http://hdl.handle.net/10453/35207 2026-06-10T02:18:53Z http://hdl.handle.net/10453/195229 Title: Amide-imidol tautomerism based fluorescence turn-on probe for selective detection of fluoride ion through restricted intramolecular rotation. Authors: Khurshid, K; Saeed, S; Assiri, MA; Shabbir, A; Shahzad, SA Abstract: Fluoride ions play a crucial role in many biological functions such as bone disease treatment, water fluoridation, and caries many other treatments. Excessive intake of fluoride ions causes chronic diseases such as Arthritis, oxidative stress, brittle bones, brain damage, and cancer. With these reasons, a cost-effective and highly specific probe 3PDA have been developed for real-time monitoring of fluoride ions. Probe 3PDA is a pyridine-based "Turn-On" sensor, easily synthesized through the Schotten-Baumann reaction. This pyridine based probe demonstrated interesting optical characteristics such as large Stoke's shift (109 nm), solvatochromism, pH sensing, and ACQ behavior. Furthermore, probe 3PDA was effectively utilized for nanomolar (nM) sensing of fluoride ions through covalent interactions. UV-visible, fluorescence, and 1H NMR titration analyses were executed to verify amide-imidol tautomerism as a sensing mechanism. Amide-imidol tautomerism become highly favorable when fluoride interacts with probe 3PDA molecule. Fluoride ion as a strong hydrogen bond acceptor facilitates the conversion of amide form into imidol tautomer and causes restriction of intramolecular rotation (RIR) of bonds. Overall, presence of fluoride ions makes probe 3PDA molecule more rigid and less flexible. Moreover, DLS analysis was executed to verify the formation of aggregation and excimer disaggregation. DFT studies were employed to validate the sensitivity of probe 3PDA toward fluoride ions. The calculated LOD was 150 nM and LOQ was 502 nM for fluoride ion detection. Probe 3PDA was employed for naked eye solid state sensing of fluoride ions under daylight and UV irradiation at 365 nm. Furthermore, 3PDA was practically applied to estimate fluoride concentration in oral care products, mineral water, and spiked lake water. 3PDA-coated TLC strips were also designed as tiny portable tools for fluoridesensing. 2025-11-15T00:00:00Z http://hdl.handle.net/10453/195205 Title: Layered P2/P3-intergrowth cathode materials with biphasic interlocking towards stable potassium (de)intercalation Authors: Tang, Y; Zhu, X; Cheng, C; Zhao, L; Gu, Q; Dong, H; Liu, M; Tang, W; Wei, GX; Feng, YH; Zhang, L; Xiao, B; Wang, PF Abstract: Potassium layered oxide cathodes usually deliver diverse prismatic-coordinated structural chemistry, enabling to explore thermodynamic-stable P2/P3 biphasic structures to tailor the electrochemical properties for potassium-ion batteries (PIBs). However, their intrinsic thermodynamic phase preference and complex electrochemical reaction mechanism in terms of phase evolution, charge compensation and stress response remain unclear. With this perspective, a P2/P3 biphasic cathode material-K<inf>x</inf>Li<inf>0.03</inf>Mg<inf>0.03</inf>Ti<inf>0.07</inf>Ni<inf>0.1</inf>Mn<inf>0.77</inf>O<inf>2</inf> with a specific phase proportion (P2: P3 = 35.2 %: 64.8 %) is designed under the guidance of first principles calculation. Benefiting from the interfacial interlocking effect at the phase boundary, the sliding of TM layers is well inhibited. Moreover, the different orientation of P2 and P3 crystalline domain serves to mitigate long range Jahn-Teller ordering of MnO<inf>6</inf> octahedron, lattice mismatch and mechanical stress. Consequently, the P2/P3 biphasic cathode exhibits a high capacity of 110.8 mA h g⁻¹ at 0.2 C and good cycling stability of 82.0 % after 150 cycles at 1 C. This work provides insightful guidelines to develop stable biphasic cathode materials through thermodynamic phase modulation for high-performance PIBs. 2025-10-01T00:00:00Z http://hdl.handle.net/10453/195178 Title: AORI-HAP: a multidimensional risk index to predict in-hospital adverse outcomes in asthma exacerbations. Authors: Yuan, L; Zhao, C; Wang, L; Zhang, L; Liu, Y; Liu, L; Feng, M; Melén, E; Wang, G; Zhang, S; Yuan, Y; Wang, Q; Li, Y; Kang, D; Zhang, X Abstract: BACKGROUND: Despite therapeutic advancements, asthma exacerbations (AEs) remain a major clinical challenge, with immune-inflammatory patterns incompletely characterized. Current guidelines lack robust multidimensional tools for predicting in-hospital adverse outcomes. OBJECTIVE: To develop and validate the Asthma Outcome Risk Index for Hospitalized Patients (AORI-HAP), integrating multidimensional predictors, and investigate immune-inflammatory mechanisms underlying adverse outcomes. METHODS: This real-world cohort study enrolled hospitalized AE patients. Univariate analyses identified associations between multidimensional biomarkers and composite outcome (death, ICU admission, invasive ventilation). LASSO logistic regression derived the AORI-HAP, stratifying patients into risk categories. Mediation analysis elucidated mechanistic contributions to adverse outcomes. RESULTS: The AORI-HAP identified five independent predictors of adverse outcomes: elevated neutrophil-to-lymphocyte ratio (NLR > 8.3, OR = 9.26, p < 0.001), increased AST/ALT ratio (>1.41, OR = 3.73, p < 0.001), smoking history ≥10 pack-years (OR = 3.54, p = 0.005), D-Dimer levels ≥5 mg/L (OR = 3.25, p = 0.002), and fasting glucose ≥7 mmol/L (OR = 3.20, p = 0.001). Each 3-point increment in the AORI-HAP score corresponded to an additional hospital day (β = 0.997, 95% CI: 0.78-1.21, p < 0.001), with the model demonstrating strong predictive performance (AUC 0.91, 95% CI 0.86-0.95; sensitivity 90.5%, specificity 69.6%). Mediation analysis revealed that NLR accounted for 26.7% of the total effect linking high-risk status to composite adverse outcome, underscoring its mechanistic relevance. CONCLUSION: AORI-HAP facilitates early risk stratification at admission and personalized management in hospitalized asthma patients. NLR's mediating role underscores its utility as a predictive biomarker and potential therapeutic target. 2025-01-01T00:00:00Z http://hdl.handle.net/10453/195169 Title: Indigenous peoples’ voices and engagement on climate change: towards improved health and wellbeing Authors: Lansbury, N; Mosby, V; Creamer, SJ; Moggridge, B; Evans, GR; Pecl, G; Ireland, L Abstract: Western climate science largely fails to value, engage with and apply Indigenous Knowledges in a meaningful way. Here, we explore the ways in which the current gap in Indigenous Knowledges and representation in climate research can be addressed. A rapid review of relevant literature and grey materials was conducted to identify how Aboriginal and Torres Strait Islander Peoples, and the essential Knowledges they hold, should and will inform and direct climate change research. This timely review of academic and grey literature to inform a wider public conversation of Indigenous leadership, voices and participation in climate change discussions, in and beyond the Intergovernmental Panel on Climate Change (IPCC) process, both in Australia and with consequences internationally. 2025-01-01T00:00:00Z