Synthesis and impurity profiling of MDMA prepared from commonly available starting materials

Gallagher, R; Shimmon, R; McDonagh, AM

Synthesis and impurity profiling of MDMA prepared from commonly available starting materials

Gallagher, R Shimmon, R

McDonagh, AM

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Publication Type:: Journal Article
Citation:: Forensic Science International, 2012, 223 (1-3), pp. 306 - 313
Issue Date:: 2012-11-30

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Field	Value	Language
dc.contributor.author	Gallagher, R	en_US
dc.contributor.author	Shimmon, R https://orcid.org/0000-0002-8763-991X	en_US
dc.contributor.author	McDonagh, AM https://orcid.org/0000-0002-9502-1175	en_US
dc.date.available	2012-10-04	en_US
dc.date.issued	2012-11-30	en_US
dc.identifier.citation	Forensic Science International, 2012, 223 (1-3), pp. 306 - 313	en_US
dc.identifier.issn	0379-0738	en_US
dc.identifier.uri	http://hdl.handle.net/10453/22786
dc.description.abstract	This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to piperonal by ozonolysis and oxidative cleavage with potassium permanganate and tetrahydrofuran. Vanillin was converted to piperonal by demethylation with pyridine and aluminium chloride followed by methylenation with dichloromethane. The resulting piperonal samples were converted via a commonly encountered route to MDMA. The impurities that indicate a particular route were identified and the feasibility of each method was also assessed. © 2012 Elsevier Ireland Ltd.	en_US
dc.relation.ispartof	Forensic Science International	en_US
dc.relation.isbasedon	10.1016/j.forsciint.2012.10.006	en_US
dc.subject.classification	Legal & Forensic Medicine	en_US
dc.title	Synthesis and impurity profiling of MDMA prepared from commonly available starting materials	en_US
dc.type	Journal Article
utslib.citation.volume	1-3	en_US
utslib.citation.volume	223	en_US
utslib.for	0305 Organic Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
utslib.copyright.status	closed_access
pubs.issue	1-3	en_US
pubs.publication-status	Published	en_US
pubs.volume	223	en_US

Abstract:

This work examines the synthesis of 3,4-methylenedioxy-N-methylamphetamine (MDMA) from common starting materials that may be utilised by clandestine laboratory operators. Piperonal was prepared from two common starting materials, piperine (from pepper) and vanillin (a common flavouring). Piperine was converted to piperonal by ozonolysis and oxidative cleavage with potassium permanganate and tetrahydrofuran. Vanillin was converted to piperonal by demethylation with pyridine and aluminium chloride followed by methylenation with dichloromethane. The resulting piperonal samples were converted via a commonly encountered route to MDMA. The impurities that indicate a particular route were identified and the feasibility of each method was also assessed. © 2012 Elsevier Ireland Ltd.

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http://hdl.handle.net/10453/22786