The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki-Heck and Sonagashira coupling reactions

Publisher:
Pergamon
Publication Type:
Journal Article
Citation:
Tetrahedron, 2009, 65 (1), pp. 318 - 327
Issue Date:
2009-01
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2008005057OK.pdf692.89 kB
Adobe PDF
Novel laudanosine dimers in which two laudanosine units are linked at C-2? via a two or three-carbon linker (alkane, alkene or alkyne) have been prepared using palladium-catalysed cross-coupling reactions (MizorokiHeck and Sonagashira reactions). In one example, a second three-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system.
Please use this identifier to cite or link to this item: