Spider Venom Peptides

Nicholson, GM

Spider Venom Peptides

Nicholson, GM

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Publication Type:: Chapter
Citation:: Handbook of Biologically Active Peptides, 2006, pp. 369 - 379
Issue Date:: 2006-12-01

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Field	Value	Language
dc.contributor.author	Nicholson, GM https://orcid.org/0000-0002-4277-4296	en_US
dc.date.issued	2006-12-01	en_US
dc.identifier.citation	Handbook of Biologically Active Peptides, 2006, pp. 369 - 379	en_US
dc.identifier.isbn	9780123694423	en_US
dc.identifier.uri	http://hdl.handle.net/10453/12750
dc.description.abstract	Spider venom peptides and protein toxins are recognized as highly potent and specific molecular tools that modulate neurotransmission via interaction with a variety of ion channels, receptors, and transporters in vertebrates and invertebrates. Spiders have, during their evolution, developed a complex preoptimized combinatorial peptide library of enzymes, neurotoxins, and antimicrobial and cytolytic peptides in their venom glands. The role of spider venom is to paralyze and/or kill prey or predators as rapidly as possible. Therefore, their venoms are particularly rich in neurotoxins that rapidly modify ion conductance (ion channel toxins) and to a lesser extent affect neurotransmitter exocytosis (presynaptic toxins) and interfere with the binding of neurotransmitters (postsynaptic toxins). Many of these peptides are selectively insecticidal or modulate the activity of various targets in vertebrates, including humans. In particular, insect-selective atracotoxins are now being investigated for their possible use as bioinsecticidal agents for the control of phytophagous pests or insect vectors of new or reemerging disease. © 2006 Elsevier Inc. All rights reserved.	en_US
dc.relation.ispartof	Handbook of Biologically Active Peptides	en_US
dc.relation.isbasedon	10.1016/B978-012369442-3/50057-X	en_US
dc.title	Spider Venom Peptides	en_US
dc.type	Chapter
utslib.for	060108 Protein Trafficking	en_US
utslib.for	111506 Toxicology (incl. Clinical Toxicology)	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US

Abstract:

Spider venom peptides and protein toxins are recognized as highly potent and specific molecular tools that modulate neurotransmission via interaction with a variety of ion channels, receptors, and transporters in vertebrates and invertebrates. Spiders have, during their evolution, developed a complex preoptimized combinatorial peptide library of enzymes, neurotoxins, and antimicrobial and cytolytic peptides in their venom glands. The role of spider venom is to paralyze and/or kill prey or predators as rapidly as possible. Therefore, their venoms are particularly rich in neurotoxins that rapidly modify ion conductance (ion channel toxins) and to a lesser extent affect neurotransmitter exocytosis (presynaptic toxins) and interfere with the binding of neurotransmitters (postsynaptic toxins). Many of these peptides are selectively insecticidal or modulate the activity of various targets in vertebrates, including humans. In particular, insect-selective atracotoxins are now being investigated for their possible use as bioinsecticidal agents for the control of phytophagous pests or insect vectors of new or reemerging disease. © 2006 Elsevier Inc. All rights reserved.

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http://hdl.handle.net/10453/12750