Changing the time under tension: effects of different forms of concurrent training on inflammatory and cardiometabolic disease indicators

Allen, Nicholas G.

Changing the time under tension: effects of different forms of concurrent training on inflammatory and cardiometabolic disease indicators

Allen, Nicholas G.

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Publication Type:: Thesis
Issue Date:: 2020

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Field	Value	Language
dc.contributor.author	Allen, Nicholas G.
dc.date.accessioned	2021-03-17T04:00:34Z
dc.date.available	2021-03-17T04:00:34Z
dc.date.issued	2020
dc.identifier.uri	http://hdl.handle.net/10453/147290
dc.description	University of Technology Sydney. Faculty of Health.	en_US
dc.description.abstract	This thesis examines the effects of different forms of concurrent exercise training (CET) on physiological biomarkers related to cardiometabolic disease risk. Specifically, a modification of CET to emphasise muscle time-under-tension (TUT) during the resistance component is examined as a potential alternative for a population of sedentary older adults. The present thesis seeks to compare conventional CET methods to a modified version (i.e. TUT) on blood-based biomarkers related to systemic inflammation, glucose homeostasis, and cardiovascular disease (CVD) risk. Secondary outcomes include whole-body and regional tissue composition, ultrasound-derived muscular thickness, and physical fitness measures. Further, a greater understanding of the relationship between training stimuli and key functional outcomes is explored. Data derived from the present investigation is presented within three distinct studies. Firstly, study 1 explored the effect of CET versus TUT on biomarkers related to T2DM, namely inflammatory cytokines (IL-6 and TNFα) and markers of glucose homeostasis, alongside body composition and physical capacity measures. Study 2 describes the effect of these training modalities on CVD-related parameters, including blood-based measures of platelet activity and endothelial function, as well as region-specific fat mass and physical fitness. Finally, study 3 examines the relationship between selected predictor variables (aerobic capacity, muscular strength, and whole-body lean and fat mass) and key prognostic disease indicators (IL-6, TNFα and insulin resistance). A secondary aim of study 3 is to assess the dose-specific response of CET and TUT by quantifying the relationship between overall training volumes and the associated changes in the abovementioned biomarkers. […]	en_US
dc.format	Thesis (PhD)
dc.language.iso	en	en_US
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/147290/2/02whole.pdf
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	au.edu.uts.lib/ppc
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Changing the time under tension: effects of different forms of concurrent training on inflammatory and cardiometabolic disease indicators	en_US
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

This thesis examines the effects of different forms of concurrent exercise training (CET) on physiological biomarkers related to cardiometabolic disease risk. Specifically, a modification of CET to emphasise muscle time-under-tension (TUT) during the resistance component is examined as a potential alternative for a population of sedentary older adults. The present thesis seeks to compare conventional CET methods to a modified version (i.e. TUT) on blood-based biomarkers related to systemic inflammation, glucose homeostasis, and cardiovascular disease (CVD) risk. Secondary outcomes include whole-body and regional tissue composition, ultrasound-derived muscular thickness, and physical fitness measures. Further, a greater understanding of the relationship between training stimuli and key functional outcomes is explored. Data derived from the present investigation is presented within three distinct studies. Firstly, study 1 explored the effect of CET versus TUT on biomarkers related to T2DM, namely inflammatory cytokines (IL-6 and TNFα) and markers of glucose homeostasis, alongside body composition and physical capacity measures. Study 2 describes the effect of these training modalities on CVD-related parameters, including blood-based measures of platelet activity and endothelial function, as well as region-specific fat mass and physical fitness. Finally, study 3 examines the relationship between selected predictor variables (aerobic capacity, muscular strength, and whole-body lean and fat mass) and key prognostic disease indicators (IL-6, TNFα and insulin resistance). A secondary aim of study 3 is to assess the dose-specific response of CET and TUT by quantifying the relationship between overall training volumes and the associated changes in the abovementioned biomarkers. […]

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