The Immuno-Mass Spectrometry Chemical Microscope

Publication Type:
Journal Article
Trends in Chemistry, 2020, 2, (5), pp. 403-406
Issue Date:
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© 2020 Elsevier Inc. Elemental mass spectrometry (MS) imaging has evolved beyond mapping biometals in tissue sections. The continually improving sensitivity and spatial resolution of chemical imaging technology has the potential to revolutionize immunohistochemistry (IHC). We explore how simple modifications to routine immunostaining protocols that integrate ‘immuno-MS imaging’ (iMSI) are making in situ quantitative protein mapping a reality.
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