Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates

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Show simple item record Zreiqat, H Roest, R Valenzuela, S Milev, A Ben-Nissan, B 2009-08-20T13:02:29Z 2005
dc.identifier.citation Key Engineering Materials, 2005, 284-286 pp. 541 - 544
dc.identifier.issn 1013-9826
dc.identifier.other C1 en_US
dc.description.abstract Poor cell adhesion to orthopaedic and dental implants results in implant failure. Establishing and maintaining mature bone at the bone/device interface is critical to the long-term success of the prostheses. Considerable effort has been devoted to alter the surface characteristics of these biomaterials in order to improve the initial interlocking of device and skeleton in the non-cemented joint prosthesis. Previously we demonstrated that surface chemistry modification of bioceramics induced osteogenesis. In the present work, we investigate the effect of surface chemistry modification of titanium alloy (Ti-6Al-4V) with alkoxide-derived carbonate hydroxyapatite (CHAp) using sol-gel coating methods on human bone derived cell (HBDC) behaviour. Western blotting demonstrated that sol gel coating of Ti-6Al-4V with CHAp upregulated the expression of key signalling protein Shc isoforms (p46, p52, p66) and phosphorylated Erk1/2. CHAp-modification of Ti-6Al-4V is associated with signal transduction pathways involving the key signalling protein She and ERK1/2 which may lead to enhanced gene expression of extracellular matrix proteins at the skeletal tissue/device interface.
dc.language eng
dc.title Human Bone Derived Cell (HBDC) behaviour of sol-gel derived carbonate hydroxyapatite coatings on titanium alloy substrates
dc.type Journal Article
dc.parent Key Engineering Materials
dc.journal.volume 284-286
dc.journal.number en_US
dc.journal.number 1 en_US
dc.publocation Zurich-Uetikon, Switzerland en_US
dc.publocation Indianapolis, USA
dc.identifier.startpage 541 en_US
dc.identifier.endpage 544 en_US SCI.Faculty of Science en_US
dc.conference Verified OK en_US
dc.conference International Conference on Dependable, Autonomic and Secure Computing
dc.for 0999 Other Engineering
dc.personcode 101355
dc.personcode 760028
dc.personcode 010690
dc.percentage 100 en_US Other Engineering en_US
dc.classification.type FOR-08 en_US
dc.custom 0.278 en_US 2006-10-29
dc.location.activity Indianapolis, USA
dc.description.keywords Hydroxyapatite
dc.description.keywords Intracellular signaling pathways
dc.description.keywords Nanocoatings
dc.description.keywords Osteogenesis
dc.description.keywords Sol-gel
dc.description.keywords Surface modification
dc.description.keywords Titanium alloy
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history Closed (ID: 3)
utslib.collection.history General Collection (ID: 346) [2015-05-15T14:11:39+10:00]

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