RSF1010-like plasmids in Australian Salmonella enterica Serovar Typhimurium and origin of their sul2-strA-strB antibiotic resistance gene cluster

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Show simple item record Yau, S Liu, X Djordjevic, SP Hall, RM 2011-02-07T06:21:39Z 2010-01
dc.identifier.citation Microbial Drug Resistance, 2010, 16 (4), pp. 249 - 252
dc.identifier.issn 1076-6294
dc.identifier.other C1 en_US
dc.description.abstract Salmonella enterica serovar Typhimurium phage type 9 isolates resis1ant tQ streptomycin and sulfonamide have been recovered from both bovine and human sources in Australia. This study aimed to identify the resistance genes and their location. Polymerase chain reaction was used to screen for resistance genes and sul2 (sulphonamide resistance) and strA and strB (streptomycin resistance) were detected. A small streptomycin and sulfonamide resistance plasmid carrying the three resistance genes was recovered from these isolates by transformation and was shown to be essentially identical to the small IncQ plasmid RSFIOIO. The sequences of one plasmid, pSRC15, and RSFIOIO differed at only a few positions that may be errors in the older sequence, RSFIOIO has been recovered from many species and in many countries since its first isolation in the early 1970s. We conclude that this plasmid has persisted unchanged in the environrn"ent for over 30 years. The antibiotic resistance gene cluster containing strA, strB, and sul2 genes has clearly arisen from other known entities by a combination of transposition and homologous recombination using a short segment of homology. This resistance gene cluster is now widely distributed in plasmids and genomic islands in a number of contexts.
dc.publisher Mary Ann Liebert, Inc
dc.relation.isbasedon 10.1089/mdr.2010.0033
dc.title RSF1010-like plasmids in Australian Salmonella enterica Serovar Typhimurium and origin of their sul2-strA-strB antibiotic resistance gene cluster
dc.type Journal Article
dc.parent Microbial Drug Resistance
dc.journal.volume 4
dc.journal.volume 16
dc.journal.number 4 en_US
dc.publocation United States en_US
dc.identifier.startpage 249 en_US
dc.identifier.endpage 252 en_US SCI.Institute for Biotechnology of Infectious Diseases en_US
dc.conference Verified OK en_US
dc.for 0605 Microbiology
dc.personcode 107126
dc.percentage 100 en_US Microbiology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.custom en_US en_US
dc.location.activity en_US
dc.description.keywords NA
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - i3
utslib.copyright.status Closed Access 2015-04-15 12:17:09.805752+10
pubs.consider-herdc true
utslib.collection.history Uncategorised (ID: 363)
utslib.collection.history Closed (ID: 3)

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