Heightened Alpha(1A)-Adrenergic Receptor Activity Suppresses Ischaemia/Reperfusion-Induced Ins(1,4,5)P-3 Generation In The Mouse Heart: A Comparison With Ischaemic Preconditioning

Publisher:
Portland Press Ltd
Publication Type:
Journal article
Citation:
Amirahmadi F et al. 2008, 'Heightened Alpha(1A)-Adrenergic Receptor Activity Suppresses Ischaemia/Reperfusion-Induced Ins(1,4,5)P-3 Generation In The Mouse Heart: A Comparison With Ischaemic Preconditioning', Portland Press Ltd, vol. 114, no. 2, pp. 157-164.
Issue Date:
2008
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Reperfusion of ischaemic rat or mouse hearts causes NE [noradrenaline ('norepinephrine')] release, stimulation of alpha(1)-ARs (alpha(1)-adrenergic receptors), PLC (phospholipase C) activation, Ins(1,4,5)P-3 generation and the development of arrhythmias.
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