Acute, multiple-dose dermal and genetic toxicity of Nu-3: A novel antimicrobial agent

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Show simple item record Sun, L-Q Sun, J Hu, Y Cao, S Zhang, G Wang, M 2011-02-07T06:23:54Z 2010
dc.identifier.citation Journal of Biomedicine and Biotechnology, 2010, 2010
dc.identifier.issn 1110-7243
dc.identifier.other C1 en_US
dc.description.abstract Nu-3 [butyl-phosphate- 5 ′ -thymidine- 3 ′ -phosphate-butyl] is a modified nucleotide that has been shown to have antimicrobial activity against a range of bacteria including Pseudomonas aeruginosa. However, data on the toxicological profile of Nu-3 are still lacking. In the present study, the toxicity of Nu-3 was evaluated by the following studies: acute oral toxicity, dermal and mucous membrane irritation, multiple-dose toxicity and genotoxicity in vivo and vitro. The acute oral toxicity test in mice showed that Nu-3 had an LD 50 of 2001mg/kg body weight. The irritation tests on rats revealed that Nu-3 was not irritant, with an irritation scoring of 0. The multiple-dose toxicity study in rats showed that Nu-3 did not cause significant changes in histology, selected serum chemistry, and hematological parameters compared to the controls. Rats administrated with multiple-doses of Nu-3 showed no visible toxic symptoms. Both in vitro and in vivo, Nu-3 exhibited no notable genetic toxicity. Overall, the data suggest that Nu-3 is hypotoxic or nontoxic antimicrobial compound that warrants being further developed for treating Pseudomonas aeruginosa infection. © 2010 Juan Sun et al.
dc.language eng
dc.relation.isbasedon 10.1155/2010/362524
dc.subject Animals, Mice, Inbred BALB C, Cricetulus, Mice, Rats, Spleen, Mucous Membrane, T-Lymphocytes, Eye, Liver, Kidney, CHO Cells, Thymine Nucleotides, Thymidine Monophosphate, Analysis of Variance, Micronucleus Tests, Histocytochemistry, Skin Irritancy Tests, Lethal Dose 50, Cell Proliferation, Anti-Infective Agents, Mutagenicity Tests, Rats, Sprague-Dawley, Toxicity Tests, Acute, Skin, Female, Cricetinae, Male, Analysis of Variance, Animals, Anti-Infective Agents, CHO Cells, Cell Proliferation, Cricetinae, Cricetulus, Eye, Female, Histocytochemistry, Kidney, Lethal Dose 50, Liver, Male, Mice, Mice, Inbred BALB C, Micronucleus Tests, Mucous Membrane, Mutagenicity Tests, Rats, Rats, Sprague-Dawley, Skin, Skin Irritancy Tests, Spleen, T-Lymphocytes, Thymidine Monophosphate, Thymine Nucleotides, Toxicity Tests, Acute, Cho-Hgprt System, Resistant Pseudomonas-Aeruginosa, Intensive-Care Units, Beta-Lactamase, Burn Unit, Outbreak, Assay, Biotechnology
dc.subject Animals; Mice, Inbred BALB C; Cricetulus; Mice; Rats; Spleen; Mucous Membrane; T-Lymphocytes; Eye; Liver; Kidney; CHO Cells; Thymine Nucleotides; Thymidine Monophosphate; Analysis of Variance; Micronucleus Tests; Histocytochemistry; Skin Irritancy Tests; Lethal Dose 50; Cell Proliferation; Anti-Infective Agents; Mutagenicity Tests; Rats, Sprague-Dawley; Toxicity Tests, Acute; Skin; Female; Cricetinae; Male; Analysis of Variance; Animals; Anti-Infective Agents; CHO Cells; Cell Proliferation; Cricetinae; Cricetulus; Eye; Female; Histocytochemistry; Kidney; Lethal Dose 50; Liver; Male; Mice; Mice, Inbred BALB C; Micronucleus Tests; Mucous Membrane; Mutagenicity Tests; Rats; Rats, Sprague-Dawley; Skin; Skin Irritancy Tests; Spleen; T-Lymphocytes; Thymidine Monophosphate; Thymine Nucleotides; Toxicity Tests, Acute; Cho-Hgprt System; Resistant Pseudomonas-Aeruginosa; Intensive-Care Units; Beta-Lactamase; Burn Unit; Outbreak; Assay; Biotechnology
dc.title Acute, multiple-dose dermal and genetic toxicity of Nu-3: A novel antimicrobial agent
dc.type Journal Article
dc.parent Journal of Biomedicine and Biotechnology
dc.journal.volume 2010
dc.publocation New York en_US
dc.publocation Denmark
dc.identifier.startpage 1 en_US
dc.identifier.endpage 8 en_US FEIT.School of Systems, Management and Leadership en_US
dc.conference Verified OK en_US
dc.for 1004 Medical Biotechnology
dc.personcode 0000050076 en_US
dc.personcode 0000049298 en_US
dc.personcode 0000064475 en_US
dc.personcode 020014 en_US
dc.personcode 104335 en_US
dc.personcode 0000021071 en_US
dc.percentage 100 en_US Medical Biotechnology en_US
dc.classification.type FOR-08 en_US
dc.edition en_US
dc.edition 1st
dc.custom en_US en_US
dc.location.activity ISI:000281300400001 en_US
dc.location.activity ISI:000281300400001
dc.description.keywords Cho-Hgprt System; Resistant Pseudomonas-Aeruginosa; Intensive-Care Units; Beta-Lactamase; Burn Unit; Outbreak; Assay en_US
dc.description.keywords Three Time-Zone (3TZ), Virtual Student Exchange (VSX), Collaborative Environment, Group Project Management, On-Demand Virtual Labs (ODVL)
dc.description.keywords Cho-Hgprt System
dc.description.keywords Resistant Pseudomonas-Aeruginosa
dc.description.keywords Intensive-Care Units
dc.description.keywords Beta-Lactamase
dc.description.keywords Burn Unit
dc.description.keywords Outbreak
dc.description.keywords Assay
pubs.embargo.period Not known
pubs.organisational-group /University of Technology Sydney
pubs.organisational-group /University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group /University of Technology Sydney/Faculty of Science
pubs.organisational-group /University of Technology Sydney/Strength - Quantum Computation and Intelligent Systems

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