The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades

Alexander, D; Williams, L; Gatt, J; Dobson-Stone, C; Kuan, S; Todd, E; Schofield, P; Cooper, N

The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades

Alexander, D Williams, L Gatt, J Dobson-Stone, C Kuan, S Todd, E Schofield, P Cooper, N

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Publisher:: Elsevier Science Bv
Publication Type:: Journal Article
Citation:: Alexander, D. et al. 2001 'The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades', Biological Psychology, vol. 75, no. 3, pp. 2243-2251.
Issue Date:: 2007

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Field	Value	Language
dc.contributor.author	Alexander, D	en_US
dc.contributor.author	Williams, L	en_US
dc.contributor.author	Gatt, J	en_US
dc.contributor.author	Dobson-Stone, C	en_US
dc.contributor.author	Kuan, S	en_US
dc.contributor.author	Todd, E	en_US
dc.contributor.author	Schofield, P	en_US
dc.contributor.author	Cooper, N	en_US
dc.date.accessioned	2009-12-21T02:39:06Z
dc.date.available	2009-12-21T02:39:06Z
dc.date.issued	2007	en_US
dc.identifier	2006015382	en_US
dc.identifier.citation	Alexander, D. et al. 2001 'The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades', Biological Psychology, vol. 75, no. 3, pp. 2243-2251.	en_US
dc.identifier.issn	0301-0511	en_US
dc.identifier.other	C1	en_US
dc.identifier.uri	http://hdl.handle.net/10453/5559
dc.description.abstract	Neuroimaging shows brain-functional differences due to apolipoprotein E (APOE) polymorphisms may exist decades before the increased risk period for Alzheimer's disease, but little is known about their effect on cognition and brain function in children and young adults. This study assessed 415 healthy epsilon2 and epsilon4 carriers and matched epsilon3/epsilon3 controls, spanning ages 6-65, on a range of cognitive tests. Subjects were also compared on a new dynamical measure of EEG activity during a visual working memory task using alphabetical stimuli. epsilon4 subjects had better verbal fluency compared to epsilon3, an effect that was strongest in 51-65 year-olds. No epsilon4 deficits in cognition were found. In 6-15 year-olds, there were differences in total spatio-temporal wave activity between epsilon3 and epsilon4 subjects in the theta band, approximately 200ms post-stimulus. Differences in brain function in younger epsilon4 subjects and superior verbal fluency across the entire age range suggest that the APOE epsilon4 allele is an example of antagonistic pleiotropy.	en_US
dc.publisher	Elsevier Science Bv	en_US
dc.relation.ispartof	Biological Psychology	en_US
dc.relation.ispartof	Verified OK	en_US
dc.relation.isbasedon	http://dx.doi.org/10.1016/j.biopsycho.2007.03.001	en_US
dc.subject	Traumatic Brain-injury; E Epsilon-4 Allele; Alzheimers-disease; E Polymorphism; E Genotype; Apoe Genotype; Lipoprotein Receptors; Memory Performance; Young-adults; Older Adults	en_US
dc.subject.classification	Cognitive Sciences	en_US
dc.title	The Contribution Of Apolipoprotein E Alleles On Cognitive Performance And Dynamic Neural Activity Over Six Decades	en_US
dc.type	Journal article
utslib.citation.volume	75	en_US
utslib.citation.number	3	en_US
utslib.location	Amsterdam	en_US
utslib.citation.startpage	229	en_US
utslib.citation.endpage	238	en_US
utslib.identifier.org	FEIT.School of Systems, Management and Leadership	en_US
utslib.for	170200	en_US
utslib.percentage	100	en_US
dc.location.activity	ISI:000248113400002	en_US
utslib.copyright.status	closed_access
pubs.declined	1970-01-01T00:00:00.0+1000

Abstract:

Neuroimaging shows brain-functional differences due to apolipoprotein E (APOE) polymorphisms may exist decades before the increased risk period for Alzheimer's disease, but little is known about their effect on cognition and brain function in children and young adults. This study assessed 415 healthy epsilon2 and epsilon4 carriers and matched epsilon3/epsilon3 controls, spanning ages 6-65, on a range of cognitive tests. Subjects were also compared on a new dynamical measure of EEG activity during a visual working memory task using alphabetical stimuli. epsilon4 subjects had better verbal fluency compared to epsilon3, an effect that was strongest in 51-65 year-olds. No epsilon4 deficits in cognition were found. In 6-15 year-olds, there were differences in total spatio-temporal wave activity between epsilon3 and epsilon4 subjects in the theta band, approximately 200ms post-stimulus. Differences in brain function in younger epsilon4 subjects and superior verbal fluency across the entire age range suggest that the APOE epsilon4 allele is an example of antagonistic pleiotropy.

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http://hdl.handle.net/10453/5559