Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation.

Prieto-García, A; Castells, MC; Hansbro, PM; Stevens, RL

Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation.

Prieto-García, A Castells, MC Hansbro, PM Stevens, RL

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Publisher:: W B SAUNDERS CO-ELSEVIER INC
Publication Type:: Journal Article
Citation:: Immunology and allergy clinics of North America, 2014, 34, (2), pp. 263-281
Issue Date:: 2014-05

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Field	Value	Language
dc.contributor.author	Prieto-García, A
dc.contributor.author	Castells, MC
dc.contributor.author	Hansbro, PM
dc.contributor.author	Stevens, RL
dc.date.accessioned	2021-03-04T00:57:36Z
dc.date.available	2021-03-04T00:57:36Z
dc.date.issued	2014-05
dc.identifier.citation	Immunology and allergy clinics of North America, 2014, 34, (2), pp. 263-281
dc.identifier.issn	0889-8561
dc.identifier.issn	1557-8607
dc.identifier.uri	http://hdl.handle.net/10453/146745
dc.description.abstract	Tetramer-forming tryptase (hTryptase-β) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-β is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-β could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-β has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.
dc.format	Print-Electronic
dc.language	eng
dc.publisher	W B SAUNDERS CO-ELSEVIER INC
dc.relation.ispartof	Immunology and allergy clinics of North America
dc.relation.isbasedon	10.1016/j.iac.2014.01.001
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	1107 Immunology
dc.subject.classification	Allergy
dc.subject.mesh	Mast Cells
dc.subject.mesh	Skin
dc.subject.mesh	Humans
dc.subject.mesh	Mastocytosis
dc.subject.mesh	Anaphylaxis
dc.subject.mesh	Histamine
dc.subject.mesh	Thrombin
dc.subject.mesh	Isoenzymes
dc.subject.mesh	Fibrinogen
dc.subject.mesh	Fibrin
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Gene Expression Regulation, Neoplastic
dc.subject.mesh	Blood Coagulation
dc.subject.mesh	Tryptases
dc.subject.mesh	Protein Multimerization
dc.subject.mesh	Anaphylaxis
dc.subject.mesh	Blood Coagulation
dc.subject.mesh	Fibrin
dc.subject.mesh	Fibrinogen
dc.subject.mesh	Gene Expression Regulation, Neoplastic
dc.subject.mesh	Histamine
dc.subject.mesh	Humans
dc.subject.mesh	Isoenzymes
dc.subject.mesh	Mast Cells
dc.subject.mesh	Mastocytosis
dc.subject.mesh	Protein Multimerization
dc.subject.mesh	Signal Transduction
dc.subject.mesh	Skin
dc.subject.mesh	Thrombin
dc.subject.mesh	Tryptases
dc.title	Mast cell-restricted tetramer-forming tryptases and their beneficial roles in hemostasis and blood coagulation.
dc.type	Journal Article
utslib.citation.volume	34
utslib.location.activity	United States
utslib.for	1107 Immunology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney
utslib.copyright.status	closed_access	*
dc.date.updated	2021-03-04T00:57:35Z
pubs.issue	2
pubs.publication-status	Published
pubs.volume	34
utslib.citation.issue	2

Abstract:

Tetramer-forming tryptase (hTryptase-β) was recently discovered to have a prominent role in preventing the internal accumulation of life-threatening fibrin deposits and fibrin-platelet clots. The anticoagulant activity of hTryptase-β is an explanation for the presence of hemorrhagic disorders in some patients with anaphylaxis or mastocytosis. The fragments of hFibrinogen formed by the proteolysis of this prominent protein by hTryptase-β could be used as biomarkers in the blood and/or urine for the identification and monitoring of patients with mast cell-dependent disorders. Recombinant hTryptase-β has potential to be used in clinical settings where it is desirable to inhibit blood coagulation.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/146745