Structural properties of liposomes from digital holographic microscopy

DSpace/Manakin Repository

Search OPUS


Advanced Search

Browse

My Account

Show simple item record

dc.contributor.author Di Maio, IL
dc.contributor.author Carl, D
dc.contributor.author Langehanenberg, P
dc.contributor.author Valenzuela, SM
dc.contributor.author Battle, AR
dc.contributor.author Al Khazaaly, S
dc.contributor.author Killingsworth, M
dc.contributor.author Kemper, B
dc.contributor.author Von Bally, G
dc.contributor.author Martin, DK
dc.date.accessioned 2010-07-13T08:50:51Z
dc.date.issued 2006
dc.identifier.citation Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2006, 6036
dc.identifier.issn 1605-7422
dc.identifier.other E1 en_US
dc.identifier.uri http://hdl.handle.net/10453/12696
dc.description.abstract We have constructed liposomes from L-alpha-Phosphatidylcholine (PC) lipids, which are biomimetic lipids similar to those present in the membranes of mammalian cells. We propose an advance in the use of liposomes, such as for drug delivery, to incorporate into the liposomal membranes transport proteins that have been extracted from the lipid membranes of mammalian cells. In this paper, we describe the usage of a novel optical microscope to characterize the nanomechanical properties of these liposomes. We have applied the technique of digital holographic microscopy1, using an instrument recently developed at the University of Münster, Germany. This system enabled us to measure quantitatively the structural changes in liposomes. We have investigated the deformations of these biomimetic lipids comprising these liposomes by applying osmotic stresses, in order to gain insight into the membrane environment prior to incorporation of cloned membrane transport proteins. This control of the nanomechanical properties is important in the stresses transmitted to mechanosensitive ion channels that we have incorporated into the liposomal membranes. These liposomes provide transporting vesicles that respond to mechanical stresses, such as those that occur during implantation.
dc.relation.isbasedon 10.1117/12.638823
dc.rights Copyright 2006. Society of Photo-Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic electronic or print reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. en_US
dc.title Structural properties of liposomes from digital holographic microscopy
dc.type Conference Proceeding
dc.parent Progress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.journal.volume 6036
dc.journal.number en_US
dc.publocation Bellingham, USA en_US
dc.publocation Bellingham, USA
dc.identifier.startpage en_US
dc.identifier.startpage 1 en_US
dc.identifier.endpage en_US
dc.identifier.endpage 9 en_US
dc.cauo.name SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.conference Conference on BioMEMS and Nanotechnology II
dc.for 0304 Medicinal and Biomolecular Chemistry
dc.for 0306 Physical Chemistry (Incl. Structural)
dc.for 1004 Medical Biotechnology
dc.personcode 960727
dc.personcode 995237
dc.personcode 995147
dc.personcode 010690
dc.percentage 50 en_US
dc.classification.name Medical Biotechnology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom Conference on BioMEMS and Nanotechnology II en_US
dc.date.activity 20051212 en_US
dc.date.activity 2005-12-12
dc.location.activity Brisbane, AUSTRALIA en_US
dc.location.activity Brisbane, AUSTRALIA
dc.description.keywords giant liposomes, unilamellar, multilamellar, digital holographic microscopy en_US
dc.description.keywords giant liposomes, unilamellar, multilamellar, digital holographic microscopy
dc.description.keywords Digital holographic microscopy
dc.description.keywords Giant liposomes
dc.description.keywords Multilamellar
dc.description.keywords Unilamellar
dc.description.keywords Digital holographic microscopy
dc.description.keywords Digital holographic microscopy
dc.description.keywords Giant liposomes
dc.description.keywords Giant liposomes
dc.description.keywords Multilamellar
dc.description.keywords Multilamellar
dc.description.keywords Unilamellar
dc.description.keywords Unilamellar
dc.description.keywords Digital holographic microscopy
dc.description.keywords Giant liposomes
dc.description.keywords Multilamellar
dc.description.keywords Unilamellar
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Open Access
utslib.copyright.date 2015-04-15 12:23:47.074767+10


Files in this item

This item appears in the following Collection(s)

Show simple item record