Peroxiredoxin: a central player in immune modulation.

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dc.contributor.author Robinson, MW
dc.contributor.author Hutchinson, AT
dc.contributor.author Dalton, JP
dc.contributor.author Donnelly, S
dc.date.accessioned 2011-02-07T06:21:08Z
dc.date.issued 2010-05
dc.identifier.citation Parasite immunology, 2010, 32 (5), pp. 305 - 313
dc.identifier.issn 0141-9838
dc.identifier.other C1 en_US
dc.identifier.uri http://hdl.handle.net/10453/13376
dc.description.abstract Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts.
dc.format Print
dc.language eng
dc.relation.isbasedon 10.1111/j.1365-3024.2010.01201.x
dc.subject Animals, Helminth Proteins, Peroxiredoxins, Animals, Helminth Proteins, Peroxiredoxins, helminth, immunomodulation, macrophage, peroxiredoxin, Mycology & Parasitology
dc.subject Animals; Helminth Proteins; Peroxiredoxins; Animals; Helminth Proteins; Peroxiredoxins; helminth; immunomodulation; macrophage; peroxiredoxin; Mycology & Parasitology
dc.title Peroxiredoxin: a central player in immune modulation.
dc.type Journal Article
dc.parent Parasite immunology
dc.journal.volume 5
dc.journal.volume 32
dc.journal.number 5 en_US
dc.publocation Singapore en_US
dc.identifier.startpage 305 en_US
dc.identifier.endpage 313 en_US
dc.cauo.name SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 0707 Veterinary Sciences
dc.personcode 100777 en_US
dc.personcode 100527 en_US
dc.personcode 995261 en_US
dc.personcode 030896 en_US
dc.percentage 100 en_US
dc.classification.name Veterinary Sciences en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US
dc.date.activity en_US
dc.location.activity en_US
dc.description.keywords helminth;immunomodulation;macrophage;peroxiredoxin en_US
dc.description.keywords Animals
dc.description.keywords Helminth Proteins
dc.description.keywords Peroxiredoxins
dc.staffid 030896 en_US
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Faculty of Science/School of Medical and Molecular Sciences
pubs.organisational-group /University of Technology Sydney/Strength - Health Technologies
pubs.organisational-group /University of Technology Sydney/Strength - i3


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