Identification Of Phosphinate Dipeptide Analog Inhibitors Directed Against The Plasmodium Falciparum M17 Leucine Aminopeptidase As Lead Antimalarial Compounds

Amer Chemical Soc
Publication Type:
Journal Article
Journal Of Medicinal Chemistry, 2007, 50 (24), pp. 6024 - 6031
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Previous studies have pinpointed the M17 leucyl aminopeptidase of Plasmodium falciparum (PfLAP) as a target for the development of new antimalarials. This metallo-exopeptidase functions in the terminal stages of hemoglobin digestion and is inhibited by b
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