http://hdl.handle.net/10453/35205 2026-05-01T00:52:37Z http://hdl.handle.net/10453/194837 Title: A portable and versatile rGO-Co3O4-Pt nanocomposite-based electrochemical sensor for ex vivo and in vivo cardiac oxidative stress monitoring. Authors: Singh, S; Melini, S; Raucci, A; Numan, A; Khalid, M; Goh, BH; Meli, R; Pirozzi, C; Cinti, S Abstract: The excessive production of reactive oxygen species (ROS) disrupts redox homeostasis, contributing to the development of cardiovascular diseases. Among ROS, hydrogen peroxide (H2O2) serves as a key mediator of oxidative signaling and a critical biomarker of cellular oxidative damage due to its relative stability and signaling relevance. However, current detection strategies for ROS and H2O2 often lack the necessary sensitivity, selectivity, and real-time responsiveness, underscoring the urgent need for advanced sensing platforms to support precision cardiovascular medicine. The research introduces a ROS detection based on reduced graphene oxide-cobalt oxide-platinum (rGO-Co3O4-Pt) nanocomposites for biological sample analysis. The nanocomposite platform enables H2O2 detection down to 160 nM, with linearity up to 2.50 μM. The platform showed acceptable analytical performance in terms of sensitivity, repeatability, and selectivity, which enabled both ex vivo and in vivo H2O2 monitoring. The method was validated in doxorubicin (DOX)-induced cardiotoxicity models using HL-1 cells and C57BL/6J mice, showing strong correlation with MTT-based ROS assays. The rGO-Co3O4-Pt nanocomposite improves portable analytical devices for real-world pharmacological applications. The technology enables real-time therapeutic monitoring while optimizing individualized dosing and expanding its applications to cancer treatment and diabetes management and neurological disorders. 2025-11-20T00:00:00Z http://hdl.handle.net/10453/194810 Title: A scoping review of the pharmacovigilance systems in west African region Authors: Jalloh, I; James, PB; Abiri, OT; Wiafe, E; Mensah, K; Padayachee, N Abstract: Background: Pharmacovigilance is essential for monitoring drug safety and managing adverse drug reactions, particularly In the context of Increasing médication use In West Africa. This review alms to assess the existing state of pharmacovigilance systems, regulatory frameworks, and adverse drug reaction reporting practices across the West African region. Methods: A systematic scoping review was performed in accordance with the methodology set out by the Joanna Briggs Institute, adhering to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) guidelines. Literature searches conducted across seven databases resulted In 3,000 documents, of which 59 studies met the Inclusion criteria. The Included studies originated from six countries: Ghana, Nigeria, Burkina Faso, Côte d’Ivoire, Sierra Leone, and Senegal. Key themes identified In the review encompass pharmacovigilance systems, related policies, collaboration among stakeholders, and the challenges associated with reporting adverse drug reactions. Results: While all West African countries have established national pharmacovigilance centers and WHO Collaborating Center membership, gaps persist in legislation, enforcement, and public awareness. Challenges include inadequate resources, limited healthcare professional training, and communication barriers. Recommendations emphasize education, stakeholder engagement, and public awareness to improve adverse drug reaction reporting. Conclusion: Strengthening pharmacovigilance in West Africa requires a multipronged approach prioritizing policy, collaboration, and education to ensure drug safety and public health. 2025-01-01T00:00:00Z http://hdl.handle.net/10453/194745 Title: LOVE AND THE HUMANISATION OF CHILDBIRTH Authors: Page, L; Wardhaugh, C Abstract: These letters form a conversation between Lesley Page, an experienced midwife who has worked to humanise childbirth over many years, and Clare Wardhaugh. Clare, through her work in education, person-centred counselling and embodied spiritual direction, has enabled practitioners to authentically practise personal beliefs in their workplace with integrity, critical thinking, and values of love. In writing these letters, we are thinking about midwifery, we consider the life of the midwife, the concept of love, and the key to that love in humanising midwifery. We will also consider the role of the organisation and whether it is one that helps the midwife to offer of their best or makes it more difficult. The exploration from different perspectives will consider midwifery in conjunction with theology, philosophy, and spirituality, which we hope will illuminate the importance of love to our lives, and love in midwifery practice. We hope that through this conversation, midwives and others reading it will be inspired to think about what love means and reflect on the place of love in their lives, their practice, and in the systems and cultures in which they work. 2025-01-01T00:00:00Z http://hdl.handle.net/10453/194574 Title: The Effectiveness of Body Image Flexibility Interventions in Youth: A Systematic Review with Meta-Analysis Authors: Brichacek, AL; Neill, JT; Murray, K; Rieger, E; Watsford, C Abstract: Prevention programs that focus on enhancing positive body image may improve health and well-being in young people. Body image flexibility is a promising prevention approach, although its application with youth has yet to be comprehensively investigated. This systematic review evaluated the effectiveness of body image flexibility interventions among adolescents and emerging adults. There were 23 eligible studies (N = 2764, 91.3% female) published between 2004 and 2024. Random effects meta-analyses indicated that body image flexibility interventions led to immediate, g = 0.52 (13 studies, n = 1,045), and sustained, g = 0.27 (8 studies, n = 608, 1-week to 24-month follow-up) improvements in health outcomes and protected against adverse effects of body image threats, g = 0.33 (7 studies, n = 480), relative to no/minimal intervention controls. Improvements were largely attributable to reductions in body image concerns. Comparison with other evidence-based interventions, including cognitive and dissonance-based programs, suggested comparable effects. Randomized trials and universal programs demonstrated smaller improvements, and there was evidence of potential publication bias. Conclusions are thus limited by the quantity and quality of existing studies, with most focusing on emerging adult females. Recommendations are provided to address these limitations in future research and strengthen the reliability and generalizability of results. 2025-09-01T00:00:00Z