The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.

Peng, J; Cai, Z; Zhao, R; Chen, J; Liu, G; Dong, C; Lim, D; Feng, Z

The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.

Peng, J Cai, Z Zhao, R Chen, J Liu, G Dong, C Lim, D Feng, Z

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Publisher:: OXFORD UNIV PRESS
Publication Type:: Journal Article
Citation:: Toxicol Res (Camb), 2020, 9, (5), pp. 609-621
Issue Date:: 2020-09

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Field	Value	Language
dc.contributor.author	Peng, J
dc.contributor.author	Cai, Z
dc.contributor.author	Zhao, R
dc.contributor.author	Chen, J
dc.contributor.author	Liu, G
dc.contributor.author	Dong, C
dc.contributor.author	Lim, D
dc.contributor.author	Feng, Z
dc.date.accessioned	2024-09-03T23:30:15Z
dc.date.available	2020-08-03
dc.date.available	2024-09-03T23:30:15Z
dc.date.issued	2020-09
dc.identifier.citation	Toxicol Res (Camb), 2020, 9, (5), pp. 609-621
dc.identifier.issn	2045-452X
dc.identifier.issn	2045-4538
dc.identifier.uri	http://hdl.handle.net/10453/180600
dc.description.abstract	This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.
dc.format	Electronic-eCollection
dc.language	eng
dc.publisher	OXFORD UNIV PRESS
dc.relation.ispartof	Toxicol Res (Camb)
dc.relation.isbasedon	10.1093/toxres/tfaa069
dc.rights	info:eu-repo/semantics/closedAccess
dc.subject	0399 Other Chemical Sciences, 1115 Pharmacology and Pharmaceutical Sciences
dc.subject.classification	3214 Pharmacology and pharmaceutical sciences
dc.title	The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs.
dc.type	Journal Article
utslib.citation.volume	9
utslib.location.activity	England
utslib.for	0399 Other Chemical Sciences
utslib.for	1115 Pharmacology and Pharmaceutical Sciences
pubs.organisational-group	University of Technology Sydney
pubs.organisational-group	University of Technology Sydney/Faculty of Health
pubs.organisational-group	University of Technology Sydney/Faculty of Health/IMPACCT
pubs.organisational-group	University of Technology Sydney/All Manual Groups
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Improving Palliative, Aged and Chronic Care through Clinical Research and Translation (IMPACCT)
pubs.organisational-group	University of Technology Sydney/All Manual Groups/UTS Ageing Research Collaborative (UARC)
pubs.organisational-group	University of Technology Sydney/All Manual Groups/Digital, Virtual and AI in Health Collaborative (DVAIHC)
utslib.copyright.status	closed_access	*
dc.date.updated	2024-09-03T23:30:12Z
pubs.issue	5
pubs.publication-status	Published online
pubs.volume	9
utslib.citation.issue	5

Abstract:

This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

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http://hdl.handle.net/10453/180600