http://hdl.handle.net/10453/35220 2026-06-10T10:04:49Z http://hdl.handle.net/10453/195205 Title: Layered P2/P3-intergrowth cathode materials with biphasic interlocking towards stable potassium (de)intercalation Authors: Tang, Y; Zhu, X; Cheng, C; Zhao, L; Gu, Q; Dong, H; Liu, M; Tang, W; Wei, GX; Feng, YH; Zhang, L; Xiao, B; Wang, PF Abstract: Potassium layered oxide cathodes usually deliver diverse prismatic-coordinated structural chemistry, enabling to explore thermodynamic-stable P2/P3 biphasic structures to tailor the electrochemical properties for potassium-ion batteries (PIBs). However, their intrinsic thermodynamic phase preference and complex electrochemical reaction mechanism in terms of phase evolution, charge compensation and stress response remain unclear. With this perspective, a P2/P3 biphasic cathode material-K<inf>x</inf>Li<inf>0.03</inf>Mg<inf>0.03</inf>Ti<inf>0.07</inf>Ni<inf>0.1</inf>Mn<inf>0.77</inf>O<inf>2</inf> with a specific phase proportion (P2: P3 = 35.2 %: 64.8 %) is designed under the guidance of first principles calculation. Benefiting from the interfacial interlocking effect at the phase boundary, the sliding of TM layers is well inhibited. Moreover, the different orientation of P2 and P3 crystalline domain serves to mitigate long range Jahn-Teller ordering of MnO<inf>6</inf> octahedron, lattice mismatch and mechanical stress. Consequently, the P2/P3 biphasic cathode exhibits a high capacity of 110.8 mA h g⁻¹ at 0.2 C and good cycling stability of 82.0 % after 150 cycles at 1 C. This work provides insightful guidelines to develop stable biphasic cathode materials through thermodynamic phase modulation for high-performance PIBs. 2025-10-01T00:00:00Z http://hdl.handle.net/10453/195178 Title: AORI-HAP: a multidimensional risk index to predict in-hospital adverse outcomes in asthma exacerbations. Authors: Yuan, L; Zhao, C; Wang, L; Zhang, L; Liu, Y; Liu, L; Feng, M; Melén, E; Wang, G; Zhang, S; Yuan, Y; Wang, Q; Li, Y; Kang, D; Zhang, X Abstract: BACKGROUND: Despite therapeutic advancements, asthma exacerbations (AEs) remain a major clinical challenge, with immune-inflammatory patterns incompletely characterized. Current guidelines lack robust multidimensional tools for predicting in-hospital adverse outcomes. OBJECTIVE: To develop and validate the Asthma Outcome Risk Index for Hospitalized Patients (AORI-HAP), integrating multidimensional predictors, and investigate immune-inflammatory mechanisms underlying adverse outcomes. METHODS: This real-world cohort study enrolled hospitalized AE patients. Univariate analyses identified associations between multidimensional biomarkers and composite outcome (death, ICU admission, invasive ventilation). LASSO logistic regression derived the AORI-HAP, stratifying patients into risk categories. Mediation analysis elucidated mechanistic contributions to adverse outcomes. RESULTS: The AORI-HAP identified five independent predictors of adverse outcomes: elevated neutrophil-to-lymphocyte ratio (NLR > 8.3, OR = 9.26, p < 0.001), increased AST/ALT ratio (>1.41, OR = 3.73, p < 0.001), smoking history ≥10 pack-years (OR = 3.54, p = 0.005), D-Dimer levels ≥5 mg/L (OR = 3.25, p = 0.002), and fasting glucose ≥7 mmol/L (OR = 3.20, p = 0.001). Each 3-point increment in the AORI-HAP score corresponded to an additional hospital day (β = 0.997, 95% CI: 0.78-1.21, p < 0.001), with the model demonstrating strong predictive performance (AUC 0.91, 95% CI 0.86-0.95; sensitivity 90.5%, specificity 69.6%). Mediation analysis revealed that NLR accounted for 26.7% of the total effect linking high-risk status to composite adverse outcome, underscoring its mechanistic relevance. CONCLUSION: AORI-HAP facilitates early risk stratification at admission and personalized management in hospitalized asthma patients. NLR's mediating role underscores its utility as a predictive biomarker and potential therapeutic target. 2025-01-01T00:00:00Z http://hdl.handle.net/10453/195169 Title: Indigenous peoples’ voices and engagement on climate change: towards improved health and wellbeing Authors: Lansbury, N; Mosby, V; Creamer, SJ; Moggridge, B; Evans, GR; Pecl, G; Ireland, L Abstract: Western climate science largely fails to value, engage with and apply Indigenous Knowledges in a meaningful way. Here, we explore the ways in which the current gap in Indigenous Knowledges and representation in climate research can be addressed. A rapid review of relevant literature and grey materials was conducted to identify how Aboriginal and Torres Strait Islander Peoples, and the essential Knowledges they hold, should and will inform and direct climate change research. This timely review of academic and grey literature to inform a wider public conversation of Indigenous leadership, voices and participation in climate change discussions, in and beyond the Intergovernmental Panel on Climate Change (IPCC) process, both in Australia and with consequences internationally. 2025-01-01T00:00:00Z http://hdl.handle.net/10453/195084 Title: Prior exposure strongly influences mechanisms underpinning survival of heat shock in Escherichia coli Authors: Yasir, M; Turner, AK; Bastkowski, S; Jarvis, CS; Sweet, R; Truong, M; Charles, IG; Webber, MA Abstract: The heat shock response of i Escherichia coli /i represents a canonical example of how bacteria can recognize a stress and invoke a protective response by altering specific gene regulation. However, most understanding of the processes involved arises from experiments where cells have been subjected to immediate heat shock. In this study, we identified the populations of transposon mutants in i E. coli /i BW25113 involved in response to sudden heat shock and stepwise heat stress conditions. We used Transposon-Directed Insertion Site Sequencing with expression (TraDIS- i Xpress /i ) to identify genes whose function or expression contributed to survival under 5 different heat conditions. These conditions included direct exposure to 44 C, 47 C, or 50 C referred to as heat shock or half an hour exposure at 44 C, followed by exposure to 47 C or 50 C referred to as stepwise heat stress .A total of 530 genes were identified as contributing to one or more of the heat stress conditions tested, including known heat shock resistance genes. Only 8 genes were common to all 5 conditions, with 4 of these 8 genes being associated with energy generation. The results showed fundamentally different responses between shock and stepwise stress. In heat shock conditions, most genes conferring a fitness benefit contained an increase in insertions (loss of function) as compared to the control (37 C), while in stepwise heat stress, most genes conferring a fitness benefit had fewer insertions (representing protection of function) as compared to the control. Cell envelope genes involved in lipopolysaccharide biosynthesis ( i lpxM, lptC /i ), the Tol-Pal system ( i tolABQR-pal /i ), and outer membrane biogenesis (BAM complex) were detrimental during heat shock but essential for stepwise adaptation, while regulatory genes i relA /i (stringent response) and the i rsx /i operon (redox regulation) were specifically required for stepwise heat stress response.Prior exposure to sub-lethal heat stress 2025-01-01T00:00:00Z