http://hdl.handle.net/10453/35222 2026-08-10T09:51:22Z http://hdl.handle.net/10453/195599 Title: Defining next steps in the clinical implementation of polygenic scores: A landscape analysis of professional groups' perspectives. Authors: Purvis, R; Forrest, LE; Young, M-A; Limb, S; James, P; Taylor, N Abstract: PURPOSE: Professional perspectives on polygenic scores (PGS) have surged in-line with significant research investment. It is unclear whether these perspectives are leading the health care sector toward a comprehensive implementation approach. This scoping review addresses this knowledge gap, analyzing available publications for concurring and discordant perspectives. METHODS: Methodology followed the Arksey and O'Malley framework. Six databases were systematically searched alongside screening of professional websites. Descriptive and deductive content analyses were completed using the Consolidated Framework for Implementation Research and the Expert Recommendations for Implementing Change compilation. RESULTS: A total of 28 perspectives were analyzed. Implementation was supportable if evidentiary thresholds for clinical utility could be met, with exceptions being in vitro fertilization and prenatal settings. Evidence base and relative advantage of PGS were the strongest determinants of implementation success, with resourcing also being emphasized. Key strategies included ongoing research, developing education materials, and facilitating relay of information. Attention was not paid to leadership nor to stakeholder interrelationships. There was no recommended framework to facilitate the clinical implementation of PGS. CONCLUSION: The steps toward executing implementation remain vague. Commonalities in perspectives suggest value in a transferable approach. If PGS are to be successful, policy makers and leaders must consider effective resource allocation by addressing priority barriers and utilizing implementation methodologies. Continuing efforts to establish PGS clinical utility and value, guidelines and policies, and educational materials are needed. 2025-06-01T00:00:00Z http://hdl.handle.net/10453/194853 Title: How simple can a treatment for early stuttering be? A proposed two-factor early intervention Authors: Onslow, M; Hearne, A; Yu, K; O'Brian, S; Menzies, R; Lowe, R Abstract: In this clinical focus article, we draw attention to the need for immediate intervention shortly after stuttering onset. More than half of stuttering onsets occur before 3 years of age. We argue that existing interventions for preschool children who stutter require varying levels of cognitive engagement from children; hence, they are not suitable for children of that age. For this reason, we argue that there is no clinical trials evidence for treatment efficacy with children younger than 3 years of age. There are many recommended parent strategies that do not require any active participation from children, which, therefore, may be suitable for immediate stuttering intervention. Two of these have laboratory support in their favor: parent speech rate reduction and increased interturn speaker latency. Therefore, we developed a clinical protocol based on those two parent strategies and showed the clinical viability of the protocol with three children who stuttered. We argue that automation of our proposed treatment with lifelike artificial intelligence–generated avatar clinicians will make it globally viable, and a suitable target for future Phases I–IV clinical trials. 2026-03-10T00:00:00Z http://hdl.handle.net/10453/194852 Title: A Phase I trial of iLidcombe: Online treatment for young children who stutter Authors: Ross, F; Onslow, M; Jones, M; Menzies, R; Packman, A; O'Brian, S; Hearne, A; Lowe, R Abstract: AIM: The aim of this Phase I trial was to assess the safety, compliance, and potential efficacy of iLidcombe, a standalone internet version of the Lidcombe Program for young children who stutter. METHOD: We used a prospective single-group design involving 6 months of access to iLidcombe. Assessments occurred pretreatment and after 6 months of access. Participants were 20 parents of young children who stuttered. RESULTS: There was evidence of stuttering severity reduction after using iLidcombe for 6 months. Compliance with the program was favorable, and there was no suggestion of any psychologically adverse impact on children. CONCLUSION: The results of this Phase I trial provide a roadmap for further Phases II-IV clinical trial development. 2026-04-27T00:00:00Z http://hdl.handle.net/10453/188088 Title: Sexuality and Intimacy Authors: Power, E; McGrath, M; Lever, S 2024-01-01T00:00:00Z