Dewatering fermentation broth for keto carboxylic acid enrichment by forward osmosis: A techno-economic analysis

Szczygiełda, M; Krajewska, M; Andrzejewski, A; Zheng, L; Nghiem, LD; Oleskowicz-Popiel, P; Szymanowska, D; Prochaska, K

Dewatering fermentation broth for keto carboxylic acid enrichment by forward osmosis: A techno-economic analysis

Szczygiełda, M Krajewska, M Andrzejewski, A Zheng, L Nghiem, LD Oleskowicz-Popiel, P Szymanowska, D Prochaska, K

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Publisher:: ELSEVIER
Publication Type:: Journal Article
Citation:: Journal of Membrane Science, 2023, 679
Issue Date:: 2023-08-05

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Field	Value	Language
dc.contributor.author	Szczygiełda, M
dc.contributor.author	Krajewska, M
dc.contributor.author	Andrzejewski, A
dc.contributor.author	Zheng, L
dc.contributor.author	Nghiem, LD
dc.contributor.author	Oleskowicz-Popiel, P
dc.contributor.author	Szymanowska, D
dc.contributor.author	Prochaska, K
dc.date.accessioned	2024-04-08T08:59:41Z
dc.date.available	2024-04-08T08:59:41Z
dc.date.issued	2023-08-05
dc.identifier.citation	Journal of Membrane Science, 2023, 679
dc.identifier.issn	0376-7388
dc.identifier.issn	1873-3123
dc.identifier.uri	http://hdl.handle.net/10453/177588
dc.description.abstract	This study demonstrated the importance of fermentation broth pretreatment and dewatering by forward osmosis (FO) before keto carboxylic acid recovery. The most effective and profitable pretreatment procedure was a combination of centrifugation, ceramic ultrafiltration of molecular weight cut-off of 15 kDa, and ceramic nanofiltration of molecular weight cut-off of 450 Da. By applying the complex pretreatment and FO as a pre-concentration step of fermentation broth dewatering, the keto acid enrichment of two times was achieved for alpha-ketoglutaric acid and pyruvic acid. Extensive fouling analysis performed in this study confirmed that the proposed pretreatment procedure was sufficient to avoid severe fouling of the FO dewatering process. A techno-economic analysis of the proposed keto acid extraction scheme shown that by using FO for fermentation broth dewatering, the total capital investment was reduced and the payback time was shortened by 0.83 yr.
dc.language	English
dc.publisher	ELSEVIER
dc.relation.ispartof	Journal of Membrane Science
dc.relation.isbasedon	10.1016/j.memsci.2023.121699
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	03 Chemical Sciences, 09 Engineering
dc.subject.classification	Chemical Engineering
dc.subject.classification	34 Chemical sciences
dc.subject.classification	40 Engineering
dc.title	Dewatering fermentation broth for keto carboxylic acid enrichment by forward osmosis: A techno-economic analysis
dc.type	Journal Article
utslib.citation.volume	679
utslib.for	03 Chemical Sciences
utslib.for	09 Engineering
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	University of Technology Sydney/Faculty of Engineering and Information Technology/School of Civil and Environmental Engineering
pubs.organisational-group	University of Technology Sydney/Strength - CTWW - Centre for Technology in Water and Wastewater Treatment
utslib.copyright.status	embargoed	*
utslib.copyright.embargo	2025-08-01T00:00:00+1000Z
dc.date.updated	2024-04-08T08:59:39Z
pubs.publication-status	Published
pubs.volume	679

Abstract:

This study demonstrated the importance of fermentation broth pretreatment and dewatering by forward osmosis (FO) before keto carboxylic acid recovery. The most effective and profitable pretreatment procedure was a combination of centrifugation, ceramic ultrafiltration of molecular weight cut-off of 15 kDa, and ceramic nanofiltration of molecular weight cut-off of 450 Da. By applying the complex pretreatment and FO as a pre-concentration step of fermentation broth dewatering, the keto acid enrichment of two times was achieved for alpha-ketoglutaric acid and pyruvic acid. Extensive fouling analysis performed in this study confirmed that the proposed pretreatment procedure was sufficient to avoid severe fouling of the FO dewatering process. A techno-economic analysis of the proposed keto acid extraction scheme shown that by using FO for fermentation broth dewatering, the total capital investment was reduced and the payback time was shortened by 0.83 yr.

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http://hdl.handle.net/10453/177588