Human Stimulus Factor Is a Promising Peptide for Delivery of Therapeutics.

Publisher:
Elsevier
Publication Type:
Journal Article
Citation:
Journal of Pharmaceutical Sciences, 2019, 108, (4), pp. 1401-1403
Issue Date:
2019-04
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Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. This was attributed to transcellular-mediated uptake. This HSF is a promising peptide for delivery of therapeutics where enhanced epithelial penetrating is required.
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