting PHQ-9 results, as suggested by the original scale author, to be the benchmarking comparator and employing the epidemiological approach, the concordance between SWEMWBS and PHQ-9 was examined using data from a health survey. The scales were categorised following the recommended cutoffs suggested by the authors. An additional cutoff was generated from the Nonparametric Receiver Operating Characteristic (ROC) Analysis and verified using the multiclass ROC analysis. The agreement indicators, including the sensitivity, specificity, Positive Predictive Value, Negative Predictive Value, Likelihood Ratio Positive, Likelihood Ratio Negative, and Receiver Operating Characteristic-Area Under the Curve (ROC AUC), were calculated. Results The categorisation of SWEMWBS scores by benchmarking yielded the highest sensitivity, but the smallest specificity with 86.1 (95 C.I. 84.1 -87.9 ) and 56.6 (95 C.I. 49.1 - 63.9 ) respectively. Categorisation using the mean and SD approach resulted in a sensitivity of 81.3 (95 C.I. 79.1 - 83.4 ) and a specificity of 68.1 (95 C.I. 60.8 -74.8 ). In contrast, categorisation using the ROC analysis approach provided a sensitivity of 76.5 (95 C.I. 73.8 -79.0 ) and a specificity of 77.5 (95 C.I. 70.7 -83.3 ). The ROC AUC values were moderately low with the largest being 0.769 (95 C.I. 0.737-0.802). Conclusions The concordance of the Chinese version of the SWEMWBS has been examined using PHQ-9 as the benchmarking comparator. The results indicate moderate sensitivity, specificity, LR+, and LR- values. 2025-01-01T00:00:00Z http://hdl.handle.net/10453/195087 Title: Exploring the pharmacokinetics, drug-likeness, and toxicological features of anticancer flavonoids: a Boulevard to explore their clinical translational potential Authors: Dubey, AK; Chandragiri, SS; Geevarghese, AV; Kapoor, B; Gulati, M; Rani, P; Singh, G; Chavda, VP; Gundamaraju, R; Bansal, H; Gautam, RK; Goyal, R; Okoh, MP; Shen, B; Singla, RK Abstract: Background Flavonoids that are widely distributed across various plant species exhibit significant anticancer activity in various preclinical and clinical studies, thus offering promising therapeutic prospects. However, a thorough understanding of their pharmacokinetic properties, drug-likeness characteristics, and safety profile is essential for the translational applicability of these molecules into clinical settings. Methods A systematic search was carried out using various electronic databases such as PubMed Central, ScienceDirect, Clinical Registry, and Google Scholar, using different keywords like flavonoids , cancer , pharmacokinetics , toxicity , tumor , and their combinations. Non-English literature was excluded due to language barriers, limited accessibility, non-indexing, and the risk of misinterpreting methods or results, which could compromise the accuracy and reliability of the review. Results and discussion This review provides an in-depth overview of various mechanistic pathways, such as oxidative stress-mediated and immunomodulatory pathways, that are considered to be responsible for the anti-cancer potential of flavonoids. In addition, the pharmacokinetic properties and toxicity profile of flavonoids have been discussed, which are the crucial factors in their clinical translation. Lastly, the review briefly explores various strategies that can be adopted to improve the effectiveness of flavonoids in the treatment of cancer. Conclusion This investigation enhances our understanding of the translational potential of flavonoid-based therapies by highlighting these essential elements, bringing us one step closer to the development of effective and safe cancer treatments. 2025-01-01T00:00:00Z