Discovery of an MIT-like atracotoxin family: spider venom peptides that share sequences homology but not pharmacological properties with AVIT proteins

Publisher:
Elsevier Science
Publication Type:
Journal Article
Citation:
Peptides, 2005, 26 (12), pp. 2412 - 2426
Issue Date:
2005-01
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This project identified a novel family of six 66-68 residue peptides fro the venom of two Australian funnerl-web spiders, Hadronyche sp. 20 and H. infesa: Orchid Beach (Hexathelidae: Atracinae), that appear to undergo N- and/or C-terminal post-translational modifications and conform to an ancestral prtein fold. These peptides all show significant amino acid sequence homology to atracotoxin-Hvf17 (ACTX-Hvf17), a non-toxic peptide isolated from the venom of H. versuta, and a variety of AVIT family proteins including mamba intestinal toxin 1 (MIT1) and its mammalian and piscine orthologs prokineticin 1 (PK1) and prokineticin 2 (PK2).
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