Spider Venom Peptides

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dc.contributor.author Nicholson, GM
dc.date.accessioned 2010-07-15T07:26:00Z
dc.date.issued 2006
dc.identifier.citation Handbook of Biologically Active Peptides, 2006, pp. 369 - 379
dc.identifier.isbn 9780123694423
dc.identifier.other B1 en_US
dc.identifier.uri http://hdl.handle.net/10453/12750
dc.description.abstract Spider venom peptides and protein toxins are recognized as highly potent and specific molecular tools that modulate neurotransmission via interaction with a variety of ion channels, receptors, and transporters in vertebrates and invertebrates. Spiders have, during their evolution, developed a complex preoptimized combinatorial peptide library of enzymes, neurotoxins, and antimicrobial and cytolytic peptides in their venom glands. The role of spider venom is to paralyze and/or kill prey or predators as rapidly as possible. Therefore, their venoms are particularly rich in neurotoxins that rapidly modify ion conductance (ion channel toxins) and to a lesser extent affect neurotransmitter exocytosis (presynaptic toxins) and interfere with the binding of neurotransmitters (postsynaptic toxins). Many of these peptides are selectively insecticidal or modulate the activity of various targets in vertebrates, including humans. In particular, insect-selective atracotoxins are now being investigated for their possible use as bioinsecticidal agents for the control of phytophagous pests or insect vectors of new or reemerging disease. © 2006 Elsevier Inc. All rights reserved.
dc.publisher Elsevier Inc.
dc.relation.isbasedon 10.1016/B978-012369442-3/50057-X
dc.title Spider Venom Peptides
dc.type Chapter
dc.parent Handbook of Biologically Active Peptides
dc.journal.number en_US
dc.publocation San Diego, USA en_US
dc.identifier.startpage 369 en_US
dc.identifier.endpage 379 en_US
dc.cauo.name FEIT. A/DRsch Ctre for Health Technologies en_US
dc.conference Verified OK en_US
dc.for 060108 Protein Trafficking
dc.for 111506 Toxicology (Incl. Clinical Toxicology)
dc.personcode 870145
dc.percentage 50 en_US
dc.classification.name Toxicology (incl. Clinical Toxicology) en_US
dc.classification.type FOR-08 en_US
dc.edition 1 en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords peptides, toxins, spider venom en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
utslib.copyright.status Closed Access
utslib.copyright.date 2015-04-15 12:17:09.805752+10
utslib.collection.history Closed (ID: 3)

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