Sequences Of The Genes And Polypeptide Precursors For 2 Bovine Protease Inhibitors

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Show simple item record Creighton, TE Charles, IG 2011-02-07T06:21:05Z 1987-01
dc.identifier.citation Journal of Molecular Biology, 1987, 194 (1), pp. 11 - 22
dc.identifier.issn 0022-2836
dc.identifier.other C1UNSUBMIT en_US
dc.description.abstract The genes for bovine pancreatic trypsin inhibitor and a homologous protease inhibitor have been characterized using messenger RNA, clones of complementary DNA copies and genomic fragments. Both genes consist of three exons and two introns and are virtually identical in sequence, suggesting that recently they either arose by gene duplication or were subject to gene conversion. However, they differ markedly in their promoter regions and in a segment within the first intron. Perhaps as a consequence, the two genes can be expressed using different transcription start sites, and the two proteins are found in different bovine tissues. Each middle exon encodes primarily the mature protein, while the other two exons define amino- and carboxyl-terminal extensions of 33 or 35 and 7 amino acid residues, respectively. The amino-terminal extensions contain a signal peptide-like sequence, suggesting that the proteins are destined for cellular compartments. The remaining extensions at both ends may be involved in targetting of the proteins, and there are some similarities to other proteins destined for cellular compartments.
dc.format Yes
dc.publisher Academic Press Ltd
dc.relation.isbasedon 10.1016/0022-2836(87)90711-X
dc.title Sequences Of The Genes And Polypeptide Precursors For 2 Bovine Protease Inhibitors
dc.type Journal Article
dc.parent Journal of Molecular Biology
dc.journal.volume 1
dc.journal.volume 194
dc.journal.number 1 en_US
dc.publocation London en_US
dc.identifier.startpage 11 en_US
dc.identifier.endpage 22 en_US SCI.Medical and Molecular Biosciences en_US
dc.conference Verified OK en_US
dc.for 0601 Biochemistry and Cell Biology
dc.personcode 109028
dc.percentage 100 en_US Biochemistry and Cell Biology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity ISI:A1987G456800002 en_US
dc.location.activity ISI:A1987G456800002
dc.description.keywords BPTI, bovine pancreatic trypsin inhibitor (also known as trypsin-kallikrein inhibitor
dc.description.keywords aprotinin, Trasylol@)
dc.description.keywords SI, spleen inhibitor homologous with BPTI
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc false
utslib.collection.history Closed (ID: 3)

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