An open-loop model for investigating mammalian thermosensitivity
- Publisher:
- Elsevier
- Publication Type:
- Journal Article
- Citation:
- Journal of Thermal Biology, 2004, 29 (7-8), pp. 703 - 707
- Issue Date:
- 2004-01
Closed Access
| Filename | Description | Size | |||
|---|---|---|---|---|---|
 | 2008007299OK.pdf | 250.57 kB |
Copyright Clearance Process
- Recently Added
- In Progress
- Closed Access
This item is closed access and not available.
We have developed, and herein describe, a simple, open-loop model in the rat, in which both skin and hypothalamic temperatures can be modified and clamped. A water-perfused thermode was positioned in the abdomen to drive hypothalamic temperature, and a water-perfused jacket was used to clamp skin temperature. These permitted the independent control of hypothalamic and skin temperatures. The former could be altered between 35 and 41 °C whilst achieving an isothermal skin temperature clamp. Similarly, skin temperature could be modified between 22 and 42 °C whilst hypothalamic temperature was clamped. Maximal hypothalamic heating and cooling rates were: 0.75 and -2.04 °C h-1 100 g-1. We are currently using this animal model to investigate how central thermosensitivity is affected via manipulations of hypothalamic cooling rates.
Please use this identifier to cite or link to this item: