Structural properties of liposomes from digital holographic microscopy

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Show simple item record Di Maio, IL Carl, D Langehanenberg, P Valenzuela, SM Battle, AR Al Khazaaly, S Killingsworth, M Kemper, B Von Bally, G Martin, DK 2010-07-13T08:50:51Z 2006
dc.identifier.citation Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2006, 6036
dc.identifier.issn 1605-7422
dc.identifier.other E1 en_US
dc.description.abstract We have constructed liposomes from L-alpha-Phosphatidylcholine (PC) lipids, which are biomimetic lipids similar to those present in the membranes of mammalian cells. We propose an advance in the use of liposomes, such as for drug delivery, to incorporate into the liposomal membranes transport proteins that have been extracted from the lipid membranes of mammalian cells. In this paper, we describe the usage of a novel optical microscope to characterize the nanomechanical properties of these liposomes. We have applied the technique of digital holographic microscopy1, using an instrument recently developed at the University of Münster, Germany. This system enabled us to measure quantitatively the structural changes in liposomes. We have investigated the deformations of these biomimetic lipids comprising these liposomes by applying osmotic stresses, in order to gain insight into the membrane environment prior to incorporation of cloned membrane transport proteins. This control of the nanomechanical properties is important in the stresses transmitted to mechanosensitive ion channels that we have incorporated into the liposomal membranes. These liposomes provide transporting vesicles that respond to mechanical stresses, such as those that occur during implantation.
dc.relation.isbasedon 10.1117/12.638823
dc.title Structural properties of liposomes from digital holographic microscopy
dc.type Conference Proceeding
dc.parent Progress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.journal.volume 6036
dc.journal.number en_US
dc.publocation Bellingham, USA en_US
dc.identifier.startpage en_US
dc.identifier.startpage 1 en_US
dc.identifier.endpage en_US
dc.identifier.endpage 9 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.conference Conference on BioMEMS and Nanotechnology II
dc.for 0304 Medicinal and Biomolecular Chemistry
dc.for 0306 Physical Chemistry (Incl. Structural)
dc.for 1004 Medical Biotechnology
dc.personcode 960727
dc.personcode 995237
dc.personcode 995147
dc.personcode 010690
dc.percentage 50 en_US Medical Biotechnology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom Conference on BioMEMS and Nanotechnology II en_US 20051212 en_US 2005-12-12
dc.location.activity Brisbane, AUSTRALIA en_US
dc.description.keywords Digital holographic microscopy
dc.description.keywords Giant liposomes
dc.description.keywords Multilamellar
dc.description.keywords Unilamellar
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Open Access 2015-04-15 12:23:47.074767+10
pubs.consider-herdc true
utslib.collection.history General (ID: 2)

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