Peroxiredoxin: a central player in immune modulation.

Publisher:
Wiley-Blackwell
Publication Type:
Journal Article
Citation:
Parasite Immunology, 2010, 32 (5), pp. 305 - 313
Issue Date:
2010-01
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Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.
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