The ABC transporter structure and mechanism: perspectives on recent research

Birkhauser Verlag
Publication Type:
Journal Article
Cellular and Molecular Life Sciences, 2004, 61 pp. 682 - 699
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ATP-binding cassetee (ABC) transporters are multidomain integral membrane proteins that utilise the energy of ATP hydrolysis to translocate solutes across cellular membranes in all phyla. ABC transporters form one of the largest of all protein families and are central to many important biomedical phenomena, including resistance of cancers and pathogenic mocribes to drugs. Elucidation of the sturcture and mechanism of ABC transporters is essential to the rational design of agents to control their fuctiom. While a wealth of high-resolution structures of ABC proteins have been produced in recent years, many fundamental questions regarding the protein's mechanism remain unasnwered. I this review, we examine the recent structural data concerning ABC transporters and related proteins in te ligh of other experimental and theoretical data, and discuss these data in relation to current ideas concerning the transporters' molecular mechanism.
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