Abnormal Myocardial Contraction In Alpha(1A)- And Alpha(1B)-Adrenoceptor Double-Knockout Mice

Academic Press Ltd Elsevier Science Ltd
Publication Type:
Journal Article
Journal of Molecular Cell Cardiology, 2003, 35 (10), pp. 1207 - 1216
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We used double-knockout mice (ABKO) lacking both predominant myocardial alpha(1)-adrenergic receptor (AR) subtypes (alpha(1A) and alpha(1B)) to determine if alpha(1)-ARs are required for normal myocardial contraction. Langendorff-perfused ABKO hearts had
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