Characterising Quantitative Spontaneous Retinal Venous Pulsations in Glaucoma

Shariflou, Sahar

Characterising Quantitative Spontaneous Retinal Venous Pulsations in Glaucoma

Shariflou, Sahar

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Publication Type:: Thesis
Issue Date:: 2022

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Field	Value	Language
dc.contributor.author	Shariflou, Sahar
dc.date.accessioned	2022-09-12T00:25:33Z
dc.date.available	2022-09-12T00:25:33Z
dc.date.issued	2022
dc.identifier.uri	http://hdl.handle.net/10453/161722
dc.description	University of Technology Sydney. Graduate School of Health.	en_US.UTF-8
dc.description.abstract	Spontaneous retinal venous pulsations (SVPs) are a dynamic vascular marker for glaucoma but have been variably reported in people with glaucoma. However, current assessment methods pose limitations that render SVP detection unfeasible for glaucoma screening and assessment. This thesis explores the effectiveness of a novel tablet-based ophthalmoscope in detecting and quantifying SVPs in glaucoma. SVP amplitudes were extracted from fundus videos using a custom-written algorithm from 170 participants with a confirmed diagnosis of glaucoma or a glaucoma suspect. SVP’s association with established clinical structural and functional markers for glaucoma were assessed. SVPs were detected and quantified in all participants and were found to be comparable to standard structural markers for distinguishing confirmed glaucoma from glaucoma suspects cases. SVPs were found to differentiate different types of confirmed glaucoma as effectively as measures of intraocular pressure. The tablet-based ophthalmoscope overcomes many disadvantages of current SVP assessment techniques. As the detected SVPs are associated with early clinical markers of glaucoma, they may be used in the early detection of glaucoma and ongoing evaluation and management, potentially limiting glaucoma related vision loss. Further studies are required to determine whether longitudinal changes in SVPs reflect glaucomatous progression.	en_US.UTF-8
dc.format	Thesis (PhD)
dc.language.iso	en_US	en_US.UTF-8
dc.relation	https://opus.lib.uts.edu.au/bitstream/10453/161722/2/02whole.pdf
dc.rights	The author owns the copyright in this thesis including all reproduction and reuse rights for the work. The work may not be altered without the permission of the copyright owner. Attribution is essential when quoting or paraphrasing from this thesis.
dc.rights	au.edu.uts.lib/ppc
dc.rights	info:eu-repo/semantics/openAccess
dc.title	Characterising Quantitative Spontaneous Retinal Venous Pulsations in Glaucoma	en_US.UTF-8
dc.type	Thesis
utslib.copyright.status	open_access	*

Abstract:

Spontaneous retinal venous pulsations (SVPs) are a dynamic vascular marker for glaucoma but have been variably reported in people with glaucoma. However, current assessment methods pose limitations that render SVP detection unfeasible for glaucoma screening and assessment. This thesis explores the effectiveness of a novel tablet-based ophthalmoscope in detecting and quantifying SVPs in glaucoma. SVP amplitudes were extracted from fundus videos using a custom-written algorithm from 170 participants with a confirmed diagnosis of glaucoma or a glaucoma suspect. SVP’s association with established clinical structural and functional markers for glaucoma were assessed. SVPs were detected and quantified in all participants and were found to be comparable to standard structural markers for distinguishing confirmed glaucoma from glaucoma suspects cases. SVPs were found to differentiate different types of confirmed glaucoma as effectively as measures of intraocular pressure. The tablet-based ophthalmoscope overcomes many disadvantages of current SVP assessment techniques. As the detected SVPs are associated with early clinical markers of glaucoma, they may be used in the early detection of glaucoma and ongoing evaluation and management, potentially limiting glaucoma related vision loss. Further studies are required to determine whether longitudinal changes in SVPs reflect glaucomatous progression.

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http://hdl.handle.net/10453/161722